Abstract: The present disclosure relates to crystalline forms of venetoclax and process for their preparation. The present disclosure also relates to process for preparation of amorphous venetoclax.

Abstract: The present invention is related to a novel gastroretentive swellable oral dosage form for sustained or delayed release of bergenin, a active constituent of Bergenia ciliata extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract of bergenin-rich Bergenia ciliata with polymers has resulted in a sustained release of extract in the stomach over a period of 16-24 hrs. The said formulations are useful for the treatment of inflammatory diseases.

Abstract: The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.

Abstract: 1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: A separating and cleaning mechanism for an agricultural combine may include: a return pan. The return pan includes a textured floor, two augers, and two motors coupled to the two augers, respectively, to selectively drive the motors in rotation independently. The textured floor may oscillate in a fore-and-aft direction to move grain toward the two augers.

Abstract: The present invention relates to a novel process for the preparation of lifitegrast of Formula I. The present invention further provides a novel process for the purification of lifitegrast of Formula I.

Abstract: Systems and methods for detecting and representing traffic maneuvers are provided. The method includes receiving traffic information for a neighbor traffic. The method may use the neighbor traffic information to calculate a volume around the neighbor traffic, defined by min max thresholds related to the traffic information. The traffic information is monitored until the default time elapses, to thereby determine a delta latitudinal position, a delta longitudinal position, a delta altitude, a delta pitch, and a delta roll, of the neighbor traffic during the default time; and a traffic maneuver is identified upon the occurrence of one or more of (i) the delta latitudinal position exceeded the maximum latitudinal threshold, (ii) the delta longitudinal position exceeded the maximum longitudinal threshold, and (iii) the delta altitude exceeded the magnitude of the maximum altitude threshold. An enhanced symbolic indicator of the traffic maneuver is rendered on a map image.

Abstract: A coating for a diamond table of a cutting element is described. The coating is employed to fill a plurality of voids left by the manufacturing process that compromise the integrity of the cutting element and the associated downhole tooling. The coating may comprise diamond nanoparticles in a metal matrix and may be used with or without a binder layer applied directly to the diamond table, the coating may alternatively be a pure diamond film coating, and may be employed to fill voids left by the manufacturing process.

Abstract: A method and apparatus for acquiring an image is provided herein. During operation a determination is made that a user is intending to tag an object through pointing a finger at the object. In response, a pre-buffer is accessed, and an image of the object is selected from the pre-buffer that is absent the user's hand. Once the image has been selected, the image can be forwarded to other users.

Abstract: Disclosed is a pharmaceutical composition for obesity inhibition for photodynamically inhibiting obesity, containing trisodium Chlorin e6 as an active ingredient.

Abstract: A method of storing or searching data files on a plurality of cloud-based storage systems includes detecting an event on the electronic device indicative of storing at least one data file on a cloud-based storage, analyzing the at least one data file in response to detecting the event to extract a plurality of elements, mapping the plurality of elements to one or more rules stored in a memory of the electronic device, selecting at least one cloud-based storage for storing the at least one data file, and storing information corresponding to the at least one data file in the memory upon storing the at least one data file onto the selected at least one cloud-based storage for searching the at least one data file.

Abstract: A progressive pool controller within a gaming environment can have programmable contents thereof retrieved or changed without need for user interaction with the controller other than inserting a dynamically-linkable and reprogrammable storage device (e.g., a USB flash drive) into an I/O receptacle of the controller. The controller has a service automatically repeatedly executing therein, checking for insertion of the storage device, checking for recognizable commands within the inserted storage device after it is inserted, executing command following programs for the recognizable commands, saving output results of the executed programs into the inserted storage device and signaling that the storage device should be removed from the I/O receptacle upon completed execution of all the command following programs. Contents of the storage device remain encrypted when in transit and are exposed within secured confines of the controller.

