Patents by Inventor Angelo Bedeschi

Angelo Bedeschi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8247426
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: August 21, 2012
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Patent number: 7935818
    Abstract: A process for the preparation of valgancyclovir which comprises: a) reacting a compound of formula 7, in an aprotic solvent, in the presence of a condensing agent, with a compound of formula 8, wherein R1, and R2 may be, each independently, hydrogen, an halogen atom or an hydroxyl group; the double bond may either be in the E or Z configuration or a mixture thereof to yield a compound of formula 9 b) mild hydrolysis of compound obtained in a) to give valgancyclovir.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: May 3, 2011
    Assignee: Fidia Farmaceutici S.p.A.
    Inventors: Gianluca Belogi, Alessia Rossi, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20100179180
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 15, 2010
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni POZZI, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20090275766
    Abstract: The invention relates to processes for the preparation of tigecycline (I): a wide spectrum antibiotic belonging to the tetracycline family, in stable amorphous form, by freeze-drying, antisolvent precipitation and nebulization.
    Type: Application
    Filed: May 4, 2009
    Publication date: November 5, 2009
    Inventors: Giovanni POZZI, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20090192184
    Abstract: The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia) Herein referred to as forms ? and ?, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form ? can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form ? can be prepared starting from form ?.
    Type: Application
    Filed: December 3, 2008
    Publication date: July 30, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Andrea Mazzoni, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20090156863
    Abstract: The present invention discloses a process for the preparation of atomoxetine hydrochloride in a pure crystalline form, characterised by an XRPD spectrum as in FIG. 1. It is also object of the present invention to provide methods to obtain pure atomoxetine hydrochloride without the use of methylene chloride.
    Type: Application
    Filed: November 17, 2006
    Publication date: June 18, 2009
    Inventors: Luciana Malpezzi, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20080076923
    Abstract: A process for the preparation of valgancyclovir which comprises: a) reacting a compound of formula 7, in an aprotic solvent, in the presence of a condensing agent, with a compound of formula 8, wherein R1, and R2 may be, each independently, hydrogen, an halogen atom or an hydroxyl group; the double bond may either be in the E or Z configuration or a mixture thereof to yield a compound of formula 9 b) mild hydrolysis of compound obtained in a) to give valgancyclovir.
    Type: Application
    Filed: June 20, 2007
    Publication date: March 27, 2008
    Inventors: Gianluca Belogi, Alessia Rossi, Angelo Bedeschi, Roberta Pizzocaro
  • Patent number: 7273937
    Abstract: Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: September 25, 2007
    Assignee: Solmag S.p.A.
    Inventors: Samuele Frigoli, Claudio Fuganti, Stefano Serra, Francesco Pizzocaro, Angelo Bedeschi, Paolo Tubertini
  • Publication number: 20060205950
    Abstract: Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.
    Type: Application
    Filed: March 7, 2006
    Publication date: September 14, 2006
    Applicant: Solmag S.p.A.
    Inventors: Samuele Frigoli, Claudio Fuganti, Stefano Serra, Francesco Pizzocaro, Angelo Bedeschi, Paolo Tubertini
  • Patent number: 6420379
    Abstract: The present invention relates to alkynyl-substituted camptothecins of formula (I) wherein X, R1, R2 are as defined herein, and the pharmaceutically salts thereof. These compounds are useful in therapy as antitumor agents.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: July 16, 2002
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Ilaria Candiani, Angelo Bedeschi, Giuseppina Visentin, Maria Chiara Fagnola, Laura Capolongo
  • Patent number: 6403603
    Abstract: 9-Amino-20(S)-camptothecin (I) is prepared by reducing 12-nitro-20(S)-camptothecin (II); converting the resulting 12-amino-20(S)-camptothecin (III) into a compound of formula (IV) wherein X is a group which can be reductively removed; reacting the compound of formula (IV) with a nitrating agent, to obtain thereby the corresponding 9-nitro-20(S)-camptothecin compound of formula (V) substituted at the 12-position by the group X; reducing in a single step the compound of formula (V), so obtaining the 9-amino-20(S)-camptothecin of formula (I); or reducing the compound of formula (V), so obtaining the corresponding 9-amino-20(S)-camptothecin compound of formula (VI) substituted at the 12-position by the group X and reductively removing the X group from the compound of formula (VI), so obtaining 9-amino-20(S)-camptothecin.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: June 11, 2002
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Angelo Bedeschi, Walter Cabri, Ilaria Candiani, Franco Zarini
  • Patent number: 6211192
    Abstract: The present invention relates to alkynyl-substituted camptothecins of formula (I) wherein X, R1, R2 are as defined herein, and the pharmaceutically salts thereof. These compounds are useful in therapy as antitumor agents.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: April 3, 2001
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Ilaria Candiani, Angelo Bedeschi, Giuseppina Visentin, Maria Chiara Fagnola, Laura Capolongo
  • Patent number: 6093721
    Abstract: A water soluble camptothecin derivative which is 20(S)-7-ethyl-9(N-methyl-N-phenyl)amidino-camptothecin and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and a process for their preparation are described. The compound of the invention and its pharmaceutically acceptable salts are useful antitumor agents and are further charactcrised by having a remarkable therapeutic index.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: July 25, 2000
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Angelo Bedeschi, Walter Cabri, Ilaria Candiani, Laura Capolongo
  • Patent number: 5998426
    Abstract: The present invention relates to 9-amino-10-(1-naphthylsulfonyloxy)-20(S)-camptothecin, 9-amino-10-phenylsulfonyloxy-20(S)-camptothecin, 7-ethyl-9-amino-10-(p-toluensulfonyloxy)-20(S)-camptothecin, their pharmaceutically acceptable salts, a process for their preparation, pharmaceutically compositions comprising them and their use as antitumor agents.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: December 7, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Angelo Bedeschi, Walter Cabri, Ilaria Candiani, Franco Zarini, Sergio Penco
  • Patent number: 5990120
    Abstract: The present invention relates to novel hexacyclic camptohecin analogues, having a five-membered aza-heterocycle fused to ring (A) of camptothecin at positions 9 and 10. Such compounds possess high antitumor activity by inhibition of topoisomerase (I).
