Patents by Inventor Angelo M. Delegeane
Angelo M. Delegeane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6927056Abstract: The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.Type: GrantFiled: September 6, 2001Date of Patent: August 9, 2005Assignee: Incyte CorporationInventors: Stephen Todd, Angelo M. Delegeane, Ameena R. Gandhi, Danniel B. Nguyen, April J. A. Hafalia, Liam Kearney, Yan Lu, Ernestine A. Lee, Narinder K. Chawla, Debopriya Das, Chandra S. Arvizu, Monique G. Yao, Deborah A. Kallick, Vicki S. Elliott, Li Ding, Henry Yue, Roopa M. Reddy, Dyung Aina M. Lu, Jayalaxmi Ramkumar, Junming Yang, Catherine M. Tribouley, Neil Burford, Mariah R. Baughn, Preeti G. Lal, Mark L. Borowsky, Farrah A. Khan, Rajagopal Gururajan, Y. Tom Tang, Janice K. Au-Young, Bridget A. Warren, Roberto Hernandez, Brendan M. Duggan
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Publication number: 20040253598Abstract: Various embodiments of the invention provide human vesicle-associated proteins (VAP) and polynucleotides which identify and encode VAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of VAP.Type: ApplicationFiled: March 31, 2004Publication date: December 16, 2004Inventors: Mariah R. Baughn, Ernestine A. Lee, Vicki S. Elliott, Brendan M. Duggan, Joana X. Li, Jennifer A. Griffin, April J.A. Hafalia, Angelo M. Delegeane, Soo Yeun Lee, Jayalaxmi Ramkumar, Amy E. Kable, Joseph P. Marquis, Rajagopal Gururajan, William W. (Webb) Sprague, Junming Yang, Kimberly J. Gietzen, Yeganeh Zebarjadian, Thomas W. Richardson, Alan A. Jackson, Xin Jiang, Shanya D. Becha
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Publication number: 20040091962Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: January 21, 2003Publication date: May 13, 2004Inventors: Angelo M Delegeane, Ameena R Gandhi, April J A Hafalia, Dyung Aina M Lu, Chandra S Arvizu, Catherine M Tribouley, Debopriya Das, Deborah A Kallick, Danniel B Nguyen, Ernestine A Lee, Farrah A Khan, Henry Yue, Janice K Au-Young, Jennifer A Griffin, Jennifer L Policky, Jayalaxmi Ramkumar, Junming Yang, Kavitha Thangavelu, Li Ding, Liam Kearney, Mariah R Baughn, Mark L Borowsky, Madhusudan M Sanjanwala, Monique G Yao, Neil Burford, Narinder K Chawla, Preeti G Lal, Sally Lee, Stephen Todd, Terence P Lo, Y Tom Tang, Vicki S Elliott, Yalda Azimzai, Yan Lu
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Publication number: 20040081961Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: May 16, 2003Publication date: April 29, 2004Inventors: Angelo M Delegeane, Preeti G Lal, April J A Hafalia, Chandra S Patterson, Narinder K Walia, Liam Kearney, Catherine M Tribouley, Farrah A Khan, Monique G Yao, Mariah R Baughn, Yalda Azimzai, Vicki S Elliott, Danniel B Nguyen, Ammena R Gandhi, Junming Yang, Roberto Hernandez, Jennifer L Policky, Dyung Aina M Lu, Roopa M Reddy, Henry Yue, Y Tom Tang
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Publication number: 20040081971Abstract: The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMM.Type: ApplicationFiled: December 19, 2002Publication date: April 29, 2004Inventors: Henry Yue, Preeti G Lal, Narinder K Chawla, Y Tom Tang, Dyung Aina M Lu, Monique G Yao, Danniel B Nguyen, April J A Hafalia, Chandra S Arvizu, Angelo M Delegeane, Yan Lu, Nei Burford, Jennifer L Policky, Ameena R Gandhi, Jayalaxmi Ramkumar, Farrah A Khan, Kavitha Thangavelu, Yuming Xu, Kimberly J Gietzen
