Abstract: Compositions comprising multiple hydrogel particles having substantially the same diameter, but with each subgrouping of particles from the multiple hydrogel particles having different associated values for one or more passive optical properties that can be deconvoluted using cytometric instrumentation. Each hydrogel particle from the multiple hydrogel particles can be functionalized with a different biochemical or chemical target from a set of targets. A method of preparing hydrogel particles includes forming droplets and polymerizing the droplets, with optional functionalization.

Abstract: A digital-to-analog converter device including a set of components, each component included in the set of components including a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell is provided by the present disclosure. The digital-to-analog converter device further includes a plurality of switches, each switch included in the plurality of switches being coupled to a component included in the set of components, and an output electrode coupled to the plurality of switches. The digital-to-analog converter device is configured to output an output signal at the output electrode. A first unit cell size associated with a first unit cell included in the set of components is different than a second unit cell size associated with a second unit cell included in the set of components.

Abstract: Hydrogel beads with quantifiable attached biomolecules and their use as cell mimics in cytometric applications are described. The cell mimics described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell (e.g., CD34+ stem cell). The disclosure further relates to methods of using the disclosed cell mimics as enrichment controls in cytometric applications.

Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.

Abstract: Disclosed is a wrist-worn medical device. The wrist-worn medical device includes: an electrode strap, provided with conductive sponges, where the conductive sponges are configured for abutting against and conducting with conductive sheets; a connection strap, provided with the conductive sheets, where the connection strap is further electrically connected to a host, the conductive sheets are electrically connected to the host, and the host and the conductive sheets are respectively arranged on both sides of the connection strap along its thickness direction; and a limiting member, arranged on the connection strap, where when the connection strap abuts against the electrode strap, both the conductive sponges and the conductive sheets are located inside the limiting member.

Abstract: The present disclosure provides feeder hydrogel particles that can function to support the growth, proliferation, and/or activation of a target cell in culture. The present disclosure also provides methods of culturing target cells with feeder hydrogel particles.

Abstract: Provided herein are hydrogel beads that mimic live, dead, and apoptotic cells. The present disclosure also provides kits and compositions of hydrogel beads. The present disclosure further comprises methods of using the kits, compositions, and hydrogel beads to determine if a target cell sample includes one or more live, dead, or apoptotic cells.

Abstract: Disclosed are a wireless device authentication method, a system, a wearable medical device, and a product. The wireless device authentication method includes: responding to an authentication request from the target device to generate a first encrypted packet, and sending the first encrypted packet to the target device; receiving a second encrypted packet generated by the target device by modifying the data in the first encrypted packet after verifying the decrypted first encrypted packet has passed authentication; and determining that the target device has passed authentication when the second encrypted packet meets pre-set conditions, and responding to an encrypted instruction sent by the target device. The pre-set conditions include that the keys corresponding to the second encrypted packet and the first encrypted packet are the same and the second encrypted packet has passed integrity authentication.

Abstract: A system including a range extension system for extending a range of magnetic induction (MI) signals along a pathway for commercial/civil blasting operations that use a wireless blasting-related device, the range extension system including an elongated element configured to extend the range of the MI signals along the pathway.

Abstract: The present disclosure provides feeder hydrogel particles that can function to support the growth, proliferation, and/or activation of a target cell in culture. The present disclosure also provides methods of culturing target cells with feeder hydrogel particles.

Abstract: Provided herein are hydrogel beads that mimic live, dead, and apoptotic cells. The present disclosure also provides kits and compositions of hydrogel beads. The present disclosure further comprises methods of using the kits, compositions, and hydrogel beads to determine if a target cell sample includes one or more live, dead, or apoptotic cells.

Abstract: We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

Abstract: A neurostimulator incorporating a novel chip design that uses the principle of redundant signal crossfiring to overcome electronic component mismatch error in general and transistor mismatch error in particular, to yield superior quality neurostimulation signal generation, useful in enhancing the bidirectional human-machine interface in prosthesis operation for the restoration of somatosensation for an amputee.

Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.

Abstract: The present disclosure discloses a wristband nerve stimulator and a use method thereof. The wristband nerve stimulator is small in volume and wearable, and has a waterproof function. As a wristband instrument, the wristband nerve stimulator can perform treatment at any time. Furthermore, the fixed main unit and the band can be quickly mounted and removed, which is convenient to replace the band.

Abstract: Disclosed are a control circuit and control method for an electro-stimulation therapeutic instrument for neuromodulation. The control circuit includes a first switch, a second switch, a third switch, a fourth switch, a first signal end, a second signal end and a constant current source, where a first end of the first switch is connected to a power supply, and a second end of the first switch is connected to the first signal end; a first end of the second switch is connected to the power supply, and a second end of the second switch is connected to the second signal end; a first end of the third switch is connected to the first signal end, and a second end of the third switch is connected to the constant current source; and a first end of the fourth switch is connected to the second signal end.

Abstract: Disclosed is an H-bridge control circuit for an electro-stimulation therapeutic instrument for neuromodulation. The H-bridge control circuit includes an H-bridge circuit and a constant current source, where the H-bridge circuit includes a first positive channel metal oxide semiconductor (PMOS) transistor, a second PMOS transistor, a first negative channel metal oxide semiconductor (NMOS) transistor and a second NMOS transistor. Corresponding switching diodes are additionally arranged between the first PMOS transistor and a load and between the second PMOS transistor and the load to avoid an influence of safety of the therapeutic instrument by discharging charges during an interval of stimulation; and moreover, a resistance-capacitance (RC) circuit is additionally arranged between the first PMOS transistor, the second PMOS transistor and a control device such that connection and disconnection of the PMOS transistor can be controlled.

Abstract: A digital-to-analog converter device including a set of components, each component included in the set of components including a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell is provided by the present disclosure. The digital-to-analog converter device further includes a plurality of switches, each switch included in the plurality of switches being coupled to a component included in the set of components, and an output electrode coupled to the plurality of switches. The digital-to-analog converter device is configured to output an output signal at the output electrode. A first unit cell size associated with a first unit cell included in the set of components is different than a second unit cell size associated with a second unit cell included in the set of components.

Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.