Patents by Inventor Angelo Guglielmotti

Angelo Guglielmotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
    Patent number: 8283348
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: October 9, 2012
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
  • PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED INFLAMMATORY DISEASES
    Publication number: 20120220636
    Abstract: The present invention relates to a pharmaceutical composition comprising a combination of 1-benzyl-3-hydroxymethyl-indazole derivative, a pressure lowering agent selected from ACE-inhibitors, renin inhibitors, ARBs and CCBs, and/or a cholesterol lowering agent selected from statin derivatives. The combination showed an additive and synergistic activity in reducing MCP-1 levels, thus significantly improving inflammatory response inhibition and consequently reducing complications occurring in patients suffering from inflammatory diseases.
    Type: Application
    Filed: September 3, 2010
    Publication date: August 30, 2012
    Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F.S.p.A.
    Inventors: Angelo Guglielmotti, Beatrice Garrone, Alessandro Ble', Giuseppe Biondi, Roberta Petrosemolo, Enrica Biondi, Iacopo Biondi
  • Use of an indazolemethoxyalkanoic acid for reducing triglyceride, cholesterol and glucose levels
    Patent number: 8198310
    Abstract: Use of a compound of formula (I) in which R, R? and R? have the meanings given in the description, optionally in the form of a salt thereof with a pharmaceutically acceptable organic or mineral base, to prepare a pharmaceutical composition for reducing the blood triglyceride, cholesterol and glucose levels.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: June 12, 2012
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.p.A.
    Inventors: Angelo Guglielmotti, Giuseppe Biondi
  • 2-arylindole derivatives as nPGES-1 inhibitors
    Patent number: 8017644
    Abstract: A 2-arylindole compound substituted in position 5, of formula (I): in which X, Y, Z, W, A, R and R? have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: September 13, 2011
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Barbara Garofalo, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Isabella Coletta, Lorenzo Polenzani, Giorgina Mangano, Beatrice Garrone, Angelo Guglielmotti
  • NOVEL 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40
    Publication number: 20110160205
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
    Type: Application
    Filed: March 7, 2011
    Publication date: June 30, 2011
    Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.
    Inventors: Angelo GUGLIELMOTTI, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
  • COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT
    Publication number: 20110160201
    Abstract: Compound of formula (I) in which R1, R2 and R3 are defined in the following description, and the pharmaceutically acceptable acid-addition or base-addition salts thereof. The invention also relates to a process and an intermediate for preparing it, and to a pharmaceutical composition comprising it. The invention also relates to the use of a novel 2H-pyrrolo[3,4-c]quinoline compound for preparing a pharmaceutical composition that is active in the treatment of disturbances of the serotoninergic system.
    Type: Application
    Filed: July 17, 2009
    Publication date: June 30, 2011
    Applicant: AZIENDE CHIMI. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Roberta Costi, Roberto Di Santo, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
  • 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40
    Publication number: 20110082141
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
    Type: Application
    Filed: March 5, 2009
    Publication date: April 7, 2011
    Applicant: AZIENDE CHIM. RIUN.ANG.FRANC. A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla
  • 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
    Patent number: 7919518
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: April 5, 2011
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
  • 3-AMINOCARBAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING IT AND PREPARATION METHOD THEREFOR
    Publication number: 20110060025
    Abstract: The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.
    Type: Application
    Filed: May 11, 2009
    Publication date: March 10, 2011
    Applicant: AZIENDE CHIM. RIUN.ANG.FRANC. A.C.R.A.F S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Isabella Coletta, Patrizia Dragone, Guido Furlotti, Barbara Garofalo, Angelo Guglielmotti, Giorgina Mangano, Caterina Maugeri
  • Pharmaceutical composition comprising a 1-(3-chlorophenyl)-3-alkylpiperazine for treating appetite disorder
    Patent number: 7879836
    Abstract: Use of a 1-(3-chlorophenyl)-3-alkylpiperazine of formula (I), in racemic (R,S) form or in the form of the (S) enantiomer, in which R is a linear or branched alkyl group having from 1 to 3 carbon atoms, or of an addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, for treating appetite disorder. A pharmaceutical composition that comprises a therapeutically effective amount of a 1-(3-chlorophenyl)-3-alkylpiperazine of formula (I) as previously defined or of an addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, and at least one pharmaceutically acceptable excipient.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: February 1, 2011
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Beatrice Garrone, Maurizio Magnani, Guido Furlotti, Nicola Cazzolla, Angelo Guglielmotti
  • NOVEL 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40
    Publication number: 20110003874
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
    Type: Application
    Filed: March 5, 2009
    Publication date: January 6, 2011
    Applicant: Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
  • 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1 AND CX3CR1
    Publication number: 20100317618
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of novel 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1 and CX3CR1, and to their use in a method for treating or preventing diseases based on the expression of MCP-1 and CX3CR1.
