Patents by Inventor Angelo J. Castellino

Angelo J. Castellino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-10 carbamates of taxanes
    Patent number: 8138361
    Abstract: Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: March 20, 2012
    Assignees: The Trustees Of The University Of Pennsylvania, Acidophil, LLC
    Inventors: Carlo Ballatore, Angelo J Castellino, Amos B Smith, III, Joel Desharnais, Chengzao Sun, Simon E Aspland
  • C-10 CARBAMATES OF TAXANES
    Publication number: 20090306014
    Abstract: Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy.
    Type: Application
    Filed: December 27, 2006
    Publication date: December 10, 2009
    Applicants: Acidophil llc, The Trustees of the University of Pennsylvania
    Inventors: Carlo Ballatore, Angelo J. Castellino, Amos B. Smith, III, Joel Desharnais, Chengzao Sun, Simon E. Aspland
  • Orally active adenosine kinase inhibitors
    Patent number: 5763597
    Abstract: This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to orally active, substituted 5-aryl pyrrolo?2,3-d! pyrimidine and 3-aryl pyrazolo?3,4-d! pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention also relates to the preparation and use of these and other adenosine kinase inhibitors in the treatment of cardiovascular and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: June 9, 1998
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Bheemarao G. Ugarkar, Mark D. Erion, Jorge E. Gomez Galeno, Angelo J. Castellino, Clinton E. Browne
  • Orally active adenosine kinase inhibitors
    Patent number: 5721356
    Abstract: This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to orally active, substituted 5-aryl pyrrolo?2,3-d!pyrimidine and 3-aryl pyrazolo?3,4-d! pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention also relates to the preparation and use of these and other adenosine kinase inhibitors in the treatment of cardiovascular and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Gensia, Inc.
    Inventors: Bheemarao G. Ugarkar, Mark D. Erion, Jorge E. Gomez Galeno, Angelo J. Castellino, Clinton E. Browne
  • Methods for treating adenosine kinase related conditions
    Patent number: 5646128
    Abstract: Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: July 8, 1997
    Assignee: Gensia, Inc.
    Inventors: Gary S. Firestein, Bheemarao G. Ugarkar, Leonard P. Miller, Harry E. Gruber, David A. Bullough, Mark D. Erion, Angelo J. Castellino, Clinton E. Browne
  • Lyxofuranosyl analogues of adenosine
    Patent number: 5506347
    Abstract: Novel lyxose derivatives which selectively inhibit adenosine kinase and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions in vivo which may be ameliorated by increased local concentrations of adenosine.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: April 9, 1996
    Assignee: Gensia, Inc.
    Inventors: Mark D. Erion, Bheemarao G. Ugarkar, Angelo J. Castellino