Patents by Inventor Anitha Devi Jayaprakash

Anitha Devi Jayaprakash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DETERMINING RECOMBINATION DIVERSITY AT A GENOMIC LOCUS
    Publication number: 20210388344
    Abstract: The present disclosure relates to methods for determining recombination diversity at a genomic locus of interest. The method includes fragmenting nucleic acids isolated from immune cells, ligating adaptors to the fragmented or amplified nucleic acids, and selectively amplifying nucleic acids containing a recombined junction at the genomic locus of interest. Selective amplification is achieved by using a first primer that hybridizes to an adaptor sequence and a second primer that hybridizes at a constant region downstream of the recombined junction. The selectively amplified nucleic acids may be sequences and analyzed to determine recombination diversity at the genomic locus.
    Type: Application
    Filed: February 12, 2021
    Publication date: December 16, 2021
    Inventors: Anitha Devi Jayaprakash, Andrew Chess, Ravi Sachidanandam
  • Methods for determining recombination diversity at a genomic locus
    Patent number: 10920220
    Abstract: The present disclosure relates to methods for determining recombination diversity at a genomic locus of interest. The method includes fragmenting nucleic acids isolated from immune cells, ligating adaptors to the fragmented or amplified nucleic acids, and selectively amplifying nucleic acids containing a recombined junction at the genomic locus of interest. Selective amplification is achieved by using a first primer that hybridizes to an adaptor sequence and a second primer that hybridizes at a constant region downstream of the recombined junction. The selectively amplified nucleic acids may be sequences and analyzed to determine recombination diversity at the genomic locus.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 16, 2021
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Anitha Devi Jayaprakash, Andrew Chess, Ravi Sachidanandam
  • METHODS FOR DETERMINING RECOMBINATION DIVERSITY AT A GENOMIC LOCUS
    Publication number: 20170342408
    Abstract: The present disclosure relates to methods for determining recombination diversity at a genomic locus of interest. The method includes fragmenting nucleic acids isolated from immune cells, ligating adaptors to the fragmented or amplified nucleic acids, and selectively amplifying nucleic acids containing a recombined junction at the genomic locus of interest. Selective amplification is achieved by using a first primer that hybridizes to an adaptor sequence and a second primer that hybridizes at a constant region downstream of the recombined junction. The selectively amplified nucleic acids may be sequences and analyzed to determine recombination diversity at the genomic locus.
    Type: Application
    Filed: November 20, 2015
    Publication date: November 30, 2017
    Inventors: Anitha Devi Jayaprakash, Andrew Chess, Ravi Sachidanandam