Abstract: The object of the present invention is Udonitrectag (or Negermin or MTS. IUPAC name (1S,4R,5R,7S)-3,4-dibenzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylic acid lysine salt) and pharmaceutical formulation thereof for topical use for use in the treatment of dermatological diseases. i.e. of the skin and mucous membranes.

Abstract: A transmucosal delivery composition in form of a sublingual orally dispersible film comprising cladribine as active ingredient and comprising at least two hydrophilic polymers, wherein the at least two hydrophilic polymers represent at least 20% (w/w) of the total composition, wherein cladribine is contained in the composition as a cladribine-cyclodextrin complex. Said composition for use in the treatment of multiple sclerosis (MS), myasthenia gravis (MG), neuromyelitis optica spectrum disorders (NMOSD). A method for producing a transmucosal delivery composition in form of a sublingual orally dispersible film, wherein cladribine or cladribine-cyclodextrin complex is mixed with film-forming polymers by stirring with at least 100 rpm for at least 10 min at a temperature of at least 30° C.

Abstract: The invention discloses a transmucosal delivery composition in form of a sublingual orally dispersible film comprising cladribine as active ingredient.

Abstract: The invention proposes a tubular door lock of the type comprising essentially an elongated box casing for containing a control slide for the bolt, and provided with a plug which can be controlled from the outside for its positioning into a first inactive position in which said plug does not interfere with the path of said slide, and into a second active position in which said plug interferes with said path, and vice versa.

Abstract: Cam operated lock comprises a latch mobile against a spring along a tubular guide. The latch is operated by way of a cam which can be rotated against a spring by a manually operating member, preferably a handle. The handle needs to be turned through only a small angle for opening the lock. The lock can be fitted to both right hand and left hand opening doors with little adaptation, and in both these positions the lock is opened by turning the handle downwards.