Patents by Inventor Anil Kumar Dwivedi
Anil Kumar Dwivedi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9687480Abstract: Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion. The present invention provides chiral (2S)-1-(4-methylphenylmethyl)-5-oxo-(3S)-{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p-methylphenylmethyl)1pyroglutamate in good chiral purity.Type: GrantFiled: November 5, 2015Date of Patent: June 27, 2017Assignee: Council of Scientific & Industrial ResearchInventors: Dinesh Kumar Dikshit, Madhu Dikshit, Tanveer Irshad Siddiqui, Anil Kumar, Rabi Sankar Bhatta, Girish Kumar Jain, Manoj Kumar Barthwal, Ankita Misra, Vivek Khanna, Prem Prakash, Manish Jain, Vishal Singh, Varsha Gupta, Anil Kumar Dwivedi
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Publication number: 20160143896Abstract: Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion. The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)-{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p-methylphenylmethyl)1pyroglutamate in good chiral purity.Type: ApplicationFiled: November 5, 2015Publication date: May 26, 2016Inventors: Dinesh Kumar DIKSHIT, Madhu DIKSHIT, Tanveer Irshad SIDDIQUI, Anil KUMAR, Rabi Sankar BHATTA, Girish Kumar JAIN, Manoj Kumar BARTHWAL, Ankita MISRA, Vivek KHANNA, Prem PRAKASH, Manish JAIN, Vishal SINGH, Varsha GUPTA, Anil Kumar DWIVEDI
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Publication number: 20160009752Abstract: The present invention relates to the synthesis of pregnane-oximino-aminoalkyl-ethers and their antidiabetic and antidyslipidemic activities. More particularly, the invention relates to the synthesis of compounds of formula 3 and biological profile thereof. Further the invention relates to compounds of formula 3 and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: January 24, 2014Publication date: January 14, 2016Inventors: Prem Chandra VERMA, Jyoti GUPTA, Dharmendra Pratap SINGH, Varsha GUPTA, Hari Narayan KUSHWAHA, Anamika MISRA, Neha RAHUJA, Rohit SRIVASTAVA, Natasha JAISWAL, Ashok Kumar KHANNA, Akhilesh Kumar TAMRAKAR, Shio Kumar SINGH, Anil Kumar DWIVEDI, Arvind Kumar SRIVASTAVA, Ram PRATAP
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Patent number: 9206155Abstract: Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)—{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)—{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.Type: GrantFiled: January 12, 2012Date of Patent: December 8, 2015Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Dinesh Kumar Dikshit, Madhu Dikshit, Tanveer Irshad Siddiqui, Anil Kumar, Rabi Sankar Bhatta, Girish Kumar Jain, Manoj Kumar Barthwal, Ankita Misra, Vivek Khanna, Prem Prakash, Manish Jain, Vishal Singh, Varsha Gupta, Anil Kumar Dwivedi
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Patent number: 8686028Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substitutedType: GrantFiled: May 14, 2009Date of Patent: April 1, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Atul Goel, Amit Kumar, Sumit Chaurasia, Divya Singh, Abnish Kumar Gautam, Rashmi Pandey, Ritu Trivedi, Man Mohan Singh, Naibedya Chattopadhyay, Lakshmi Manickavasagam, Girish Kumar Jain, Anil Kumar Dwivedi
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Publication number: 20130338193Abstract: Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)-{N-[(3-t butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.Type: ApplicationFiled: January 12, 2012Publication date: December 19, 2013Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Dinesh Kumar Dikshit, Madhu Dikshit, Tanveer Irshad Siddiqui, Anil Kumar, Rabi Sankar Bhata, Girish Kumar Jain, Manoj Kumar Barthwal, Ankita Misra, Vivek Khanna, Prem Prakash, Manish Jain, Vishal Singh, Varsha Gupta, Anil Kumar Dwivedi
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Patent number: 8496964Abstract: The present invention relates to a microcapsule for controlled release of flavanoid compound and a process for preparation thereof. The microcapsule comprising a core particle consisting of a calcium salt, Pluronic F68 [poly (ethylene oxide-co-polypropylene oxide), block poly oxyethylene-polypropylene block copolymer], loaded with a flavanoid compound, the resulting core particle having a plurality of alternate layers of cationic and anionic polyelectrolytes adsorbed thereon and an outer layer formed by a bile salt, wherein the flavanoid is ranging between 10 to 96% by weight.Type: GrantFiled: February 26, 2010Date of Patent: July 30, 2013Assignee: Council of Scientific & Industrial ResearchInventors: Prabhat Ranjan Mishra, Ritu Trivedi, Girish Kumar Gupta, Avinash Kumar, Varsha Gupta, Srikanta Kumar Rath, Kamini Srivastava, Naibedya Chattopadhyay, Anil Kumar Dwivedi
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Publication number: 20120003273Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substitutedType: ApplicationFiled: May 14, 2009Publication date: January 5, 2012Inventors: Atul Goel, Amit Kumar, Sumit Chaurasia, Divya Singh, Abnish Kumar Gautam, Rashmi Pandey, Ritu Trivedi, Man Mohan Singh, Naibedya Chattopadhyay, Lakshmi Manickavasagam, Girish Kumar Jain, Anil Kumar Dwivedi
