Patents by Inventor Anilkumar Harapanahalli Achyuta
Anilkumar Harapanahalli Achyuta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11213687Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.Type: GrantFiled: March 23, 2016Date of Patent: January 4, 2022Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Jonathan Bernstein, Daniel Freeman, Reed Irion, Brett Ingersoll, Amy Duwel, Andrew Czarnecki, Brian Daniels, Anilkumar Harapanahalli Achyuta, Bryan McLaughlin
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Patent number: 10913925Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: GrantFiled: November 23, 2016Date of Patent: February 9, 2021Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of TechnologyInventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Patent number: 10039923Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.Type: GrantFiled: February 3, 2016Date of Patent: August 7, 2018Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Jonathan Bernstein, Daniel Freeman, Reed Irion, Brett Ingersoll, Amy Duwel, Andrew Czarnecki, Brian Daniels, Anilkumar Harapanahalli Achyuta, Bryan McLaughlin
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Publication number: 20170216607Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.Type: ApplicationFiled: March 23, 2016Publication date: August 3, 2017Inventors: Jonathan Bernstein, Daniel Freeman, Reed Irion, Brett Ingersoll, Amy Duwel, Andrew Czarnecki, Brian Daniels, Anilkumar Harapanahalli Achyuta, Bryan McLaughlin
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Publication number: 20170216606Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.Type: ApplicationFiled: February 3, 2016Publication date: August 3, 2017Inventors: Jonathan Bernstein, Daniel Freeman, Reed Irion, Brett Ingersoll, Amy Duwel, Andrew Czarnecki, Brian Daniels, Anilkumar Harapanahalli Achyuta, Bryan McLaughlin
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Publication number: 20170137768Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: ApplicationFiled: November 23, 2016Publication date: May 18, 2017Inventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Patent number: 9632076Abstract: This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.Type: GrantFiled: November 12, 2014Date of Patent: April 25, 2017Assignees: The Charles Stark Draper Laboratory, Inc., The University of South FloridaInventors: Anilkumar Harapanahalli Achyuta, Javier Cuevas, Shivshankar Sundaram, Chris Katnik
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Patent number: 9528082Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: GrantFiled: July 25, 2013Date of Patent: December 27, 2016Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of TechnologyInventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Publication number: 20160235329Abstract: The present disclosure describes systems and methods for recording and stimulating neural and other tissue. The disclosure describes a tissue interface that can be configured as a cuff or a ribbon and includes a plurality of electrodes and ultrasound transducers. The tissue interface is configured to electrically and ultrasonically stimulate tissue, such a muscle tissue and neural tissue. The tissue interface is also configured to monitor the target tissue by recording electrical activity of the target tissue with one or more of the electrodes and image the target tissue with one or more of the ultrasound transducers.Type: ApplicationFiled: December 30, 2015Publication date: August 18, 2016Inventors: Jonathan J. Bernstein, Anilkumar Harapanahalli Achyuta
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Publication number: 20150140581Abstract: This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.Type: ApplicationFiled: November 12, 2014Publication date: May 21, 2015Inventors: Anilkumar Harapanahalli Achyuta, Javier Cuevas, Shivshankar Sundaram, Chris Katnik
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Patent number: 8912006Abstract: This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.Type: GrantFiled: February 4, 2013Date of Patent: December 16, 2014Assignees: The Charles Stark Draper Laboratory, Inc., The University of South FloridaInventors: Anilkumar Harapanahalli Achyuta, Javier Cuevas, Shivshankar Sundaram, Chris Katnik
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Publication number: 20140030752Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: ApplicationFiled: July 25, 2013Publication date: January 30, 2014Inventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman