Patents by Inventor Anita Schnyder
Anita Schnyder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7858826Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.Type: GrantFiled: February 27, 2009Date of Patent: December 28, 2010Assignee: Gruenenthal GmbHInventors: Wolfgang Hell, Oswald Zimmer, Markus Kegel, Olaf Schaefer, Felix Spindler, Anita Schnyder, Urs Siegrist, Detlef Heller, Hans-Joachim Drexler
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Publication number: 20100249429Abstract: The present invention relates to a process for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.Type: ApplicationFiled: June 15, 2010Publication date: September 30, 2010Inventors: Donatienne Denni-Dischert, Hans Hirt, Dan Neville, Gottfried Sedelmeier, Anita Schnyder, Nadine Derrien, Daniel Kaufmann
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Publication number: 20090227813Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.Type: ApplicationFiled: February 27, 2009Publication date: September 10, 2009Applicant: Gruenenthal GmbHInventors: Wolfgang Hell, Oswald Zimmer, Markus Kegel, Olaf Schaefer, Felix Spindler, Anita Schnyder, Urs Siegrist, Detlef Heller, Hans-Joachim Drexler
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Patent number: 7528266Abstract: The present invention relates to a first compound having the formula wherein R is halogen, R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkyl, C1-C8haloalkyl, aryl-C1-C8-alkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R3 is C2-C5alkyl or C1-C5haloalkyl, or a salt thereof. The present invention is also directed to a second compound having the formula wherein R is fluorine, bromine, iodine, R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkyl, C1-C8- haloalkyl, aryl-C1-C8alkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R2 is hydrogen, C1-C4alkyl or C1-C4haloalkyl, with the proviso that R1 is different from C1-C8 alkyl or aryl if X is S, R is different from iodine if R2 is methyl, and R is different from fluorine, bromine or iodine if R2 is hydrogen.Type: GrantFiled: October 19, 2007Date of Patent: May 5, 2009Assignee: Syngenta Crop Protection, Inc.Inventors: Anita Schnyder, Marco Passafaro, Thomas Rapold
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Publication number: 20090111995Abstract: The present invention relates to a process for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.Type: ApplicationFiled: December 23, 2008Publication date: April 30, 2009Inventors: Donatienne Denni-Dischert, Hans Hirt, Dan Neville, Gottfried Sedelmeier, Anita Schnyder, Nadine Derrien, Daniel Kaufmann
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Publication number: 20080108813Abstract: The present invention relates a process for the preparation of a compound of formula Ia The process includes the step of reacting a first compound having the formula at elevated reaction temperature in the presence of sulfur in a nucleophilic aromatic substitution reaction with an alkali metal sulfide, disulfide or polysulfide of the formula M2Sq wherein R is halogen, R1SO2 or (R1)2NC(X)O; R1 is C1-C8alkyl, aryl-C1-C8alkyl, C1-C8-haloalkyl or aryl; R2 is hydrogen, C1-C4alkyl or C1-C4haloalkyl, X is O or S; and wherein M is an alkali metal or hydrogen, and q is 1, 2 or a fractional number from 1 to 7,Type: ApplicationFiled: October 19, 2007Publication date: May 8, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Anita SCHNYDER, Marco PASSAFARO, Thomas RAPOLD
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Publication number: 20080097111Abstract: The present invention relates to a first compound having the formula wherein R is halogen, R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkyl, C1-C8haloalkyl, aryl-C1-C8-alkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R3 is C2-C5alkyl or C1-C5haloalkyl, or a salt thereof. The present invention is also directed to a second compound having the formula wherein R is fluorine, bromine, iodine, R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkyl, C1-C8haloalkyl, aryl-C1-C8alkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R2 is hydrogen, C1-C4alkyl or C1-C4haloalkyl, with the proviso that R1 is different from C1-C8 alkyl or aryl if X is S, R is different from iodine if R2 is methyl, and R is different from fluorine, bromine or iodine if R2 is hydrogen.Type: ApplicationFiled: October 19, 2007Publication date: April 24, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Anita Schnyder, Marco Passafaro, Thomas Rapold
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Patent number: 7307175Abstract: Process for the preparation of compounds of formula (I) wherein R is halogen, R1O1R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkly, aryl-C1-C8alkyl, C1-C8haloalkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R2 is hydrogen, C1-C4alkyl or C1-C4haloalkyl, in which process, in a solvent, (1) an aniline derivative of formula (IV) wherein R is as defined above, and R3 is C1-C5alkyl or C1-C5haloalkyl, is diazotised in the presence of a mineral acid to form the corresponding diazonium salt of formul (II) wherein R and R3 are as defined above, Am? is an anion, and m is 1 or 2, (2) the resulting diazonium salt of formula (II) is carbonylated in the presence of a catalyst, CO and optionally a buffer, to form a benzoic acid derivative of formula (III) wherein R and R3 are as defined above, and (3) the benzoic acid derivative of formula (III) is then subjected to benzylic lactonisation in the ortho-position alkyl chain R3 in the presence of a free-radical initiator and a halogenating agent.Type: GrantFiled: May 21, 2002Date of Patent: December 11, 2007Assignee: Syngenta Crop Protection, Inc.Inventors: Anita Schnyder, Marco Passafaro, Thomas Rapold