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Publication number: 20110305754Abstract: The present invention relates to a microcapsule for controlled release of flavanoid compound and a process for preparation thereof. The microcapsule comprising a core particle consisting of a calcium salt, Pluronic F68 [poly (ethylene oxide-co-polypropylene co-polypropylene oxide), block poly oxyethylene-polypropylene block copolymer], loaded with a flavanoid compound, the resulting core particle having a plurality of alternate layers of cationic and anionic polyelectrolytes adsorbed thereon and an outer layer formed by a bile salt, wherein the flavanoid is ranging between 10 to 96% by weight.Type: ApplicationFiled: February 26, 2010Publication date: December 15, 2011Inventors: Prabhat Ranjan Mishra, Ritu Trivedi, Girish Kumar Gupta, Avinash Kumar, Varsha Gupta, Srikanta Kumar Rath, Kamini Srivastava, Naibedya Chattopadhyay, Anil Kumar Dwivedi
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Publication number: 20110077294Abstract: The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R? is selected from a group consisting of t-butyl amine, n-butylamine, iso-butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)-piperazin-1-ylamine, and 3,4-dimethoxy phenethyl amine; wherein R1, R2 and R3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R4, R5 and R6 are selected from the group consisting of Oil, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.Type: ApplicationFiled: August 2, 2007Publication date: March 31, 2011Inventors: Ram Pratap, Himanshu Singh, Alok Kumar Verma, Amar Bahadur Singh, Priti Priti Tiwari Tiwari, Mukesh Srivastava, Arvind Kumar Srivastava, Anil Kumar Dwivedi, Satyawan Singh, Pratima Pnahma Svivastva Srivastava, Shio Kumar Singh, Chandishwar Nath, Ram Raghubir
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Patent number: 7404962Abstract: A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.Type: GrantFiled: August 30, 2000Date of Patent: July 29, 2008Assignees: Nicholas Piramal India Limited, Council of Scientific and Industrial ResearchInventors: Francis Joseph Pinto, Swati Ajay Piramal, Ram Pratap, Amiya Prasad Bhaduri, Harsh Pati Thapliyal, Sunil Kumar Puri, Guru Prasad Dutta, Anil Kumar Dwivedi, Satyawan Singh, Pratima Srivastava, Vikash Chandra Pandey, Sudhir Srivastava, Shio Kumar Singh, Ram Chandra Gupta, Jagdishwar Sahai Srivastava, Omkar Prasad Asthana
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Patent number: 7183291Abstract: The present invention a novel use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and controlling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.Type: GrantFiled: May 21, 1999Date of Patent: February 27, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Ram Pratap, Amiya Prasad Bhaduri, Harsh Pati Thapliyal, Sunil Kumar Puri, Guru Prasad Dutta, Anil Kumar Dwivedi, Satyawan Singh, Pratima Srivastava, Vikash Chandra Pandey, Sudhir Srivastava, Shio Kumar Singh, Ram Chandra Gupta, Jagdishwar Sahai Srivastava, Omkar Prasad Asthana
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Patent number: 6740639Abstract: The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin derivatives, the complexes being better soluble in water and having improved biopharmaceutical properties such as lesser toxicity, better analgesic action and non-addiction properties.Type: GrantFiled: March 29, 2000Date of Patent: May 25, 2004Assignee: Council of Scientific & Industrial ResearchInventors: Anil Kumar Dwivedi, Madhu Khanna, Wahajul Haq, Ram Raghubir, Sudhir Srivastava, Puvvada Sri Ramchandra Murthy, Onkar Prasad Asthana, Jagdishwar Sahay Srivastava, Satyawan Singh
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Publication number: 20030199697Abstract: The present invention a novel use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and contolling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.Type: ApplicationFiled: May 21, 1999Publication date: October 23, 2003Inventors: RAM PRATAP, AMIYA PRASAD BHADURI, HARSH PATI THAPLIYAL, SUNIL KUMAR PURI, GURU PRASAD DUTTA, ANIL KUMAR DWIVEDI, SATYAWAN SINGH, PRATIMA SRIVASTAVA, VIKASH CHANDRA PANDEY, SUDHIR SRIVASTAVA, SHIO KUMAR SINGH, RAM CHANDRA GUPTA, JAGDISHWAR SAHAI SRIVASTAVA, OMKAR PRASAD ASTHANA
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Patent number: 6326023Abstract: The present invention relates to a synergistic formulation comprising pharmaceutically effective amount of &agr;/&bgr; arteether and a neutralized refined vegetable oil suitable for administration by rectal route, method for the treatment of cerebral and comatose malaria and process for the preparation of the said formulation.Type: GrantFiled: March 28, 2000Date of Patent: December 4, 2001Assignee: Council of Scientific & Industrial ResearchInventors: Guru Prakash Dutta, Dharam Chand Jain, Ranjendra Singh Bhakuni, Sudhanshu Saxena, Sangeeta Dhawan, Suman Preet Singh Khanuja, Sushil Kumar, Renu Tripathi, Aseem Umesh, Nuzhat Kamal, Anil Kumar Dwivedi, Satyawan Singh