Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: In one aspect, provided herein are methods for predicting the responsiveness of DLBCL patients to treatment with lenolidomide or Compound A; or a stereoisomer thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate thereof; or a polymorph thereof utilizing biomarkers or classifiers that correlate with responsiveness to one of these drugs. In another aspect, provided herein are methods for treating a DLBCL patient determined to be responsive to treatment with lenolidomide or Compound A; or a stereoisomer thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate thereof; or a polymorph thereof utilizing biomarkers or classifiers (or output thereof) that correlate with responsiveness to one of these drugs.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A spectroscopically active nano-particle assembly is provided. The nano-particle assembly includes a cluster of metallic nano-particles. A first protective coating is formed over a first side of the cluster, and a second protective coating is formed over a second side of the cluster, wherein the second side of the cluster is opposite the first side.

Abstract: A topical ophthalmic formulation of an LXR agonist that could be used for treating dry-eye disease. Examples of LXR agonists that could be used include naturally occurring oxysterol compounds, such as ouabagenin or hyodeoxycholic acid, or synthetic, non-sterol compounds such as IMB-151 or T0901317. The LXR agonist compound may be encapsulated within biodegradable nanoparticles, such as poly(lactic/glycolic) acid (PLGA) nanoparticles, micelles, or liposomes. Experimental work establishing proof-of-concept has been performed.

Abstract: The present invention relates in general to bacterial cells having genetic alterations that result in increased expression of a protein of interest and methods of making and using such cells. Aspects of the present invention include altered Gram positive microorganisms having one or more a genetic alterations that reduce the expression of a gene in the sin operon, thereby resulting in the enhanced expression of one or more proteins of interest.

Abstract: The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: An optoelectronic assembly is disclosed. The disclosed assembly includes one or more lasers formed on a first substrate, and a programmable driver circuit formed on a second substrate configured as an integrated circuit. The first and second substrates are mounted on a third substrate in a stacked arrangement.

Abstract: A retrieving system for retrieving information concealed within a sequence of symbols. The system includes a decoder configurable using rule information and operable when so configured to retrieve the information concealed within the sequence of symbols by applying to the sequence of symbols at least one decoder rule determined by the configuration of the encoder.

Abstract: A system and method for providing reminding assistance. The system includes at least one processing component, at least one memory component, and a memory impairment detection and assistance environment. The memory impairment detection and assistance environment includes a reminding database, an analysis module, and an assistance module. The analysis module includes an attribute analyzer configured to determine values for attributes based on memory impairment detection data and a memory evaluator configured to determine that an attribute has a value that crosses a threshold attribute value. The assistance module includes a reminding assistant configured to receive a memory impairment signal and, in response, generate a reminder that includes information selected from the reminding database.

Abstract: A system may involve persistent storage defining primitive data types and compound data types, where the compound data types include objects and arrays, where the objects contain sets of elements that have various primitive data types, compound data types, or both, and where the arrays contain sets of elements that all have one particular primitive data type or compound data type. The system may also involve one or more processors configured to provide a representation of a graphical user interface for designing a hierarchy of elements, each of the elements therein having a data type that is either a primitive data type or a compound data type, where elements in the hierarchy are associated with data type change controls, and where object elements in the hierarchy are: (i) associated with child element controls, and (ii) represented as collapsible menu items that can either display or hide their child elements.

Abstract: The present disclosure includes systems and a methods for ingestion and processing of data in large volumes and varied data models. The system consists of a data intake adapter, tagging service, relation service, query service, persistence service and physical storage medium. The data intake adapters are implemented to support required data formats and models. The invention includes a method enabling assignments of tags to any data element that can be referenced in the system, including in some embodiments tables, rows, columns, data points, nodes, vectors, lists or other types. The invention further includes a method of data representation for tags data using hash tree data structures. The disclosure also includes a relations mechanism and service that is capable of defining relations between data elements. The disclosed system includes also a query service that leverages the internal data structures to provide efficient lookup and retrieval methods supporting vast range of analytical use cases.

Abstract: A car includes: a left side and a right side; a first light emitter coupled to the left side of the car; a second light emitter coupled to the right side of the car; a first camera coupled to the left side of the car, the first camera configured to generate a first image; a second camera coupled to the right side of the car, the second camera configured to generate a second image; wherein the first camera and the second camera are located closer to a front end of the car than a back end of the car.

Abstract: Disclosed is a device, method and computer readable media for determining the adequacy of Cardiopulmonary Resuscitation (CPR). The device comprises an electrical source generator, an electrical signal sensor receiving a signal from the electrical source generator and a microprocessor. The microprocessor determines changes in impedance of the patient based on the signal received from the electrical signal sensor. Software executing on the microprocessor determines at least one of intrathoracic volume, change in intrathoracic volume, rate of compression, depth of compression, respiratory volume, and respiratory rate based on the change of impedance of the patient and outputs a signal indicating the adequacy of ventilation and compressions.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: An apparatus includes a sample carrier having wells. Each of the wells has sides and a floor forming an interior. A surface enhanced Raman spectroscopy (SERS) structure is within the interior of each of the wells. A pneumatic port is connected to the interior of each of the wells. A pneumatic passage is connected to the pneumatic ports.

Abstract: The present application relates to methods of using compounds of Formulae (I) and (II): for treatment of various cancers. The application further relates to pharmaceutical compositions and uses comprising the compounds of the application.

Abstract: A system and method for providing reminding assistance. The system includes at least one processing component, at least one memory component, and a memory impairment detection and assistance environment. The memory impairment detection and assistance environment includes a reminding database, an analysis module, and an assistance module. The analysis module includes an attribute analyzer configured to determine values for attributes based on memory impairment detection data and a memory evaluator configured to determine that an attribute has a value that crosses a threshold attribute value. The assistance module includes a reminding assistant configured to receive a memory impairment signal and, in response, generate a reminder that includes information selected from the reminding database.