Abstract: The configuring of an electronic gaming machine (EGM) to participate in pools managed by a progressive pools managing controller (PPMC) can be complex. The process is simplified in accordance with the present disclosure by automatically transmitting from an EGM and to its corresponding PPMC, an auto-configuration request identifying the EGM and a predetermined wagering game supported by the EGM; responsively receiving from the PPMC and within the EGM a listing of one or more progressive pools that are managed by the PPMC and that have been determined within the PPMC to be progressive pools that the predetermined wagering game of the requesting EGM is qualified to or required to participate in; and causing the predetermined wagering game of the EGM to begin participating in at least one of the listed progressive pools.

Abstract: A package for holding pharmaceutical containers on a filling line includes: a transport and packaging container having a plurality of connected sidewalls, a base, an upper edge opposite the base, and a step defining a step height that is constant relative to the upper edge and less than an overall height defined between the upper edge and the base; and a holder placed in the transport and packaging container and having a plurality of holder openings formed therein. The holder is supported on the step and configured to hold a container in each of the holder openings so the held containers are suspended within the transport and packaging container. The step height is constant and independent of at least one of a shape, a type, or a size of each of the held containers.

Abstract: This disclosure describes techniques for resolving discrepancies that occur to interrelated computing resources from computing resource drift. Users may describe computing resources in an infrastructure template. However, computing resource drift occurs when “out-of-band” modifications are made to the computing resources and are not reflected in the infrastructure template. To resolve discrepancies between the infrastructure template and the out-of-band modifications to the computing resources, a notification may be output to a user account associated with the computing resources detailing the differences. An updated infrastructure template may be received that resolves the differences, such as by including configuration settings that reflect a current state of the computing resources. The computing resources may then execute a workflow using the updated template, such that the workflow is executed on all of the computing resources in a current state.

Abstract: The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709:

Abstract: One example system includes a biosensor applicator having a housing defining a cavity configured to receive and physically couple to a biosensor device, and to apply the biosensor device to a wearer; an applicator coil antenna oriented around a first axis; and a biosensor device including a biosensor coil antenna; a first wireless transceiver electrically coupled to the biosensor coil antenna; a Bluetooth antenna; and a second wireless transceiver coupled to the Bluetooth antenna; wherein the biosensor device is physically coupled to the biosensor applicator and positioned at least partially within the cavity; and wherein the applicator coil antenna is configured to wirelessly receive electromagnetic (“EM”) energy from a remote coil antenna and wirelessly provide at least a first portion of the received EM energy to the biosensor coil antenna.

Abstract: Techniques are provided for an object file system for an object store. Data, maintained by a computing device, is stored into slots of an object. The data within the slots of the object is represented as a data structure comprising a plurality of nodes comprising cloud block numbers used to identify the object and particular slots of the object. A mapping metafile is maintained to map block numbers used to store the data by the computing device to cloud block numbers of nodes representing portion of the data stored within slots of the object. The object is stored into the object store, and the mapping metafile and the data structure are used to provide access through the object file system to portions of data within the object.

Abstract: Techniques are provided for an object file system for an object store. Data, maintained by a computing device, is stored into slots of an object. The data within the slots of the object is represented as a data structure comprising a plurality of nodes comprising cloud block numbers used to identify the object and particular slots of the object. A mapping metafile is maintained to map block numbers used to store the data by the computing device to cloud block numbers of nodes representing portion of the data stored within slots of the object. The object is stored into the object store, and the mapping metafile and the data structure are used to provide access through the object file system to portions of data within the object.

Abstract: Systems and methods in accordance with embodiments of the invention can automatically track the creation of documents, such as source code files and unit tests, along with the development of those documents. The document creation and development workflow can be automatically validated against a defined set of standards to ensure that the documents are properly created. The review of the documents can also be automatically validated to ensure that the review process is properly completed. A variety of metrics can be generated regarding errors and issues identified during the validation processes. These metrics can be used to identify common issues, automatically generate proactive suggestions to avoid issues during document creation and testing, and/or generate developer profiles indicating the performance of particular developers.