Patents by Inventor Anikó Pálfi

Anikó Pálfi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amanitin antibody conjugates
    Patent number: 11446388
    Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: September 20, 2022
    Assignee: HEIDELBERG PHARMA RESEARCH GMBH
    Inventors: Torsten Hechler, Michael Kulke, Christian Lutz, Andreas Pahl, Christoph Müller, Werner Simon, Anikó Pálfi
  • AMANITIN ANTIBODY CONJUGATES
    Publication number: 20190328899
    Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.
    Type: Application
    Filed: December 22, 2017
    Publication date: October 31, 2019
    Inventors: Torsten Hechler, Michael Kulke, Christian Lutz, Andreas Pahl, Christoph Müller, Werner Simon, Anikó Pálfi