Patents by Inventor Angelo Amabile

Angelo Amabile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PERMANENT EPIGENETIC GENE SILENCING
    Publication number: 20250236870
    Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).
    Type: Application
    Filed: October 18, 2024
    Publication date: July 24, 2025
    Applicants: Ospedale San Raffaele S.R.L., Fondazione Telethon
    Inventors: Luigi Naldini, Angelo Leone Lombardo, Angelo Amabile, Alessandro Migliara
  • Permanent epigenetic gene silencing
    Patent number: 12152240
    Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: November 26, 2024
    Assignees: Ospedale San Raffaele S.R.L., Fondazione Telethon
    Inventors: Luigi Naldini, Angelo Leone Lombardo, Angelo Amabile, Alessandro Migliara
  • Permanent Epigenetic Gene Silencing
    Publication number: 20230340471
    Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).
    Type: Application
    Filed: October 11, 2022
    Publication date: October 26, 2023
    Inventors: Luigi Naldini, Angelo Leone Lombardo, Angelo Amabile, Alessandro Migliara
  • Permanent Epigenetic Gene Silencing
    Publication number: 20190032049
    Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).
    Type: Application
    Filed: October 23, 2015
    Publication date: January 31, 2019
    Inventors: Luigi Naldini, Angelo Leone Lombardo, Angelo Amabile, Alessandro Migliara