Patents by Inventor Angeles Estelles

Angeles Estelles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies targeting killer immunoglobulin-like receptor (KIR) family signaling
    Patent number: 11725055
    Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: August 15, 2023
    Inventors: Angeles Estelles, Mikhail Gishizky, Stefan Ryser, Lawrence M. Kauvar
  • ENGINEERED CD25 POLYPEPTIDES AND USES THEREOF
    Publication number: 20230016112
    Abstract: Provided herein engineered polypeptides that comprise a combination of spatially-associated topological constraints, wherein at least one constraint is derived from a CD25 reference target, and methods of selecting said engineered polypeptides. Further provided are methods of using the engineered polypeptides, including as positive and/or negative selection molecules in methods of screening a library of binding molecules such as antibodies. Further provided herein are CD25 antibodies selected using these engineered polypeptides.
    Type: Application
    Filed: May 13, 2021
    Publication date: January 19, 2023
    Inventors: Matthew P. GREVING, Phung Tu GIP, Mohan SRINIVASAN, Andrew MORIN, Kevin Eduard HAUSER, Jordan R. WILLIS, Cody A. MOORE, Christian BARRETT, Alex T. TAGUCHI, Angeles ESTELLES
  • BINDING MOIETIES FOR BIOFILM REMEDIATION
    Publication number: 20220259294
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Application
    Filed: January 5, 2022
    Publication date: August 18, 2022
    Applicant: TRELLIS BIOSCIENCE, LLC
    Inventors: Lawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Reyna J. SIMON, Lauren Opremcak BAKALETZ, Steven David GOODMAN
  • ANTIBODIES USEFUL IN PASSIVE INFLUENZA IMMUNIZATION, AND COMPOSITIONS, COMBINATIONS AND METHODS FOR USE THEREOF
    Publication number: 20220111049
    Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 14, 2022
    Inventors: Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
  • Binding moieties for biofilm remediation
    Patent number: 11248040
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: February 15, 2022
    Assignee: TRELLIS BIOSCIENCE, LLC
    Inventors: Lawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
  • Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
    Patent number: 11246928
    Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: February 15, 2022
    Assignees: CONTRAFECT CORPORATION, TRELLIS BIOSCIENCE, LLC
    Inventors: Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
  • NATIVE HUMAN ANTIBODIES FOR IMMUNE CHECKPOINT MODULATION TARGETS TIM-3 AND B7-H3
    Publication number: 20210277116
    Abstract: Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 9, 2021
    Applicant: TRELLIS BIOSCIENCE, LLC
    Inventors: Angeles ESTELLES, Mikhail GISHIZKY, Stefan RYSER, Lawrence M. KAUVAR
  • Native human antibodies for immune checkpoint modulation targets TIM-3 and B7-H3
    Patent number: 11046764
    Abstract: Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: June 29, 2021
    Assignee: Trellis Bioscience, LLC
    Inventors: Angeles Estelles, Mikhail Gishizky, Stefan Ryser, Lawrence M. Kauvar
  • MONOCLONAL ANTIBODIES TARGETING KILLER IMMUNOGLOBULIN-LIKE RECEPTOR (KIR) FAMILY SIGNALING
    Publication number: 20210054075
    Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
    Type: Application
    Filed: November 6, 2020
    Publication date: February 25, 2021
    Applicant: Trellis Bioscience, LLC
    Inventors: Angeles ESTELLES, Mikhail GISHIZKY, Stefan RYSER, Lawrence M. KAUVAR
  • Monoclonal antibodies targeting killer immunoglobulin-like receptor (KIR) family signaling
    Patent number: 10858431
    Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 8, 2020
    Assignee: Trellis Bioscience, LLC
    Inventors: Angeles Estelles, Mikhail Gishizky, Stefan Ryser, Lawrence M. Kauvar
  • BINDING MOIETIES FOR BIOFILM REMEDIATION
    Publication number: 20200190170
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Application
    Filed: January 17, 2020
    Publication date: June 18, 2020
    Applicant: TRELLIS BIOSCIENCE, LLC
    Inventors: Lawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Reyna J. SIMON, Lauren Opremcak BAKALETZ, Steven David GOODMAN
  • Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
    Patent number: 10639370
    Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: May 5, 2020
    Assignees: CONTRAFECT CORPORATION, TRELLIS BIOSCIENCE, LLC
    Inventors: Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
  • Binding moieties for biofilm remediation
    Patent number: 10570193
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: February 25, 2020
    Assignee: Trellis Bioscience, LLC
    Inventors: Lawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
  • ANTIBODIES USEFUL IN PASSIVE INFLUENZA IMMUNIZATION, AND COMPOSITIONS, COMBINATIONS AND METHODS FOR USE THEREOF
    Publication number: 20200054749
    Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
    Type: Application
    Filed: November 5, 2019
    Publication date: February 20, 2020
    Inventors: Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
  • Binding moieties for biofilm remediation
    Patent number: 10233234
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: March 19, 2019
    Assignee: Trellis Bioscience, LLC
    Inventors: Lawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
  • BINDING MOIETIES FOR BIOFILM REMEDIATION
    Publication number: 20190055304
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Application
    Filed: November 5, 2018
    Publication date: February 21, 2019
    Applicant: Trellis Bioscience, LLC
    Inventors: Lawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Reyna J. SIMON, Lauren Opremcak BAKALETZ, Steven David GOODMAN
  • NATIVE HUMAN ANTIBODIES FOR IMMUNE CHECKPOINT MODULATION TARGETS TIM-3 AND B7-H3
    Publication number: 20180186880
    Abstract: Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 5, 2018
    Applicant: Trellis Bioscience, LLC
    Inventors: Angeles ESTELLES, Mikhail GISHIZKY, Stefan RYSER, Lawrence M. KAUVAR
  • MONOCLONAL ANTIBODIES TARGETING KILLER IMMUNOGLOBULIN-LIKE RECEPTOR (KIR) FAMILY SIGNALING
    Publication number: 20180002420
    Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
    Type: Application
    Filed: June 9, 2017
    Publication date: January 4, 2018
    Applicant: Trellis Bioscience, LLC
    Inventors: Angeles ESTELLES, Mikhail GISHIZKY, Stefan RYSER, Lawrence M. KAUVAR
  • ANTIBODIES USEFUL IN PASSIVE INFLUENZA IMMUNIZATION, AND COMPOSITIONS, COMBINATIONS AND METHODS FOR USE THEREOF
    Publication number: 20170189529
    Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
    Type: Application
    Filed: February 4, 2015
    Publication date: July 6, 2017
    Inventors: Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
  • BINDING MOIETIES FOR BIOFILM REMEDIATION
    Publication number: 20160237145
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 18, 2016
    Applicant: Trellis Bioscience, LLC
    Inventors: Lawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Reyna J. SIMON