Abstract: A pedestal system includes a cabinet having a bottom wall, a top wall, a pair of sidewalls, and a rear wall that cooperate to define a forwardly-opening aperture that slidably receives a plurality of drawer assemblies therein. The pedestal system further includes interchangeable face plates for covering the drawer assemblies, an attachment system for attaching a drawer lock/interlock assembly that locks the drawer assemblies in a closed position and prevents multiple drawer assemblies from being simultaneously opened, and a drawer divider for segmenting an interior space of each drawer assembly. The drawer lock/interlock system includes a cam assembly that allows a constant force to be applied to each drawer assembly while opening each drawer and activating the lock/interlock assembly. The pedestal system further includes an attachment system for attaching the pedestal system to a free-standing partition system.

Abstract: Provided is ascomycin that has a low level of an FK523 impurity, and pimecrolimus that has a low level of a 32-deoxy-32-epichloro-FK523 impurity, methods of preparing them, and the use of such pimecrolimus for preparing a pharmaceutical composition.

Abstract: A pedestal system includes a cabinet having a bottom wall, a top wall, a pair of sidewalls, and a rear wall that cooperate to define a forwardly-opening aperture that slidably receives a plurality of drawer assemblies therein. The pedestal system further includes interchangeable face plates for covering the drawer assemblies, an attachment system for attaching a drawer lock/interlock assembly that locks the drawer assemblies in a closed position and prevents multiple drawer assemblies from being simultaneously opened, and a drawer divider for segmenting an interior space of each drawer assembly. The drawer lock/interlock system includes a cam assembly that allows a constant force to be applied to each drawer assembly while opening each drawer and activating the lock/interlock assembly. The pedestal system further includes an attachment system for attaching the pedestal system to a free-standing partition system.

Abstract: The invention provides a process for the chromatographic purification of Tacrolimus, using a silver modified sorbent, selected from the group consisting of silver modified aluminum oxide, zirconium oxide, styrene divinylbenzene copolymer, adsorption resin, cation exchange resin, anion exchange resin, reverse phase silica gel, and cyano silica-gel, and separating the Tacrolimus chromatographically with the silver modified sorbent as a stationary phase.

Abstract: The invention provides pure tacrolimus and a method for purifying tacrolimus in which a loading charge of tacrolimus is placed in juxtaposition with a bed of wet sorption resin, the loading charge and bed are eluted with an eluent comprising THF, acetonitrile, or a combination thereof, water, and, optionally, at least one additional organic solvent, the heart cut of the eluent is collected, and tacrolimus is collected, the tacrolimus is further crystallized and recrystallized until obtaining a reduced level of impurities.

Abstract: A pedestal system includes a cabinet having a bottom wall, a top wall, a pair of sidewalls, and a rear wall that cooperate to define a forwardly-opening aperture that slidably receives a plurality of drawer assemblies therein. The pedestal system further includes interchangeable face plates for covering the drawer assemblies, an attachment system for attaching a drawer lock/interlock assembly that locks the drawer assemblies in a closed position and prevents multiple drawer assemblies from being simultaneously opened, and a drawer divider for segmenting an interior space of each drawer assembly. The drawer lock/interlock system includes a cam assembly that allows a constant force to be applied to each drawer assembly while opening each drawer and activating the lock/interlock assembly. The pedestal system further includes an attachment system for attaching the pedestal system to a free-standing partition system.