Patents by Inventor Anil Modak

Anil Modak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2' Deoxy-2'-Alkylnucleotide Containing Nucleic Acid
    Publication number: 20090221807
    Abstract: 2?-deoxy-2?-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Application
    Filed: September 8, 2008
    Publication date: September 3, 2009
    Applicant: SIRNA THERAPEUTICS INC.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • Method for Monitoring Patient or Subject Compliance with Medical Prescriptions, and Formulation for Use in the Method
    Publication number: 20090041662
    Abstract: The present invention provides a highly accurate method for monitoring patient or subject compliance with a medication prescription by collecting a sample of the exhaled air. The method of the present invention is easy and little burdens the patient or subject. The method comprises the steps of: (i) prescribing a patient or subject ingestion of at least one biologically active agent and at least one carbon isotope-labeled lipid, (ii) obtaining a sample of the patient's or subject's exhaled air, (iii) measuring the ratio of the carbon isotope-labeled CO2 relative to 12CO2 in the sample; and (iv) confirming the ingestion of the prescribed biologically active agent based on the ratio of the carbon isotope-labeled CO2 relative to 12CO2.
    Type: Application
    Filed: February 22, 2006
    Publication date: February 12, 2009
    Inventors: Irie Yasuo, Anil Modak, Tadashi Mukai
  • Method and composition to evaluate cytochrome P450 2D6 isoenzyme activity using a breath test
    Publication number: 20070026480
    Abstract: The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.
    Type: Application
    Filed: April 14, 2006
    Publication date: February 1, 2007
    Inventors: Anil Modak, Yasuo Irie, Yasuhisa Kurogi
  • Method and composition to individualize Levodopa/Carbidopa therapy using a breath test
    Publication number: 20070003481
    Abstract: The present invention relates, generally to a method of determining and assessing L-3,4-dihydroxyphenylalanine (a.k.a., Levodopa; L-dopa; or LD) metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by the subject upon intravenous or oral administration of a 13C-labeled substrate, such as levodopa. The present invention is useful as an in vivo phenotype assay for individualizing LD/Carbidopa(CD) therapy in Parkinsons disease patients by optimizing the dose and timing of the dose of dopamine decarboxylase (DDC) inhibitor like CD for systemic suppression of dopamine metabolism by evaluating DDC enzyme activity using the metabolite 13CO2 in expired breath.
    Type: Application
    Filed: June 30, 2006
    Publication date: January 4, 2007
    Inventors: Anil Modak, Yasuhisa Kurogi
  • Method for monitoring patient or subject compliance with medical prescriptions, and formulation for use in the method
    Publication number: 20060188444
    Abstract: The present invention provides a highly accurate method for monitoring patient or subject compliance with a medication prescription by collecting a sample of the exhaled air. The method of the present invention is easy and little burdens the patient or subject. The method comprises the steps of: (i) prescribing a patient or subject ingestion of at least one biologically active agent and at least one carbon isotope-labeled lipid, (ii) obtaining a sample of the patient's or subject's exhaled air, (iii) measuring the ratio of the carbon isotope-labeled CO2 relative to 12CO2 in the sample; and (iv) confirming the ingestion of the prescribed biologically active agent based on the ratio of the carbon isotope-labeled CO2 relative to 12CO2.
    Type: Application
    Filed: February 23, 2005
    Publication date: August 24, 2006
    Inventors: Yasuo Irie, Anil Modak, Tadashi Mukai
  • 2'-deoxy-2'alkylnucleotide containing nucleic acid
    Publication number: 20060142557
    Abstract: 2?-deoxy-2?-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Application
    Filed: February 27, 2006
    Publication date: June 29, 2006
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • 2'-deoxy-2'-alkylnucleotide containing nucleic acid
    Publication number: 20020197684
    Abstract: 2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Application
    Filed: March 21, 2002
    Publication date: December 26, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • 2?-deoxy-2?-alkylnucleotide containing nucleic acid
    Patent number: 6365374
    Abstract: 2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: April 2, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • 2'-deoxy-2'-alkylnucleotide containing nucleic acid
    Patent number: 5985621
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: November 16, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • 2'-deoxy-2'alkylnucleotide containing nucleic acid
    Patent number: 5639647
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules are disclosed.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: June 17, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • 2'deoxy-2'-alkylnucleotide containing nucleic acid
    Patent number: 5627053
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: May 6, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak