Abstract: Aspects of the disclosure include telomerase inhibitor compositions formulated for subcutaneous administration. Compositions according to certain embodiments include a hyaluronidase enzyme and a telomerase inhibitor having an oligonucleotide and a lipid moiety linked to the 5? and/or 3? end of the oligonucleotide. Methods for subcutaneously administering the telomerase inhibitor compositions, such as in the treatment of a neoplasm are also described. Kits having or not having a subcutaneous injector are also provided.

Abstract: Disclosed are aspects of proactive high availability that proactively identify and predict hardware failure scenarios and migrate virtual resources to healthy hardware resources. In some aspects, a mapping that maps virtual resources to hardware resources. A plurality of hardware events are identified in association with a hardware resource. A hardware failure scenario is predicted based on a health score of a first hardware resource. A health score is determined based on the hardware events, and a fault model that indicates a level of severity of the hardware events. A particular virtual resource is migrated from the hardware resource to another hardware that has a greater health score.

Abstract: Disclosed are aspects of proactive high availability that proactively identify and predict hardware failure scenarios and migrate virtual resources to healthy hardware resources. In some aspects, a mapping that maps virtual resources to hardware resources. A plurality of hardware events are identified in association with a hardware resource. A hardware failure scenario is predicted based on a health score of a first hardware resource. A health score is determined based on the hardware events, and a fault model that indicates a level of severity of the hardware events. A particular virtual resource is migrated from the hardware resource to another hardware that has a greater health score.

Abstract: A method of managing virtual resources executing on a hardware platform that employs sensors to monitor the health of hardware resources of the hardware platform, includes filtering sensor data from the hardware platform and combining the sensor data with a fault model for the hardware platform to generate a health score, receiving an inventory that maps the virtual resources to the hardware resources of the hardware platform, receiving resource usage data describing use of the hardware resources of the hardware platform by the virtual resources, and generating resource utilization metrics from the resource usage data. The method includes receiving policy data specifying rules applicable to the inventory, determining a set of recommendations for changes to the inventory based on the health score, the resource usage data, and the policy data, and executing at least one recommendation to implement the changes to the inventory.

Abstract: A method of managing virtual resources executing on a hardware platform that employs sensors to monitor the health of hardware resources of the hardware platform, includes filtering sensor data from the hardware platform and combining the sensor data with a fault model for the hardware platform to generate a health score, receiving an inventory that maps the virtual resources to the hardware resources of the hardware platform, receiving resource usage data describing use of the hardware resources of the hardware platform by the virtual resources, and generating resource utilization metrics from the resource usage data. The method includes receiving policy data specifying rules applicable to the inventory, determining a set of recommendations for changes to the inventory based on the health score, the resource usage data, and the policy data, and executing at least one recommendation to implement the changes to the inventory.