Abstract: Radar signal detection and parameter estimation is central in passive surveillance systems, providing inputs for many information processing modules in order to detect, localize, indentify and intercept hostile targets. The proposed method for detecting radar signals and estimating their intra-pulse parameters in time-varying noisy environments consists of several stages: magnitude-squared envelopes calculation, adaptive noise floor estimation, detection statistics calculation, rising edge detection, time of arrival estimation, falling edge detection, time of departure estimation, pulse width estimation, amplitude estimation and center frequency and bandwidth estimation. Estimated intra-pulse parameters are wrapped into pulse descriptor words (PDWs) for information processing tasks, where each PDW consists of time of arrival, time of departure, pulse width, pulse amplitude, center frequency, signal bandwidth, noise floor level and additional useful information.

Abstract: Novel 5? untranslated region (UTR)-targeting gene knock-in (KI) compositions and methods of use are disclosed. The gene KI compositions and methods exploit homology-independent targeted integration (HITI)-mediated insertion of a wild-type coding sequence (CDS) into the 5? UTR upstream of a translation initiation element of a mutated variant of the wild-type gene. The 5? UTR-targeting gene KI therapy compositions and methods provide safer and more efficient gene insertion compared to other gene therapy approaches.