Abstract: Methods and systems for monitoring heart valve operation using signals detected by a heart sound sensor includes memory to store program instructions and one or more processors that, when executing the program instructions receive seismocardiography (SCG) signals detected by a heart sound sensor along an axis. The SCG signals include heart sound signals for a series of heartbeats over a first time period. The SCG signals are segmented into SCG segments for corresponding heartbeats within the series of heartbeats over the first time period. A template is calculated based on a first subset of the SCG segments. At least a portion of a second subset of the SCG segments are compared to the template to determine matching scores, and an alert is generated in response to a select number of the second subset of SCG segments having the matching scores that satisfy a matching threshold.

Abstract: An implantable medical device (IMD) for managing therapy is provided that can include a lead with an electrode, a memory configured to store program instructions and one or more processors. The one or more processors can be configured to execute the program instructions to determine a sensed right atrium (RAs) event or a paced right atrial (RAp) event (RAs,p event), determine a sensed right ventricle (RVs) event by detecting a cardiac activity (CA) signal reaches a threshold amplitude and determining a maximum amplitude in a determined period of time after the CA signal reaches the threshold amplitude, and determine an RAs,p-RVs interval between the RAs,p event and RVs event. The one or more processors can also be configured to calculate an atrioventricular delay (AV) delay based on the RAs,p-RVs interval, and manage therapy, provided by the IMD, based on the AV delay that is calculated.