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: November 23, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Angelo Bedeschi, Ilaria Candiani, Franco Zarini
  • Patent number: 5919955
    Abstract: The present invention relates to a process for the generation of a plurality of different benzofuran derivatives, and to the use of said benzofuran derivatives to search for novel classes of compounds and individual compounds possessing selected properties for pharmaceutical applications.
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: July 6, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Daniele Fancelli, Dino Severino, Maria Chiara Fagnola, Angelo Bedeschi
  • Patent number: 5916897
    Abstract: The present invention relates to compounds of the following formulas: ##STR1## which are endowed with antitumor activity. The invention also relates to methods of treating tumors using these compounds.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: June 29, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Walter Cabri, Ilaria Candiani, Franco Zarini, Angelo Bedeschi, Sergio Penco
  • Patent number: 5856333
    Abstract: The present invention relates to substituted camptothecin derivatives of formula (I) wherein the symbol - - - - represents a single or double bond; R.sub.1, R.sub.2 and R.sub.3 are as defined under (a) or (b) below: (a) R.sub.1 and R.sub.2 are, each independently, hydrogen; C.sub.1 -C.sub.4 alkyl; C.sub.3 -C.sub.7 cycloalkyl; phenyl C.sub.1 -C.sub.6 alkyl; an optionally substituted phenyl ring; --NR.sub.5 R.sub.6 wherein one of R.sub.5 and R.sub.6 is hydrogen, C.sub.1 -C.sub.6 alkyl or benzyl and the other is hydrogen, C.sub.1 -C.sub.6 alkanoyl, an optionally substituted C.sub.1 -C.sub.6 alkoxycarbonyl, an optionally substituted benzoyl, phenyl C.sub.1 -C.sub.6 alkanoyl, an optionally substituted C.sub.1 -C.sub.6 alkoxycarbonyl, an optionally substituted phenoxycarbonyl or phenyl C.sub.1 -C.sub.6 alkoxycarbonyl, or R.sub.5 and R.sub.6, combined together with the nitrogen atom to which they are linked, form a 4-7 membered saturated, optionally substituted, heteromonocyclic ring residue; COOR.sub.8 wherein R.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: January 5, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Walter Cabri, Ilaria Candiani, Angelo Bedeschi, Franco Zarini, Sergio Penco
  • Patent number: 5856496
    Abstract: A process for preparing libraries of indole compounds by solid phase synthesis in the presence of organometallic catalysts. The resulting compounds have a very high purity degree, which allows biological testing on the crude products with a high confidence degree, without any cross contaminations.
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: January 5, 1999
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Maria Chiara Fagnola, Angelo Bedeschi, Ilaria Candiani, Giuseppina Visentin, Nicola Mongelli
  • Patent number: 5840899
    Abstract: 9-Amino camptothecin of formula (I) ##STR1## is prepared by: 1) reducing a compound of formula (II): ##STR2## wherein Hal is 10- or 12-halogen, in a single step to the 9-amino-camptothecin of formula (I) or, alternatively, 2a) reductively removing the Hal group from a compound of formula (II) so obtaining the compound of formula (III): ##STR3## and 2b) reducing the compound of formula (III) so obtaining the 9-amino camptothecin of formula (I); the said steps 1 and 2a) and, optionally, step 2b) each being carried out in the presence of a catalytic amount of a compound of formula PdL.sub.2 wherein L is acetate or halogen and, additionally, in the presence of an ammonium formate as a hydrogen source. The 9-amino camptothecin of formula (I) is useful as inhibitor of the enzyme topoisomerase I. It is useful in the treatment of cancers, in particular leukaemia, colon and rectal tumours.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: November 24, 1998
    Assignee: Pharmacia S.p.A.
    Inventors: Angelo Bedeschi, Walter Cabri, Ilaria Candiani, Franco Zarini