Patents by Inventor Anil Rajaram Oroskar
Anil Rajaram Oroskar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11795130Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: GrantFiled: August 3, 2021Date of Patent: October 24, 2023Assignee: Kazmira LLCInventors: Anil Rajaram Oroskar, David W. House, Praneeth Dayanthe Edirisinghe, Asha Anil Oroskar, Faridedin Adel, Xinjie Chen, Gautham Anil Oroskar, Kunal Gulati
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Publication number: 20220297030Abstract: A method of removing THC and THCA from a non-decarboxylated hemp extract, the non-decarboxylated hemp extract including THC and THCA and at least one cannabinoid is provided. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.1 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: June 1, 2022Publication date: September 22, 2022Applicant: Kazmira LLCInventors: Anil Rajaram Oroskar, Kunal Gulati, David House, Gautham Oroskar, Feng Peng, Michelle Chen, Faridedin Adel, Pulak Sharma, Justin Fulford
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Publication number: 20220185787Abstract: A method of removing THC and/or THCA from a mixture, the mixture including THC and/or THCA and at least one cannabinoid is provided. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.3 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: December 10, 2021Publication date: June 16, 2022Applicant: Orochem Technologies Inc.Inventors: Anil Rajaram Oroskar, Kunal Gulati, David House, Gautham Oroskar, Feng Peng, Michelle Chen, Faridedin Adel, Pulak Sharma, Justin Fulford
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Publication number: 20220177806Abstract: Embodiments of a method of purifying a lysophosphatidylcholine (e.g., LPC-DHA and/or LPC-EPA) from a composition containing the lysophosphatidylcholine and at least one impurity, e.g., from phospholipids, free fatty acids, triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), glycerol, sterols, tocopherols, vitamin A, flavonoids, and minerals can use a continuous simulated moving bed process, a batch column chromatography method, or a single column to provide a purified composition of the lysophosphatidylcholine. The purified lysophosphatidylcholine (e.g., LPC-DHA and/or LPC-EPA) products can be used in various pharmaceutical and nutraceutical applications, e.g., for treating and/or preventing a neurological disease or disorder.Type: ApplicationFiled: December 8, 2021Publication date: June 9, 2022Applicant: Orochem Technologies Inc.Inventors: Anil Rajaram OROSKAR, Babu Siddegowda ANTHARAVALLY, Asha Anil OROSKAR
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Patent number: 11213558Abstract: The present invention relates generally to improved methods for the extraction and isolation of cannabinoids from hemp. More particularly, the present invention relates to a series of extraction and isolation processes employed to selectively enhance recovery of non-psychoactive cannabinoids and the like, from cannabis materials and extracts, while removing undesirable naturally occurring components that may be present including colorants, carbohydrates, sugars and waxes, and the like, as well as contaminants that may be present in source materials including bactericides, fungicides, insecticides, plant growth regulators, environmental pollutants, and processing aids, and the like. The present invention further relates to an isolate obtained using a series of extraction and isolation processes that has extremely high cannabinoid content present in a stable, flowable liquid form that is essentially free of detectable levels of psychoactive cannabinol components.Type: GrantFiled: May 16, 2018Date of Patent: January 4, 2022Assignee: Orochem Technologies, Inc.Inventors: Anil Rajaram Oroskar, David W. House, Kashif Shan, Rajesh Kumar Gupta
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Publication number: 20210363083Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: August 3, 2021Publication date: November 25, 2021Applicant: Orochem Technologies Inc.Inventors: Anil Rajaram OROSKAR, David W. HOUSE, Praneeth Dayanthe EDIRISINGHE, Asha Anil OROSKAR, Faridedin ADEL, Xinjie CHEN, Gautham Anil OROSKAR, Kunal GULATI
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Patent number: 11078145Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: GrantFiled: September 3, 2020Date of Patent: August 3, 2021Assignee: Orochem Technologies Inc.Inventors: Anil Rajaram Oroskar, David W. House, Praneeth Dayanthe Edirisinghe, Asha Anil Oroskar, Faridedin Adel, Xinjie Chen, Gautham Anil Oroskar, Kunal Gulati
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Publication number: 20210186893Abstract: Provided is a composition comprising: a polysorbate, vitamin E TPGS, a cannabinoid, and an antioxidant. Also provided is a use of the composition for oral consumption and/or topical application and a method of making the composition.Type: ApplicationFiled: December 7, 2020Publication date: June 24, 2021Applicant: Orochem Technologies Inc.Inventors: Babu Siddegowda Antharavally, Anil Rajaram OROSKAR, Pulak SHARMA, Asha Anil OROSKAR
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Publication number: 20210038558Abstract: Provided is a composition comprising: (a) a polysorbate, (b) vitamin E TPGS, and (c) a cannabinoid. Also provided is a use of the composition for oral consumption and a method of making the composition.Type: ApplicationFiled: August 7, 2019Publication date: February 11, 2021Applicant: Orochem Technologies Inc.Inventors: Babu Siddegowda Antharavally, Anil Rajaram OROSKAR, Pulak SHARMA, Asha Anil OROSKAR
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Publication number: 20200399194Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Applicant: Orochem Technologies Inc.Inventors: Anil Rajaram OROSKAR, David W. HOUSE, Praneeth Dayanthe EDIRISINGHE, Asha Anil OROSKAR, Faridedin ADEL, Xinjie CHEN, Gautham Anil OROSKAR