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Publication number: 20040077048Abstract: The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.Type: ApplicationFiled: July 31, 2003Publication date: April 22, 2004Inventors: Bridget A. Warren, Cynthia D. Honchell, Yan Lu, Narinder K. Chawla, Neil Burford, Angelo M. Delegeane, Ameena R. Gandhi, Mariah R. Baughn, Jennifer A. Griffin, Kimberly J. Gietzen, Dyung Aina M. Lu, Craig H. Ison, Jayalaxmi Ramkumar, Y Tom Tang, Preeti G. Lal, Mark L. Borowsky, Brendan M. Duggan, April J A Hafalia, Chandra S. Arvizu, Kavitha Thangavelu, Monique G. Yao, Vicki S. Elliott, Li Ding, Henry Yue, Sally Lee, Anita Swarnakar, Uyen K. Tan, Yuming Xu
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Publication number: 20040053824Abstract: The invention provides human extracellular matrix and cell adhesion molecules (ECMCAD) and polynucleotides which identity and encode ECMCAD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ECMCAD.Type: ApplicationFiled: December 18, 2002Publication date: March 18, 2004Inventors: Y Tom Tang, Henry Yue, Yalda Azimzai, Ann He, Terence P Lo, Daniel B Nguyen, John D Burrill, Gregory A Marcus, Kurt A Zingler, Ameena R Gandhi, Liam Kearney, Neil Burford, Monique G Yao, Narinder K Chawla, Vicki S Elliott, Chandra S Arvizu, Mariah R Baughn, April J A Hafalia, Jennifer L Policky, Janice K Au-Young, Yan Lu, Mark L Borowsky, Dyung Aina M Lu, Jayalaxmi Ramkumar, Junming Yang, Rajagopal Gururajan, Bridget A Warren, Kimberly J Gietzen, Yuming Xu, Deborah A Kallick, Ernestine A Lee, Kavitha Thangavelu, Angelo M Delegeane, Sally Lee, Sajeev Batra, Preetr G. Lal, Farrah A. Khan
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Publication number: 20040053269Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: March 4, 2003Publication date: March 18, 2004Inventors: Stephen Todd, Angelo M Delegeane, Ameena R Gandhi, Danniel B Nguyen, April J A Hafalia, Liam Kearney, Yan Lu, Ernestine A Lee, Narinder K Chawla, Debopriya Das, Chandra S Arvizu, Monique G Yao, Deborah A Kallick, Vicki S Elliott, Li Ding, Henry Yue, Roopa M Reddy, Dyung Aina M Lu, Jayalaxmi Ramkumar, Junming Yang, Catherine M Tribouley, Neil Burford, Mariah R Baughn, Preeti G Lal, Mark L Borowsky, Farrah A Khan, Rajagopal Gururajan, Y Tom Tang, Janice K Au-Young, Bridget A Warren, Roberto Hernandez, Brendan M Duggan
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Publication number: 20040029249Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: April 16, 2003Publication date: February 12, 2004Inventors: Ernestine A Lee, April J A Hafalia, Henry Yue, Preeti G Lal, Monique G Yao, Yan Lu, Narinder K Chawla, Bridget A Warren, Dyung Aina M Lu, Mariah R Baughn, Angelo M Delegeane, Neil Burford, Mark L Borowsky, Sally Lee, Yuming Xu, Jennifer A Griffin, Deborah A Kallick, Ameena R Gandhi, Chandra S Arvizu, Craig H Ison, Y Tom Tang, Yalda Azimzai, Vicki S Elliott, Anita Swarnakar, Jayalaxmi Ramkumar, Danniel B Nguyen, Catherine M Tribouley, Terence P Lo, Janice K Au-Young, Kavitha Thangavelu, Liam Kearney
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Publication number: 20040023243Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: May 19, 2003Publication date: February 5, 2004Inventors: Yue Henry, Vicki S Elliott, Ameena R Gandhi, Preeti G Lal, Janice Au-Young, Catherine M Tribouley, Angelo M Delegeane, Mariah R Baughn, Danniel B Nguyen, Ernestine A Lee, April J A Hafalia, Farrah A Khan, Narinder K Chawla, Monique G Yao, Dyung Aina M Lu, Chandra S Arvizu, Y Tom Tang, Roderick T Walsh, Yalda Azimzai, Yan Lu, Jayalaxmi Ramkumar, Yuming Xu, Roopa Reddy, Debopriya Das, Liam Kearney, Deborah A Kallick
