Abstract: According to an aspect of the present inventive concept there is provided an ingestible device for analysis of the gastrointestinal tract, the ingestible device comprising: at least one sensor configured for sensing a biochemical parameter, wherein the at least one sensor is configured to generate biochemical parameter data for identifying an anatomical localization of the ingestible device in the gastrointestinal tract, and a magnetic field sensor configured to receive an alternating magnetic field for generating spatial location data representing a spatial localization of the ingestible device, and wherein the ingestible device is configured to provide a combined localization of the ingestible device in the gastrointestinal tract based on the anatomical localization and the spatial localization.

Abstract: According to an aspect there is provided a method for identifying and localizing an unhealthy gut state in a gastrointestinal tract. The method comprises: receiving a first time series of data representing an unhealthy gut biomarker level and a second time series of data representing pH, wherein the time series are acquired by a sensor device while the device passes through the tract; identifying a first time point of a transition from a first to a second part of the tract based on value change of at least one of the first and second data; analyzing at least one of the time series, for identifying occurrence of the unhealthy gut state; and on if an occurrence of the unhealthy gut state is identified: determining a second time point of the occurrence of unhealthy gut state; and determining a location, along the gastrointestinal tract, of the unhealthy gut state based on the first and second time points.

Abstract: The current disclosure relates to methods and devices for measuring concentrations of analytes in the gastrointestinal tract of a subject by orally administering a smart pill to the subject, the smart pill comprising two or more sensors, a reference electrode, a power source, a communication interface and electronic circuits, each sensor being able to measure an analyte in the gastrointestinal tract of said subject, wherein the two or more sensors measure different analytes, measuring a concentration of two or more analytes using the two or more sensors, wherein one of the sensors is a pH sensor for measuring hydrogen ions, and wherein the pH sensor is able to locate the smart pill in the gastrointestinal tract by correlating the measured hydrogen ion concentration to a location in the gastrointestinal tract, and transmitting, using the communication interface, the measured concentrations from the two or more sensors to a base device located outside of the body of the subject.