Patents by Inventor Angelo S. Mao

Angelo S. Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RIBOSWITCH MODULES AND METHODS FOR CONTROLLING EUKARYOTIC PROTEIN TRANSLATION
    Publication number: 20230212592
    Abstract: The present disclosure provides genetic constructs comprising a recombinant internal ribosome entry site (IRES), which may be used as riboswitches to modulate translation of an operably-mRNA sequence encoding a protein of interest. In other aspects, the disclosure provides recombinant cells, methods, kits and systems that utilize the same, e.g., to provide a platform for modulating the expression of essentially any protein of interest in a eukaryotic cell.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 6, 2023
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: James J. COLLINS, Evan M. ZHAO, Xiao TAN, Fei RAN, Angelo S. MAO, Helena DE PUIG GUIXE, Emma J. CHORY
  • HYDROGEL COMPOSITIONS COMPRISING ENCAPSULATED CELLS AND METHODS OF USE THEREOF
    Publication number: 20220202727
    Abstract: The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compostions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 30, 2022
    Inventors: Jae-Won Shin, Angelo S. Mao, Stefanie Utech, David A. Weitz, David J. Mooney, Oktay R. Uzun
  • BIOENGINEERED SCAFFOLDS FOR MODULATION OF IMMUNE SYSTEM AND THE USES THEREOF
    Publication number: 20220047778
    Abstract: The present invention provides compositions and methods that modulate the immune system in a subject.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 17, 2022
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Nisarg J. Shah, Angelo S. Mao, Matthew D. Kerr, David J. Mooney, David T. Scadden
  • Hydrogel compositions comprising encapsulated cells and methods of use thereof
    Patent number: 11229607
    Abstract: The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: January 25, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Jae-Won Shin, Angelo S. Mao, Stefanie Utech, David A. Weitz, David J. Mooney, Oktay Uzun
  • DNA-RESPONSIVE HYDROGELS, METHODS OF ALTERING A PROPERTY OF A HYDROGEL, AND APPLICATIONS THEREOF
    Publication number: 20200308577
    Abstract: Disclosed herein are hydrogels comprising a polynucleotide-based structural component. Methods of altering a property of a hydrogel based on user-defined nucleic acid input sequences are also disclosed. In addition, various applications are described that utilize these hydrogels and methods.
    Type: Application
    Filed: January 31, 2020
    Publication date: October 1, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: James J. Collins, Helena de Puig Guixe, Luis Soenksen Martinez, Max English, Raphael Gayet, Nicolaas Angenent-Mari, Angelo S. Mao, Peter Q. Nguyen
  • COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE
    Publication number: 20200206333
    Abstract: Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic stem and progenitor cells. It is a devastating disease with a poor prognosis and an average 5-year survival rate of about 30%. Disclosed herein are composition and methods for treating leukemia with a biomaterial comprising a polymer scaffold, a dendritic cell activating factor, a dendritic cell recruitment factor, and at least one leukemia antigen. The biomaterial-based vaccine disclosed herein promotes a potent, durable and transferable immune response against acute myeloid leukemia to prevent cell engraftment and synergizes with chemotherapy to prevent relapse.
    Type: Application
    Filed: December 9, 2019
    Publication date: July 2, 2020
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Nisarg J. Shah, Ting-Yu Shih, Angelo S. Mao, David J. Mooney, David T. Scadden
  • MICROPARTICLES, METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20200085753
    Abstract: The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.
    Type: Application
    Filed: September 19, 2019
    Publication date: March 19, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Weitz, Stefanie Utech, Esther Amstad, Raluca Ostafe, Angelo S. Mao, David J. Mooney, Connie Chang Wilking, Huanan Wang, Radivoje Prodanovich
  • Microparticles, methods for their preparation and use
    Patent number: 10471016
    Abstract: The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: November 12, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, David A. Weitz, Stefanie Utech, Radivoje Prodanovich, Esther Amstad, Raluca Ostafe, Angelo S. Mao, Connie Chang Wilking, Huanan Wang
  • MICROPARTICLES, METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20180214385
    Abstract: The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.
    Type: Application
    Filed: March 8, 2018
    Publication date: August 2, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: David J. Mooney, David A. Weitz, Stefanie Utech, Radivoje Prodanovich, Esther Amstad, Raluca Ostafe, Angelo S. Mao, Connie Chang Wilking, Wang Huanan
  • HYDROGEL COMPOSITIONS COMPRISING ENCAPSULATED CELLS AND METHODS OF USE THEREOF
    Publication number: 20170196818
    Abstract: The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
    Type: Application
    Filed: June 30, 2015
    Publication date: July 13, 2017
    Inventors: Jae-Won Shin, Angelo S. Mao, Stefanie Utech, David A. Weitz, David J. Mooney, Oktay Uzun
  • MICROPARTICLES, METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20160279068
    Abstract: The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 29, 2016
    Inventors: Stefanie Utech, Radivoje Prodanovic, Esther Amstad, Raluca Ostafe, David A. Weitz, Angelo S. Mao, David J. Mooney, Connie Chang Wilking, Wang Huanan