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Patent number: 10843991Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: GrantFiled: August 27, 2018Date of Patent: November 24, 2020Assignee: Orochem Technologies Inc.Inventors: Anil Rajaram Oroskar, David W. House, Praneeth Dayanthe Edirisinghe, Asha Anil Oroskar, Faridedin Adel, Xinjie Chen, Gautham Anil Oroskar, Kunal Gulati
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Patent number: 10604464Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp and cannabis leaves can use a continuous simulated moving bed process and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: GrantFiled: July 5, 2018Date of Patent: March 31, 2020Assignee: Orochem Technologies, Inc.Inventors: Anil Rajaram Oroskar, David W. House, Praneeth Dayanthe Edirisinghe, Asha Anil Oroskar, Faridedin Adel, Xinjie Chen, Gautham Anil Oroskar
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Publication number: 20200016091Abstract: Provided is a composition for oral consumption comprising (a) methylated-?-cyclodextrin and/or hydroxypropylated-?-cyclodextrin, (b) cannabidiol, and (c) water. Also provided is a method of making a composition for oral consumption comprising (a) methylated-?-cyclodextrin and/or hydroxypropylated-?-cyclodextrin, (b) cannabidiol, and (c) water.Type: ApplicationFiled: July 16, 2018Publication date: January 16, 2020Applicant: Orochem Technologies, Inc.Inventors: Anantha Krishna MALLIA, David W. HOUSE, Anil Rajaram OROSKAR, Asha Anil OROSKAR
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Patent number: 10189762Abstract: Disclosed is a method for purification and separation of cannabinoids, specifically cannabidiol and tetrahydrocannabinol, from the dried hemp and cannabis leaves using a combination of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, a continuous simulated moving bed process, polishing, and crystallization to separate cannabinoids from tetrahydrocannabinol and to provide phytocannabinoid rich oil and cannabidiol isolate. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: GrantFiled: July 7, 2017Date of Patent: January 29, 2019Assignee: Orochem Technologies, Inc.Inventors: Anil Rajaram Oroskar, David W. House, Praneeth Dayanthe Edirisinghe, Asha Anil Oroskar, Faridedin Adel, Xinjie Chen, Gautham Anil Oroskar
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Publication number: 20190010106Abstract: Disclosed is a method for purification and separation of cannabinoids, specifically cannabidiol and tetrahydrocannabinol, from the dried hemp and cannabis leaves using a combination of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, a continuous simulated moving bed process, polishing, and crystallization to separate cannabinoids from tetrahydrocannabinol and to provide phytocannabinoid rich oil and cannabidiol isolate. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: July 7, 2017Publication date: January 10, 2019Inventors: ANIL RAJARAM OROSKAR, DAVID W. HOUSE, PRANEETH DAYANTHE EDIRISINGHE, ASHA ANIL OROSKAR, FARIDEDIN ADEL, XINJIE CHEN, GAUTHAM ANIL OROSKAR
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Publication number: 20190010107Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp and cannabis leaves can use a continuous simulated moving bed process and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: July 5, 2018Publication date: January 10, 2019Applicant: Orochem Technologies, Inc.Inventors: Anil Rajaram OROSKAR, David W. HOUSE, Praneeth Dayanthe EDIRISINGHE, Asha Anil OROSKAR, Faridedin ADEL, Xinjie CHEN, Gautham Anil Oroskar
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Publication number: 20190010110Abstract: A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.Type: ApplicationFiled: August 27, 2018Publication date: January 10, 2019Applicant: Orochem Technologies, Inc.Inventors: Anil Rajaram OROSKAR, David W. HOUSE, Praneeth Dayanthe EDIRISINGHE, Asha Anil OROSKAR, Faridedin ADEL, Xinjie CHEN, Gautham Anil OROSKAR
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Patent number: 8807164Abstract: The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.Type: GrantFiled: August 30, 2007Date of Patent: August 19, 2014Assignee: Semba Biosciences, Inc.Inventors: Joerg Werner Baier, Robert Charles Mierendorf, Anthony Charles Grabski, Andrew Paul Wilke, Anil Rajaram Oroskar
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Patent number: 7790040Abstract: The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.Type: GrantFiled: August 30, 2007Date of Patent: September 7, 2010Assignee: Semba Biosciences, Inc.Inventors: Robert Charles Mierendorf, Herbert Edmund Paaren, Anthony Charles Grabski, Andrew Wilke, Joerg Werner Baier, Anil Rajaram Oroskar
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Patent number: 7544293Abstract: A unique valve assembly for simulated bed moving chromatography employs a combination of pressure compatible sealable materials that permit minimal frictional interaction between moving parts, ensures alignment of parts, and provides a method for conducting SMB countercurrent chromatography on a small scale, in which purity and separation efficiency are enhanced. Machine designs are disclosed which embody the SMB concepts. Finally, a quick disconnect connector and adaptor is provided for mounting chromatographic columns in an SMB device. Demonstration of this system in a fructose-glucose isomer separation with purity-recovery trade-off for this device is also presented.Type: GrantFiled: September 26, 2005Date of Patent: June 9, 2009Assignee: SEMBA Inc.Inventors: Anil Rajaram Oroskar, Saurabh Paresh Parikh, Asha Anil Oroskar, Kenneth U. Johnson, Anthony Joseph Escarcega