Patents by Inventor Anitha Thomas

Anitha Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for transfecting resistant cell types
    Patent number: 11679159
    Abstract: A reagent composition for delivery nucleic acid therapeutics to cells is provided. The reagent includes ionizable lipid, structural lipid, and a stabilizing agent which improves the transfection efficiency of nucleic acids, and leaves transfected cells viable. The 5 transfection reagent is effective in plasmid and mRNA delivery, and in neurons and progenitor-like cells. It may be used for ex vivo cell therapy.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: June 20, 2023
    Assignee: Precision Nanosystems ULC
    Inventors: Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara L. Fernandez
  • Compositions for transfecting resistant cell types
    Patent number: 11572575
    Abstract: A transfection reagent composition comprising: 30-60 MOL. % of a cationic lipid, or a pharmaceutical acceptable salt thereof; 10-60 MOL % of a structural lipid; 10-20 MOL % of a triglyceride; and 0.1 to about 10 MOL. % of a stabilizing agent, is provided. The transfection agent is effective in transfecting cells, particularly neurons, with siRNA, mRNA and plasmid nucleic acid, Sand maintaining viability of the cells as well as activity of the delivered nucleic acid.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 7, 2023
    Assignee: Precision NanoSystems ULC
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
  • IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY
    Publication number: 20220396548
    Abstract: The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) where R1 features an amine group, particularly useful in the formulation of lipid particles including nucleic acid therapeutic agents, or proteins, or both, and for delivery of nucleic acid and protein therapeutics to cells in vivo or ex vivo, including anticancer and vaccine applications.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 15, 2022
    Inventors: Nikita JAIN, Anitha THOMAS, Andrew William BROWN
  • IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY
    Publication number: 20220378917
    Abstract: The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) Wherein R1 includes an amino group. These compounds are particularly useful in the formulation and in vivo and ex vivo delivery of nucleic acid and protein therapeutics for preparing and implementing T cell transfection, gene editing, cancer therapies, cancer prophylactics, and in the preparation of vaccines.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 1, 2022
    Inventors: Anitha THOMAS, Nikita JAIN, Andrew William BROWN
  • Nonviral Modification of T Cell Gene Expression
    Publication number: 20220162552
    Abstract: There is provided a lipid mix composition comprising ionizable lipid, a structural lipid such as DSPC, a sterol, and a surfactant such as polysorbate 80, polyoxyethylene (10) stearyl ether, polyoxyethylene (20) stearyl ether, or D-?-Tocopherol polyethylene glycol 1000 succinate. The lipid mix compositions find particular use in transfecting difficult to transfect cells and maintaining the viability of those cells. The lipid mix compositions are particularly well suited to T cell transfection ex vivo.
    Type: Application
    Filed: April 14, 2020
    Publication date: May 26, 2022
    Applicant: Precision NanoSystems Inc.
    Inventors: Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara Fernandez
  • Compositions for Transfecting Resistant Cell Types
    Publication number: 20210284998
    Abstract: A transfection reagent composition comprising: 30-60 MOL % of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL % structural lipid; a sterol and 0.1 to about 10 MOL % of a stabilizing agent is provided. The reagent is particularly adapted for neuron and related cell types. A method of manufacturing LNP including nucleic acid for selective uptake into either neurons or astrocytes or neural progenitor cells is also provided.
    Type: Application
    Filed: October 2, 2017
    Publication date: September 16, 2021
    Applicant: Precision NanoSystems Inc.
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
  • Compositions for Transfecting Resistant Cell Types
    Publication number: 20210162052
    Abstract: A reagent composition for delivery nucleic acid therapeutics to cells is provided. The reagent includes ionizable lipid, structural lipid, and a stabilizing agent which improves the transfection efficiency of nucleic acids, and leaves transfected cells viable. The 5 transfection reagent is effective in plasmid and mRNA delivery, and in neurons and progenitor-like cells. It may be used for ex vivo cell therapy.
    Type: Application
    Filed: April 15, 2019
    Publication date: June 3, 2021
    Applicant: Precision NanoSystems Inc.
    Inventors: Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara L. Fernandez
  • Disposable microfluidic cartridge
    Patent number: 10597291
    Abstract: The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 24, 2020
    Assignee: The University of British Columbia
    Inventors: Andre Wild, Timothy Leaver, Colin Walsh, Gesine Heuck, Anitha Thomas, Aysha Ansari, Kevin Ou, Robert James Taylor, Euan Ramsay
  • Compositions for Transfecting Resistant Cell Types
    Publication number: 20190292566
    Abstract: A transfection reagent composition comprising: 30-60 MOL. % of a cationic lipid, or a pharmaceutical acceptable salt thereof; 10-60 MOL % of a structural lipid; 10-20 MOL % of a triglyceride; and 0.1 to about 10 MOL. % of a stabilizing agent, is provided. The transfection agent is effective in transfecting cells, particularly neurons, with siRNA, mRNA and plasmid nucleic acid, Sand maintaining viability of the cells as well as activity of the delivered nucleic acid.
    Type: Application
    Filed: December 19, 2017
    Publication date: September 26, 2019
    Applicant: Precision NanoSystems Inc.
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
  • DISPOSABLE MICROFLUIDIC CARTRIDGE
    Publication number: 20180111830
    Abstract: The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
    Type: Application
    Filed: October 27, 2017
    Publication date: April 26, 2018
    Applicant: The University of British Columbia
    Inventors: Andre Wild, Timothy Leaver, Colin Walsh, Gesine Heuck, Anitha Thomas, Aysha Ansari, Kevin Ou, Robert James Taylor, Euan Ramsay