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Patent number: 7208174Abstract: The present invention provides a non-covalent coupling method for the preparation of sterically stabilized lipsomes which may be used for targeted drug delivery, e.g., pegylated liposomes. The method simplifies the attachment of targeting vectors to sterically stabilized liposomes. The present invention also provides a liposome composition comprising a compound of the formula and a compound of the formula Z-Y, wherein Z is any compound capable of binding to a cellular receptor, and X and Y are compounds which can interact with each other non-convalently, and wherein the substituents n, F1 and F2 are as provided in the specification.Type: GrantFiled: December 14, 2004Date of Patent: April 24, 2007Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Huwyler, Anita Schnyder
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Patent number: 7074787Abstract: The invention relates to novel N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives of the general formula (I) wherein the sum of (m+p) together is 0, 1, 2 or 3; n and q are independently of each other 0 or 1, and the sum of (m+p+q) together is 1, 2, 3 or 4; R1 is hydrogen, halogen, alkoxy, haloalkyl, haloalkoxy or alkyl; R2 is hydrogen, C1–C6-alkyl, C1–C6-haloalkyl or C1–C6-alkoxy; R2A is hydrogen, C1–C6-alkyl, C3–C4-alkenyl or C3–C4-alkynyl; each of R3, R4, R5 and R6 is, independently of the others, hydrogen, C1–C6-alkyl, C1–C6-haloalkyl, hydroxy-C1–C6-alkyl or C1–C6-alkoxy-C1–C6-alkyl, or the ring members CR3R4 or CR5R6 or CR2R2A are independently of each other a carbonyl group (C?O) or a group C?S; X is C?O, C?S, S?O or O?S?O; Y is O, S, C?O, CH2, —N(R8)—, —O—N(R8)—, —N(R8)—O— or NH—; R7 is hydrogen, C1–C4-alkyl, C3–C4-alkenyl, C3–C4-alkynyl, —CH2OR8, CH2SR8, —C(O)R8, —C(O)OR8, SO2R8, SOR8 or SR8; and R8 is C1–C8-alkyl, C1–C8-alkoxyalkyl, C1–C8 haloalkyl or phenylC1–C2-alkyl wherein the phenyl may be subsType: GrantFiled: December 20, 2001Date of Patent: July 11, 2006Assignee: Syngenta Crop Protection, Inc.Inventors: Martin Eberle, Hugo Ziegler, Fredrik Cederbaum, Peter Ackermann, Anita Schnyder
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Publication number: 20060069268Abstract: The present invention relates to a process for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.Type: ApplicationFiled: September 22, 2003Publication date: March 30, 2006Inventors: Donatienne Denni-Dischert, Hans Hirt, Dan Neville, Gottfried Sedelmeier, Anita Schnyder, Nadine Derrien, Daniel Kaufmann
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Publication number: 20050152963Abstract: The present invention provides a non-covalent coupling method for the preparation of sterically stabilized lipsomes which may be used for targeted drug delivery, e.g., pegylated liposomes. The method simplifies the attachment of targeting vectors to sterically stabilized liposomes. The present invention also provides a liposome composition comprising a compound of the formula and a compound of the formula Z-Y, wherein Z is any compound capable of binding to a cellular receptor, and X and Y are compounds which can interact with each other non-convalently, and wherein the substituents n, F1 and F2 are as provided in the specification.Type: ApplicationFiled: December 14, 2004Publication date: July 14, 2005Inventors: Joerg Huwyler, Anita Schnyder
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Patent number: 6784295Abstract: Process for the coupling of a) nucleophiles selected from the group alcohols, thioles, amines, metallised hydrocarbons, CH-acidic compounds and metal cyanides, or of b) carbon monoxide mixed with water, alcohols, ammonia, primary or secondary amines, to organic compounds selected from the group of leaving-group-containing aromatics, hetero-aromatics with a C-bonded leaving group, aromatic or hetero-aromatic methyl compounds with a leaving group bonded to the methyl group, ethylenically unsaturated organic compounds with a C-bonded leaving group, or organic allyl compounds with a leaving group in allyl position, or c) vinyl compounds with leaving-group-containing aromatics, whilst cleaving the leaving group in the presence of Pd complexes with monophospholine ligands as the catalyst, whereby variants b) and c) are carried out in the presence of an inorganic base or organic nitrogen base, the process being characterised in that the Pd complex contains secondary monophosphines with aliphatic, branched or cyclType: GrantFiled: March 3, 2003Date of Patent: August 31, 2004Assignee: Solvias AGInventors: Adriano Indolese, Anita Schnyder
