Abstract: An endotracheal tube is equipped for delivering a drug externally of the tube. The endotracheal tube includes a tube body having proximal end and distal ends, and at least one flexible irrigation cannula extending along the endotracheal tube body to its distal end. An irrigation diffuser means is attached to the irrigation cannula for spraying a drug delivered through the irrigation cannula externally of the endotracheal tube body. The endotracheal tube is particularly intended for artificial ventilation in surgical operations and in intensive resuscitation treatments. It is useful for the repeated administration and re-administration of drugs, for instance, of local anesthetics, anti-inflammatories and mucolytics in the course of intubation.