Patents by Inventor Angelo Spreafico

Angelo Spreafico has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Levalbuterol hydrochloride polymorph B
    Patent number: 7488758
    Abstract: The invention is directed to levalbuterol HCl Form B and methods of making the same.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 10, 2009
    Assignee: Teva Pharmaceutical Fine Chemicals, S.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Levalbuterol hydrochloride Polymorph A
    Patent number: 7465831
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: December 16, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals s.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Levalbuterol hydrochloride Polymorph A
    Publication number: 20080021244
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 24, 2008
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Levalbuterol hydrochloride Polymorph A
    Publication number: 20050272821
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 8, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Levalbuterol hydrochloride polymorph B
    Publication number: 20050267216
    Abstract: The invention is directed to levalbuterol HCl Form B and methods of making the same.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 1, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine
    Patent number: 5811586
    Abstract: A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: September 22, 1998
    Assignee: Alfa Chemicals Italiana S.P.A.
    Inventors: Vincenzo Cannata, Barbara Galbiati, Angelo Spreafico