Abstract: Described herein are systems, methods, and software to manage the assignment of virtual machines to non-uniform memory access (NUMA) nodes of a computing environment. In one implementation, a management service identifies one or more virtual machines in a computing environment with potential NUMA resource issues. The management service further selects a virtual machine from the one or more virtual machines and determines whether a NUMA node associated with the virtual machine satisfies criteria to migrate at least one virtual machine from the NUMA node. If the criteria are satisfied, the management service migrates at least one virtual machine from the NUMA node to a second NUMA node.