Patents by Inventor Angelo Castellino

Angelo Castellino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
    Patent number: 7297708
    Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., anxiety and depression, treatable by antagonizing CRF receptors.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: November 20, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Andreas Termin, Peter D. J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
  • Compositions and methods for increasing drug efficiency
    Publication number: 20060234909
    Abstract: In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.
    Type: Application
    Filed: March 14, 2006
    Publication date: October 19, 2006
    Inventors: Michael Newman, Angelo Castellino, Joel Desharnais, Zijian Guo, Qing Li, Carlo Ballatore, Chengzao Sun
  • Compositions and methods for increasing drug efficiency
    Publication number: 20050187147
    Abstract: In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.
    Type: Application
    Filed: September 22, 2004
    Publication date: August 25, 2005
    Inventors: Michael Newman, Angelo Castellino, Joel Desharnais, Zijian Guo, Qing Li, Carlo Ballatore, Chengzao Sun
  • Small molecule compositions and methods for increasing drug efficiency using compositions thereof
    Publication number: 20050148534
    Abstract: In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S??(1) or formula 2: D-L-S???(2) wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S? is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.
    Type: Application
    Filed: September 22, 2004
    Publication date: July 7, 2005
    Inventors: Angelo Castellino, Carlo Ballatore, Simon Aspland, Joel Desharnais, Michael Newman, Chengzao Sun, Peter Wirsching
  • Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
    Publication number: 20030229091
    Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): 1
    Type: Application
    Filed: September 5, 2002
    Publication date: December 11, 2003
    Inventors: Andreas Termin, Peter D.J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
  • Adenosine kinase inhibitors
    Patent number: 5864033
    Abstract: Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various conditions which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: January 26, 1999
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Clinton E. Browne, Bheemarao G. Ugarkar, Kevin M. Mullane, Harry E. Gruber, David A. Bullough, Mark D. Erion, Angelo Castellino