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Publication number: 20040158080Abstract: Process for the preparation of compounds of formula (I) wherein R is halogen, R1O1R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkly, aryl-C1-C8alkyl, C1-C8haloalkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R2 is hydrogen, C1-C4alkyl or C1-C4haloalkyl, in which process, in a solvent, (1) an aniline derivative of formula (IV) wherein R is as defined above, and R3 is C1-C5alkyl or C1-C5haloalkyl, is diazotised in the presence of a mineral acid to form the corresponding diazonium salt of formul (II) wherein R and R3 are as defined above, Am− is an anion, and m is 1 or 2, (2) the resulting diazonium salt of formula (II) is carbonylated in the presence of a catalyst, CO and optionally a buffer, to form a benzoic acid derivative of formula (III) wherein R and R3 are as defined above, and (3) the benzoic acid derivative of formula (III) is then subjected to benzylic lactonisation in the ortho-position alkyl chain R3 in the presence of a free-radical initiator and a halogenating agent.Type: ApplicationFiled: April 7, 2004Publication date: August 12, 2004Inventors: Anita Schnyder, Marco Passafaro, Thomas Rapold
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Publication number: 20040063937Abstract: The invention relates to novel N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives of the general formula (1) wherein the sum of (m+p) together is 0, 1, 2 or 3; n and q are independently of each other 0 or 1, and the sum of (m+p+q) together is 1, 2, 3 or 4; R1 is hydrogen, halogen, alkoxy, haloalkyl, haloalkoxy or alkyl; R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl or C1-C6-alkoxy; R2A is hydrogen, C1-C6-alkyl, C3-C4-alkenyl or C3-C4-alkynyl; each of R3, R4, R5 and R6 is, independently of the others, hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, hydroxy-C1-C6-alkyl or C1-C6-alkoxy-C1-C6-alkyl, or the ring members CR3R4 or CR5R6 or CR2R2A are independently of each other a carbonyl group (C═O) or a group C═S; X is C═O, C═S, S═O or O═S=O; Y is O, S, C═O, CH2A, —N(R8)—, —O—N(R8)—, —N(R8)—O— or NH—; R7 is hydrogen, C1-C4-alkyl, C3-C4-alkenyl, C3-C4-alkynyl, —CH2OR8, CH2SR8, —C(O)R8, —C(O)OR8,Type: ApplicationFiled: June 25, 2003Publication date: April 1, 2004Inventors: Martin Eberle, Hugo Ziegler, Fredrik Cederbaum, Peter Ackermann, Anita Schnyder
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Publication number: 20030181688Abstract: Process for the coupling ofType: ApplicationFiled: March 3, 2003Publication date: September 25, 2003Inventors: Adriano Indolese, Anita Schnyder
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Patent number: 6548684Abstract: Process for the coupling of a) nucleophiles selected from the group alcohols, thioles, amines, metallised hydrocarbons, CH-acidic compounds and metal cyanides, or of b) carbon monoxide mixed with water, alcohols, ammonia, primary or secondary amines, to organic compounds selected from the group of leaving-group-containing aromatics, hetero-aromatics with a C-bonded leaving group, aromatic or hetero-aromatic methyl compounds with a leaving group bonded to the methyl group, ethylenically unsaturated organic compounds with a C-bonded leaving group, or organic allyl compounds with a leaving group in allyl position, or c) vinyl compounds with leaving-group-containing aromatics, whilst cleaving the leaving group in the presence of Pd complexes with monophospholine ligands as the catalyst, whereby variants b) and c) are carried out in the presence of an inorganic base or organic nitrogen base, the process being characterised in that the Pd complex contains secondary monophosphines with aliphatic, branched or cycType: GrantFiled: March 6, 2001Date of Patent: April 15, 2003Assignee: Solvias AGInventors: Adriano Indolese, Anita Schnyder
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Patent number: 6441233Abstract: A process for the preparation of primary aromatic carboxamides by the carbonylation of an aromatic compound, which contains at least one leaving group, with carbon monoxide, in the presence of a homogeneous or heterogeneous Pd catalyst and at least stoichiometric amounts of an amidation agent at elevated temperatures, which is characterized in that a primary carboxamide or a primary urethane is used as the amidation agent, and the reaction is carried out in the presence of an acylation catalyst.Type: GrantFiled: June 21, 2001Date of Patent: August 27, 2002Assignee: Solvias AGInventors: Anita Schnyder, Adriano Indolese, Gerald Mehltretter
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Publication number: 20010037042Abstract: Process for the coupling ofType: ApplicationFiled: March 6, 2001Publication date: November 1, 2001Inventors: Adriano Indolese, Anita Schnyder
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Patent number: 6031126Abstract: A process for the production of a fluorescent whitening agent of formula: ##STR1## in which X and Z are as defined herein, comprising A) rearranging a hydrazobenzene compound having the formula: ##STR2## in which Z is as defined herein, to produce in situ a compound having the formula: ##STR3## B) diazotising the compound of formula (3) to produce a compound having the formula: ##STR4## in which Z has its previous significance and G.sub.1 is a counter ion; and C) reacting the compound of formula (4) with 2 moles of a compound having the formula: ##STR5## in which X and n have their previous significance, in the presence of an inorganic or organic palladium salt, or a mixture thereof, as catalyst-precursor, to produce a compound having the formula (1).Type: GrantFiled: April 23, 1998Date of Patent: February 29, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: Victor Eliu, Werner Kanert, Adriano Indolese, Philipp Wyser, Anita Schnyder