Abstract: The present invention relates to compositions and methods for managing opioid tolerance and reducing opioid withdrawal. More specifically, the present invention provides for endothelin, endothelin receptors, and endothelin receptor antagonists and agonists as a means for managing G-protein activity in the context of opioid tolerance and withdrawal.

Abstract: Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.

Abstract: A burner (27) of a gas turbine engine (10) includes a cylindrical basket (60) comprising an air flow reversal region (86). The flow reversal region ends at an air inlet plane (84) of the basket. The burner also includes a flow conditioner (90) disposed in the flow reversal region transecting an air flow (80) flowing non-uniformly through the flow reversal region, the flow conditioner being effective to mitigate variation of the air flow entering the basket across the inlet plane.

Abstract: A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.

Abstract: A method for operating a burner including a burner outlet opening with at least two sectors, each sector is assigned at least one fuel nozzle, is provided. The method is characterized in that fuel is supplied separately to the fuel nozzles of different sectors. Also described is a burner which includes at least two sectors wherein each sector is assigned at least one fuel nozzle. The burner includes at least two separate fuel supply lines and a device for adjusting the fuel mass flow which flows through the respective fuel supply line. The fuel supply lines supply fuel to the fuel nozzles of different sectors. Also described is a gas turbine which is fitted with at least one burner.

Abstract: A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.

Abstract: Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.

Abstract: A pilot burner (150, 350) for a gas turbine engine delivers an inner non-swirling fuel-oxidant mixture surrounded by an outer swirling fuel-oxidant mixture, thereby providing enhanced mixing with no recirculation zone. At least one fluid-restricting inlet port (166, 366) provides an oxidant to an inner mixing passage (160, 360). The inner mixing passage (160, 360) includes a plurality of fuel outlets (168). An outer annular mixing passage (180) receives oxidant from an upstream port (181) surrounding the inner mixing passage and includes at least one swirler element (186, 386) and fuel outlets (188).

Abstract: The present invention relates, in general to treatment of pain comprising administering an alpha-2 adrenergic agonist and an endothelin antagonist, wherein administration of the agents acts as an analgesic and ameliorates pain in a subject.

Abstract: The present invention relates to compositions and methods for managing opioid tolerance and reducing opioid withdrawal. More specifically, the present invention provides for endothelin, endothelin receptors, and endothelin receptor antagonists and agonists as a means for managing G-protein activity in the context of opioid tolerance and withdrawal.

Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.

Abstract: Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ETB agonist IRL1620.

Abstract: Methods of imaging tumors are disclosed. The methods utilize an endothelin ETB receptor agonist or an endothelin ETA receptor antagonist, in combination with an imaging agent, to detect a tumor in mammals, including humans.

Abstract: Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of chemotherapeutic agent(s) (e.g., cisplatin and/or cyclophosphamide).

Abstract: A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.

Abstract: A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.

Abstract: A burner (27) of a gas turbine engine (10) includes a cylindrical basket (60) comprising an air flow reversal region (86). The flow reversal region ends at an air inlet plane (84) of the basket. The burner also includes a flow conditioner (90) disposed in the flow reversal region transecting an air flow (80) flowing non-uniformly through the flow reversal region, the flow conditioner being effective to mitigate variation of the air flow entering the basket across the inlet plane.

Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.

Abstract: Compositions and methods of preventing or treating a breast cancer are disclosed. The composition and method can utilize an endothelin B agonist and a chemotherapeutic agent as active ingredients to treat a solid tumor in mammals, including humans. Alternatively, the composition and method can utilize an endothelin B antagonist and an optional angiogenesis inhibitor to treat a solid tumor in mammals, including humans.

Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of a solid cancerous tumor are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery of a chemotherapeutic agent to a solid tumor in mammals, including humans.