Abstract: Generally, this disclosure provides devices, methods and computer readable media for packet processing with reduced latency. The device may include a data queue to store data descriptors associated with data packets, the data packets to be transferred between a network and a driver circuit. The device may also include an interrupt generation circuit to generate an interrupt to the driver circuit. The interrupt may be generated in response to a combination of an expiration of a delay timer and a non-empty condition of the data queue. The device may further include an interrupt delay register to enable the driver circuit to reset the delay timer, the reset postponing the interrupt generation.

Abstract: Devices and techniques for reorder resilient transport are described herein. A device may store data packets in sequential positions of a flow queue in an order in which the data packets were received. The device may retrieve a first data packet from a first sequential position and a second data packet from a second sequential position that is next in sequence to the first sequential position in the flow queue. The device may store the first data packet and the second data packet in a buffer and refrain from providing the first data packet and the second data packet to upper layer circuitry if the packet order information for the first data packet and the second data packet indicate that the first data packet and the second data packet were received out of order. Other embodiments are also described.

Abstract: Technologies for accelerating non-uniform network input/output accesses include a multi-home network interface controller (NIC) of a network computing device communicatively coupled to a plurality of non-uniform memory access (NUMA) nodes, each of which include an allocated number of processor cores of a physical processor package and an allocated portion of a main memory directly linked to the physical processor package. The multi-home NIC includes a logical switch communicatively coupled to a plurality of logical NICs, each of which is communicatively coupled to a corresponding NUMA node. The multi-home NIC is configured to facilitate the ingress and egress of network packets by determining a logical path for each network packet received at the multi-home NIC based on a relationship between one of the NUMA nodes and/or a logical NIC (e.g., to forward the network packet from the multi-home NIC) coupled to the one of the NUMA nodes. Other embodiments are described herein.

Abstract: This disclosure relates to: (a) compounds and salts of formula (I), formula (II), formula (III), and formula (IV), that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract: Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.

Abstract: An apparatus and method are described for a triggered prefetch operation. For example, one embodiment of a processor comprises: a first core comprising a first cache to store a first set of cache lines; a second core comprising a second cache to store a second set of cache lines; a cache management circuit to maintain coherency between one or more cache lines in the first cache and the second cache, the cache management circuit to allocate a lock on a first cache line to the first cache; a prefetch circuit comprising a prefetch request buffer to store a plurality of prefetch request entries including a first prefetch request entry associated with the first cache line, the prefetch circuit to cause the first cache line to be prefetched to the second cache in response to an invalidate command detected for the first cache line.

Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

Abstract: In one embodiment, a method is provided. The method of this embodiment provides storing a packet header at a set of at least one page of memory allocated to storing packet headers, and storing the packet header and a packet payload at a location not in the set of at least one page of memory allocated to storing packet headers.

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Abstract: In one embodiment, a method is provided. The method of this embodiment provides storing a packet header at a set of at least one page of memory allocated to storing packet headers, and storing the packet header and a packet payload at a location not in the set of at least one page of memory allocated to storing packet headers.

Abstract: Devices and techniques for reorder resilient transport are described herein. A device may store data packets in sequential positions of a flow queue in an order in which the data packets were received. The device may retrieve a first data packet from a first sequential position and a second data packet from a second sequential position that is next in sequence to the first sequential position in the flow queue. The device may store the first data packet and the second data packet in a buffer and refrain from providing the first data packet and the second data packet to upper layer circuitry if the packet order information for the first data packet and the second data packet indicate that the first data packet and the second data packet were received out of order. Other embodiments are also described.

Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

Abstract: A device is provided with two or more uplink ports to connect the device via two or more links to one or more sockets, where each of the sockets includes one or more processing cores, and each of the two or more links is compliant with a particular interconnect protocol. The device further includes I/O logic to identify data to be sent to the one or more processing cores for processing, determine an affinity attribute associated with the data, and determine which of the two or more links to use to send the data to the one or more processing cores based on the affinity attribute.

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Abstract: Technologies for accelerating non-uniform network input/output accesses include a multi-home network interface controller (NIC) of a network computing device communicatively coupled to a plurality of non-uniform memory access (NUMA) nodes, each of which include an allocated number of processor cores of a physical processor package and an allocated portion of a main memory directly linked to the physical processor package. The multi-home NIC includes a logical switch communicatively coupled to a plurality of logical NICs, each of which is communicatively coupled to a corresponding NUMA node. The multi-home NIC is configured to facilitate the ingress and egress of network packets by determining a logical path for each network packet received at the multi-home NIC based on a relationship between one of the NUMA nodes and/or a logical NIC (e.g., to forward the network packet from the multi-home NIC) coupled to the one of the NUMA nodes. Other embodiments are described herein.

Abstract: An apparatus and method are described for a triggered prefetch operation. For example, one embodiment of a processor comprises: a first core comprising a first cache to store a first set of cache lines; a second core comprising a second cache to store a second set of cache lines; a cache management circuit to maintain coherency between one or more cache lines in the first cache and the second cache, the cache management circuit to allocate a lock on a first cache line to the first cache; a prefetch circuit comprising a prefetch request buffer to store a plurality of prefetch request entries including a first prefetch request entry associated with the first cache line, the prefetch circuit to cause the first cache line to be prefetched to the second cache in response to an invalidate command detected for the first cache line.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: One embodiment provides a method for enabling class-based credit flow control for a network node in communication with a link partner using an Ethernet communications protocol. The method includes receiving a control frame from the link partner. The control frame includes at least one field for specifying credit for at least one traffic class and the credit is based on available space in a receive buffer associated with the at least one traffic class. The method further includes sending data packets to the link partner based on the credit, the data packets associated with the at least one traffic class.