Abstract: Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective .alpha..sub.1A adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.

Abstract: The invention relates to a process for the synthesis of 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes used as potential therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders, having general formula 1 ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; a process of preparing said compounds and a method of treating hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders.

Abstract: Method for homopolymerization of polyorganosiloxane macromonomers having acryloxy or methacryloxy groups. A miniemulsion of a methacryloxy functional polydimethylsiloxane macromonomer was prepared by mixing the macromonomer with a surfactant(s), and subjecting it to a high shear device. The macromonomer was polymerized in the miniemulsion by using a free radical initiator at high temperature. The amount of unreacted macromonomer is very low.

Abstract: This invention relates to the preparation of an addition curable composition which when cured has increased thermal stability. The addition curable composition comprises an organic polymer having on average at least 1.4 alkenyl groups per molecule, a crosslinker having on average at least 2 hydrosilyl groups per molecule, a platinum group metal-containing catalyst and a benzotriazole derivative stabilizer.

Abstract: The present invention relates to a method for preparing a polyisobutylene-siloxane block copolymer, said method comprising:(I) lithiating(A) a polyisobutylene having one or two terminal silanol groups with(B) an organolithium compound;(II) reacting the silanolate-functional polyisobutylene obtained in step (I) with(C) a hexaorganocyclotrisiloxane; and(III) capping the siloxanotate-functional block copolymer obtained in step (II) with a compound selected from(D) a silane having at least one hydrolyzable group or(E) an acid.

Abstract: Method of making copolymers of (i) an acrylic or methacrylic-functional polyisobutylene macromonomer, (ii) a polydiorganosiloxane macromonomer, and optionally (iii) a radical polymerizable monomer such as an alkyl acrylate or alkyl methacrylate. The copolymers are prepared by copolymerizing the monomers in a miniemulsion using a free radical initiator at high temperature. In the method, the monomers are mixed with a surfactant(s) and optionally a cosurfactant(s), and subjected to high shear.

Abstract: This invention relates to the preparation of an addition curable composition which when cured has increased resistance to degradation by ultraviolet light. The addition curable composition comprises an organic polymer having on average at least 1.4 alkenyl groups per molecule, a crosslinker having on average at least 2 hydrosilyl groups per molecule, a platinum group metal-containing catalyst and a benzotriazole derivative stabilizer.

Abstract: The present invention relates to a method for preparing an acrylic-functional polyisobutylene polymer or copolymer, said method comprising reacting a polyisobutylene polymer or copolymer which contains at least one carbon-bonded silanol group in its molecule with a silane having both an acrylic-containing group and a silicon-bonded hydrolyzable group in its molecule.