Patents by Inventor Aniko Takacs-Cox
Aniko Takacs-Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20190060345Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: February 22, 2018Publication date: February 28, 2019Inventors: Nancy HARRISON, I. David MACDONALD, Aniko TAKACS-COX, Robert MILLER
-
Patent number: 9931356Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: August 23, 2016Date of Patent: April 3, 2018Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Publication number: 20160361339Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: August 23, 2016Publication date: December 15, 2016Inventors: Nancy HARRISON, I. David MACDONALD, Aniko TAKACS-COX, Robert MILLER
-
Publication number: 20160228601Abstract: Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.Type: ApplicationFiled: August 27, 2015Publication date: August 11, 2016Inventors: Yuehua He, Aniko Takacs-Cox, Anthony BOey, Brent` Zaluski, Roger A. Smith, Audrey A. Deschamps, Rui Avelar
-
Patent number: 9326934Abstract: Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.Type: GrantFiled: May 1, 2012Date of Patent: May 3, 2016Inventors: David M. Gravett, Aniko Takacs-Cox, Philip M. Toleikis, Arpita Maiti, Leanne Embree
-
Patent number: 9125814Abstract: Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.Type: GrantFiled: April 22, 2009Date of Patent: September 8, 2015Assignee: Angiotech Pharmaceuticals, Inc.Inventors: Yuehua He, Aniko Takacs-Cox, Anthony Boey, Brent Zaluski, Roger A. Smith, Audrey A. Deschamps, Rui Avelar
-
Publication number: 20140370108Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: August 28, 2014Publication date: December 18, 2014Inventors: Nancy HARRISON, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Patent number: 8865203Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 5, 2012Date of Patent: October 21, 2014Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Patent number: 8580296Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 13, 2012Date of Patent: November 12, 2013Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Patent number: 8551515Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 13, 2012Date of Patent: October 8, 2013Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Publication number: 20130142847Abstract: Provided herein are compositions and methods to enhance the absorption of S-adenosylmethionine (SAMe) and methods of treating various disorders or diseases using non-parenteral SAMe formulations with enhanced-absorption and improved bioavailability. In certain embodiments, the enhanced bioavailability formulations provided herein may be used to treat a variety of diseases or disorders, such as for example, psychiatric disorders including, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, depressive disorders (e.g. major clinical depression) and dysthymia; as well as treating liver disorders, cancer, autoimmune disorders, inflammatory disorders, joint disorders, gastrointestinal disorders and cardiovascular disease.Type: ApplicationFiled: July 27, 2011Publication date: June 6, 2013Applicant: Methylation Sciences, Inc.Inventors: I. David MacDonald, Nancy Harrison, Aniko Takacs-Cox, Admir Purac, Almira Blazek-Welsh
-
Patent number: 8329208Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: July 28, 2010Date of Patent: December 11, 2012Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Publication number: 20120252905Abstract: Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.Type: ApplicationFiled: May 1, 2012Publication date: October 4, 2012Inventors: David M. Gravett, Aniko Takacs-Cox, Philip M. Toleikis, Arpita Maiti, Leanne Embree
-
Publication number: 20120052040Abstract: Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.Type: ApplicationFiled: March 22, 2011Publication date: March 1, 2012Applicant: Angiotech International AGInventors: William L. Hunter, Philip M. Toleikis, David M. Gravelt, Arpita Maiti, Richard T. Liggins, Aniko Takacs-Cox, Rui Avelar, Troy A.E. Loss, Dechi Guan, Kaiyue Wang
-
Publication number: 20110027360Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: July 28, 2010Publication date: February 3, 2011Applicant: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
-
Publication number: 20110027342Abstract: The invention relates to compositions and methods to enhance the absorption of S-adenosylmethionine (SAMe) and to methods of treating various disorders or diseases using non-parenteral SAMe formulations with enhanced-absorption and improved bioavailability. The enhanced bioavailability formulations may be used to treat a variety of diseases or disorders, such as for example, psychiatric disorders including, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, depressive disorders (e.g. major clinical depression) and dysthymia; as well as treating liver disorders, cancer, autoimmune disorders, inflammatory disorders, joint disorders, gastrointestinal disorders and cardiovascular disease.Type: ApplicationFiled: July 28, 2010Publication date: February 3, 2011Applicant: MSI METHYLATION SCIENCES, INC.Inventors: I. David MacDonald, Nancy Harrison, Aniko Takacs-Cox, Admir Purac, Almira Blazek-Welsh
-
Publication number: 20090324720Abstract: Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.Type: ApplicationFiled: April 22, 2009Publication date: December 31, 2009Applicant: Angiotech Pharmaceuticals, Inc.Inventors: Yuehua He, Aniko Takacs-Cox, Anthony Boey, Brent Zaluski, Roger A. Smith, Audrey A. Deschamps, Rui Avelar
-
Publication number: 20090280153Abstract: Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the devices are implanted within an animal.Type: ApplicationFiled: March 31, 2006Publication date: November 12, 2009Applicant: Angiotech International AGInventors: William L. Hunter, Philip M. Toleikis, David M. Gravett, Arpita Maiti, Richard T. Liggins, Aniko Takacs-Cox, Rui Avelar, Pierre E. Signore, Troy A. E. Loss, Anne Hutchinson, Gaye McDonald-Jones, Fara Lakhani
-
Publication number: 20090192214Abstract: Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.Type: ApplicationFiled: October 28, 2008Publication date: July 30, 2009Applicant: ANGIOTECH INTERNATIONAL AGInventors: David M. Gravett, Aniko Takacs-Cox, Philip M. Toleikis, Arpita Maiti, Leanne Embree
-
Publication number: 20080247987Abstract: The present invention describes compositions, devices, and methods for the production, use and administration of the composition having a non-thermoreversible block copolymer composition.Type: ApplicationFiled: August 4, 2006Publication date: October 9, 2008Applicant: ANGIOTECH INTERNATIONAL AGInventors: Richard T. Liggins, Aniko Takacs-Cox, David M. Gravett, Dechi Guan, Troy A.E. Loss, Muxin Liu