Abstract: Polypeptides are chimeric klebicins, which have one or more translocation domains, one or more receptor-binding domains, and one or more bactericidal domains. Each of the domains is derived from a naturally-occurring klebicin. The killing domain and at least one of the receptor-binding domains are derived from two different naturally-occurring klebicins. The chimeric klebicins achieve improved target cell range and bactericidal activity. The chimeric klebicins can be incorporated into compositions and kits, and can be used in methods of suppressing growth of Klebsiella pneumoniae.

Abstract: The present invention provides chimeric klebicins by combining translocation, receptor-binding, and bactericidal domains originated from different klebicins to achieve improved target cell range and bactericidal activity. Also provided are related compositions, kits, and methods of use of these chimeric klebicins.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

Abstract: The present invention provides chimeric ectolysins useful for selective suppression of certain targeted bacterial species while having little to no effect on closely related non-targeted bacterial species. Specifically, the disclosure provides polypeptides for selective suppression of growth of Staphylococcus aureus and/or S. hominis but not S. epidermidis. Compositions and methods for selective suppression of target bacterial species are also provided.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.