    Type: Application
    Filed: March 6, 2009
    Publication date: December 16, 2010
    Applicant: AZIENDE CHIM. RIUN. ANGEL. FRA. A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla
  • NOVEL 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40
    Publication number: 20100311744
    Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
    Type: Application
    Filed: March 5, 2009
    Publication date: December 9, 2010
    Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
  • DRUG ACTIVE IN NEUROPATHIC PAIN
    Publication number: 20100215742
    Abstract: The present invention relates to a compound of formula (I): in which: R is a linear or branched alkyl group containing between 1 and 3 carbon atoms, Y is CH or N, and p is an integer between 0 and 3 and preferably 0 and 1, and salts thereof, either acid-addition salts with a pharmaceutically acceptable organic or mineral acid, or base-addition salts with a pharmaceutically acceptable organic or mineral base. The invention also relates to a process for preparing the compound of formula (I), and to a pharmaceutical composition comprising it. The invention also relates to the use of an indazole for preparing a pharmaceutical composition that is active in the treatment of neuropathic pain.
    Type: Application
    Filed: November 6, 2008
    Publication date: August 26, 2010
    Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
  • INDAZOLE HAVING ANALGESIC ACTIVITY
    Publication number: 20100094015
    Abstract: An intermediate of formula (II)
    Type: Application
    Filed: December 15, 2009
    Publication date: April 15, 2010
    Applicant: AZIENDE CHIM. RIUN. ANGEL. FRA. A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
  • USE OF AN INDAZOLEMETHOXYALKANOIC ACID FOR REDUCING TRIGLYCERIDE, CHOLESTEROL AND GLUCOSE LEVELS
    Publication number: 20100069456
    Abstract: Use of a compound of formula (I) in which R, R? and R? have the meanings given in the description, optionally in the form of a salt thereof with a pharmaceutically acceptable organic or mineral base, to prepare a pharmaceutical composition for reducing the blood triglyceride, cholesterol and glucose levels.
    Type: Application
    Filed: November 13, 2007
    Publication date: March 18, 2010
    Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R. A.F. S.P.A.
    Inventors: Angelo Guglielmotti, Giuseppe Biondi
  • INDAZOLAMIDES WITH ANALGESIC ACTIVITY
    Publication number: 20100048907
    Abstract: The present invention relates to compounds of formula (II)
    Type: Application
    Filed: October 28, 2009
    Publication date: February 25, 2010
    Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A.
    Inventors: Maria Alessandra ALISI, Nicola Cazzolla, Angelo Guglielmotti, Guido Furlotti, Giuseppe Luna, Lorenzo Polenzani
  • Indazole having analgesic activity
    Patent number: 7662836
    Abstract: An indazole having analgesic activity, a method for the preparation thereof and a pharmaceutical composition containing the same; the indazole has the following general formula: where X, Ra, Rb, Rc and Rd have the meanings stated in the description.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: February 16, 2010
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
  • Use of indazole derivatives for the treatment of neuropathic pain
    Patent number: 7638534
    Abstract: Use of a compound of formula (I), wherein X is CH or N, and when X is CH, R is H, OH, a linear or branched alkyl chain having from 1 to 3 carbon atoms, a linear or branched alkoxy chain having from 1 to 3 carbon atoms, or a halogen atom, and when X is N, R is H, or an acid addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, to prepare a pharmaceutical composition active in the treatment of neuropathic pain.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: December 29, 2009
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Lorenzo Polenzani, Alessandra Alisi, Nicola Cazzolla
  • Indazolamides with analgesic activity
    Patent number: 7632849
    Abstract: An indazolamide (I), wherein X, R1, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the description, and addition salts thereof with a pharmaceutically acceptable acid, a method for the preparation thereof and a pharmaceutical composition containing the same.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: December 15, 2009
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Angelo Guglielmotti, Guido Furlotti, Giuseppe Luna, Lorenzo Polenzani