Patents by Inventor Angeles MARTIN-REQUERO

Angeles MARTIN-REQUERO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CDC-7-inhibitor compounds and use thereof for the treatment of neurological conditions
    Patent number: 11446304
    Abstract: The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 20, 2022
    Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)
    Inventors: Ana Martinez Gil, Daniel I. Perez, Carmen Gil Ayuso-Gontán, Angeles Martin-Requero, Elisa Rojas Prats, Loreto Martinez-Gonzalez, Concepción Perez
  • CDC7-Inhibiting Purine Derivatives and their use for the Treatment of Neurological Conditions
    Publication number: 20210346388
    Abstract: The present invention relates to the use of a series of purine derivatives having the following general formula: (I) and which are capable of inhibiting CDC7 kinase activity and, therefore, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, which involve hyperphosphorylation of TDP-43 and the subsequent formation of clusters, induced by CDC7.
    Type: Application
    Filed: September 23, 2019
    Publication date: November 11, 2021
    Inventors: Ana MARTINEZ GIL, Carmen GIL AYUSO-GONTAN, Angeles MARTIN REQUERO, Elisa ROJAS PRATS, Loreto MARTINEZ-GONZALEZ
  • CDC-7-INHIBITOR COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS
    Publication number: 20200093828
    Abstract: The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.
    Type: Application
    Filed: March 21, 2018
    Publication date: March 26, 2020
    Inventors: Ana MARTINEZ GIL, Daniel PEREZ, Carmen GIL AYUSO-GONTÁN, Angeles MARTIN-REQUERO, Elisa ROJAS PRATS, Loreto MARTINEZ-GONZALEZ, Concepción PEREZ