Patents by Inventor Angela R. Brooks-Wilson

Angela R. Brooks-Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotide encoding an ATP binding cassette transporter 1 (ABC1) polypeptide
    Patent number: 8067219
    Abstract: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: November 29, 2011
    Assignees: Xenon Pharmaceuticals Inc., University of British Columbia
    Inventors: Michael R. Hayden, Angela R. Brooks-Wilson, Simon N. Pimstone
  • Methods and reagents for modulating cholesterol levels
    Publication number: 20110065147
    Abstract: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
    Type: Application
    Filed: September 14, 2010
    Publication date: March 17, 2011
    Inventors: Michael R. Hayden, Angela R. Brooks-Wilson, Simon N. Pimstone
  • Methods and reagents for modulating cholesterol levels
    Patent number: 7785886
    Abstract: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: August 31, 2010
    Assignees: Xenon Pharmaceuticals, Inc., Univ. of British Columbia
    Inventors: Michael R. Hayden, Angela R. Brooks-Wilson, Simon N. Pimstone
  • Cholesterol transport gene
    Patent number: 7166584
    Abstract: Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: January 23, 2007
    Assignees: Wisconsin Alumni Research Foundation, Xenon Genetics, Inc.
    Inventors: Alan D. Attie, Mark Cook, Mark P. Gray-Keller, Michael R. Hayden, Simon Pimstone, Angela R. Brooks-Wilson
  • Compositions and methods for modulating HDL cholesterol and triglyceride levels
    Publication number: 20040229275
    Abstract: The invention features methods for treating patients having low HDL, a higher than normal triglyceride level, or a cardiovascular disease by administering compounds that modulate ABC1 expression or activity.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 18, 2004
    Inventors: Michael R. Hayden, Angela R. Brooks-Wilson, Simon N. Pimstone, Susanne M. Clee
  • Methods and reagents for modulating cholesterol levels
    Publication number: 20040185508
    Abstract: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
    Type: Application
    Filed: April 28, 2004
    Publication date: September 23, 2004
    Inventors: Michael R. Hayden, Angela R. Brooks-Wilson, Simon N. Pimstone
  • Compositions and methods for modulating HDL cholesterol and triglyceride levels
    Publication number: 20040137423
    Abstract: The invention provides methods for identifying agents that modulate HDL-levels in animals by evaluating the ability of LXR-modulating agents to increase ABCA1-gene expression in a cell as well as using such agents to treat conditions involving lower than normal HDL-levels, higher than normal triglyceride levels and the like.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Inventors: Michael R. Hayden, Angela R. Brooks-Wilson, Simon N. Pimstone, Susanne M. Clee
  • Methods and reagents for modulating cholesterol levels
    Publication number: 20040058869
    Abstract: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
    Type: Application
    Filed: July 10, 2003
    Publication date: March 25, 2004
    Inventors: Michael R. Hayden, Angela R. Brooks Wilson, Simon N. Pimstone
  • Asthma related genes
    Patent number: 6087485
    Abstract: A genetic locus associated with asthma is identified. The genes within the locus, ASTH1I and ASTH1J, and the regulatory sequences of the locus are characterized. The genes are used to produce the encoded proteins; in screening for compositions that modulate the expression or function of ASTH1 proteins; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to asthma.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: July 11, 2000
    Assignee: AxyS Pharmaceuticals, Inc.
    Inventors: Angela R. Brooks-Wilson, Alan Buckler, Lon Cardon, Alisoun H. Carey, Margaret Galvin, Andrew Miller, Michael North