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Publication number: 20030232349Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: October 18, 2002Publication date: December 18, 2003Applicant: Incyte Genomics, Inc.Inventors: Angelo M. Delegeane, Ameena R. Gandhi, April J. A. Hafalia, Dyung Aina M. Lu, Chandra S. Arvizu, Catherine M. Tribouley, Debopriya Das, Deborah A. Kallick, Danniel B. Nguyen, Ernestine A. Lee, Farrah A. Khan, Henry Yue, Janice Au-Young, Jennifer A. Griffin, Jennifer L. Policky, Jayalaxmi Ramkumar, Junming Yang, Kavitha Thangavelu, Li Ding, Liam Kearney, Mariah R. Baughn, Mark L. Borowsky, Madhusudan Sanjanwala, Monique G. Yao, Neil Burford, Narinder K. Chawla, Preeti G. Lal, Sally Lee, Stephen Todd, Terence P. Lo, Y. Tom Tang, Vicki S. Elliott, Yalda Azimzai, Yan Lu
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Publication number: 20030215822Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.Type: ApplicationFiled: November 15, 2002Publication date: November 20, 2003Inventors: Jennifer A. Griffin, Monique G. Yao, Christopher M. Bruns, Henry Yue, Angelo M. Delegeane, April Hafalia, Chandra Arvizu, Jennifer L. Policky, Catherine M. Tribouley, Mariah R. Baughn, Danniel B. Nguyen, Preeti Lal, Y. Tom Tang, Jennifer L. Hillman, Dyung Aina M. Lu, Sajeev Batra, Janice Au-Young, Roopa Reddy, Yalda Azimzai
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Publication number: 20030040615Abstract: The present invention provides purified polynucleotides, complements and fragments thereof, identified as encoding or regulating electron transfer molecules. The invention also provides for the use of these polynucleotides in methods to produce polypeptides and in the diagnosis, study, prevention, and treatment of disorders.Type: ApplicationFiled: March 24, 2000Publication date: February 27, 2003Inventors: Jeffrey J. Seilhamer, Angelo M. Delegeane, Susan G. Stuart, Laura L. Stuve, Sara J. Mullahy, Rebecca E. Naughton
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Publication number: 20020155535Abstract: The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.Type: ApplicationFiled: September 28, 2001Publication date: October 24, 2002Applicant: Incyte Pharmaceuticals, Inc.Inventors: Dinh Diep, Scott Michael Braxton, Angelo M. Delegeane
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Publication number: 20020064792Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.Type: ApplicationFiled: September 19, 2001Publication date: May 30, 2002Inventors: Stephen E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
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Patent number: 6303297Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.Type: GrantFiled: November 13, 1997Date of Patent: October 16, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Steve E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
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Patent number: 6030791Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.Type: GrantFiled: September 15, 1998Date of Patent: February 29, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Scott M. Braxton, Dinh Diep, Angelo M. Delegeane
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Patent number: 6007997Abstract: The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.Type: GrantFiled: November 17, 1998Date of Patent: December 28, 1999Assignee: Incyte Pharmaceuticals, Inc.Inventors: Dinh Diep, Scott Michael Braxton, Angelo M. Delegeane
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Patent number: 5856109Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.Type: GrantFiled: November 7, 1997Date of Patent: January 5, 1999Assignee: Incyte Pharmaceuticals, Inc.Inventors: Scott M. Braxton, Dinh Diep, Angelo M. Delegeane
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Patent number: 5840562Abstract: The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.Type: GrantFiled: September 12, 1997Date of Patent: November 24, 1998Assignee: Incyte Pharmaceuticals, Inc.Inventors: Dinh Diep, Scott Michael Braxton, Angelo M. Delegeane