Patents by Inventor Anica Markovac

Anica Markovac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-fluoro-9-trimethylsilyladenine
    Patent number: 5917040
    Abstract: A process for the preparation of 2-fluoro-9- (2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine (I) is described. The process involves reacting a protected 2-fluoro adenine with a protected chlorosugar under controlled conditions of temperature (80-85.degree. C.) to produce (I), rather than using a process involving fluorinating a 2-substituted nucleoside precursor of (I).
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: June 29, 1999
    Assignee: Ash Stevens, Inc.
    Inventors: Anica Markovac, Maurice P. LaMontagne
  • Process for the preparation of 2-amino (2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine
    Patent number: 5206351
    Abstract: A process for the preparation of 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl) adenine (V) is described. The process uses a protected 2,6-di(tri-alkylsilylamino)-9-trialkylsilylpurine (II) which is reacted with protected chlorosugar 2,3,5-tri-O-benzyl-1-chloro-D-arabinofuranose (III) and then the protection groups are removed from the 2 and 6 positions. The process provides a 9-beta-D-arabinofuranosyl-2-fluoroadenine (VII) which is an antileukenine drug.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: April 27, 1993
    Assignee: Ash Stevens, Inc.
    Inventors: Anica Markovac, Maurice P. LaMontagne
  • 2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials
    Patent number: 3953463
    Abstract: A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein diosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.
    Type: Grant
    Filed: September 16, 1974
    Date of Patent: April 27, 1976
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Arthur B. Ash, Maurice P. La Montagne, Anica Markovac
  • 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines
    Patent number: 3940404
    Abstract: A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein disclosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.
    Type: Grant
    Filed: September 17, 1974
    Date of Patent: February 24, 1976
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Arthur B. Ash, Maurice P. La Montagne, Anica Markovac