Abstract: Systems and methods can include one or more processing modules and one or more non-transitory storage modules storing computing instructions configured to run on the one or more processing modules and perform acts. The acts an include providing a bonded network interface on a host server, where the host server can include a plurality of internet protocol (IP) addresses. The acts also can include binding a first database instance container to a first IP address of the plurality of IP addresses of the host server such that a first database deployed inside the first database instance container has direct access to the host server. Systems and methods also can include deploying a first database instance container of a first cluster at a first host server and deploying a second database instance container of a second cluster at the first host server. Other embodiments also are disclosed herein.

Abstract: Systems and methods can include one or more processing modules and one or more non-transitory storage modules storing computing instructions configured to run on the one or more processing modules and perform acts. The acts an include creating a bonded network interface on a host server, the where host server can include a plurality of internet protocol (IP) addresses. The acts also can include binding a first database instance container to a first IP address of the plurality of IP addresses of the host server such that a first database deployed inside the first database instance container has direct access to the host server. Systems and methods also can include deploying a first database instance container of a first cluster at a first host server and deploying a second database instance container of a second cluster at the first host server. Other embodiments also are disclosed herein.

Abstract: Systems and methods can include one or more processing modules and one or more non-transitory storage modules storing computing instructions configured to run on the one or more processing modules and perform acts. The acts an include creating a bonded network interface on a host server, the where host server can include a plurality of internet protocol (IP) addresses. The acts also can include binding a first database instance container to a first IP address of the plurality of IP addresses of the host server such that a first database deployed inside the first database instance container has direct access to the host server. Systems and methods also can include deploying a first database instance container of a first cluster at a first host server and deploying a second database instance container of a second cluster at the first host server. Other embodiments also are disclosed herein.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.