Abstract: Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Abstract: Compounds of formula I: are antagonists of the human 5-HT2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions.

Abstract: A conventional SPR spectroscopic device, consisting of a metallic film used with a prism to provide a surface plasmon wave, is modified by coating the film with a dielectric layer. According to one aspect of the invention, such additional layer of dielectric material functions as an optical amplifier that produces an increased sensitivity and enhanced spectroscopic capabilities in SPR. According to another aspect of the invention, the added dielectric layer can be used as a matrix for adsorbing and immobilizing the sensing materials in sensor applications. Furthermore, the dielectric layer provides a shield for both mechanical and chemical protection of the metal layer, thereby preventing the rapid deterioration that commonly accompanies such detectors. In its simplest embodiment, the invention includes only one dielectric layer; in other embodiments, a variety of multi-layer configurations may be implemented for different purposes with diverse dielectric materials.

Abstract: A method for the formation of a biocompatible film composed of a self-assembled bilayer membrane deposited on a planar surface. This bilayer membrane is capable of immobilizing materials to be analyzed in an environment very similar to their native state. Materials so immobilized may be subject to any of a number of analytical techniques.