Patents by Inventor Angelica B. Kielbus

Angelica B. Kielbus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC PROCESSES FOR THE PREPARATION OF (±)-2-(DIFLUOROMETHYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID AND (±)-2-(VINYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20210087592
    Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: May 11, 2020
    Publication date: March 25, 2021
    Inventors: Michael J. Abrahamson, Sanjay R. Chemburkar, Angelica B. Kielbus, Russell D. Cink
  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-NON-8-ENOIC ACID
    Publication number: 20200325506
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Application
    Filed: November 4, 2019
    Publication date: October 15, 2020
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • Enzymatic processes for the preparation of (±)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and (±)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid
    Patent number: 10689675
    Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 23, 2020
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Sanjay R. Chemburkar, Angelica B. Kielbus, Russell D. Cink
  • ENZYMATIC PROCESS FOR THE PREPARATION OF (1S,2R)-2-(DIFLUOROMETHYL)-1-(PROPOXYCARBONYL)CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20200024621
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: June 7, 2019
    Publication date: January 23, 2020
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Stefan Mix, Gareth J. Brown
  • Process for the preparation of (S)-2-amino-non-8-enoic acid
    Patent number: 10465216
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: November 5, 2019
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid
    Patent number: 10316338
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Abb Vie Inc.
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Gareth J. Brown, Stefan Mix
  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-NON-8-ENOIC ACID
    Publication number: 20190048372
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Application
    Filed: August 27, 2018
    Publication date: February 14, 2019
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • ENZYMATIC PROCESSES FOR THE PREPARATION OF (±)-2-(DIFLUOROMETHYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID AND (±)-2-(VINYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20180258451
    Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: February 1, 2018
    Publication date: September 13, 2018
    Inventors: Michael J. Abrahamson, Sanjay R. Chemburkar, Angelica B. Kielbus, Russell D. Cink
  • Process for the preparation of (S)-2-amino-non-8-enoic acid
    Patent number: 10059969
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 28, 2018
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar