Patents by Inventor Anja Boisen
Anja Boisen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240035939Abstract: The invention relates to a method for preparing a substrate comprising a sample reception area and a sensing area. The method comprises the steps of: 1) applying a sample on the sample reception area; 2) rotating the substrate around a predetermined axis; 3) during rotation, at least part of the liquid travels from the sample reception area to the sensing area due to capillary forces acting between the liquid and the substrate; and 4) removing the wave of particles and liquid formed at one end of the substrate. The sensing area is closer to the predetermined axis than the sample reception area. The sample comprises a liquid part and particles suspended therein.Type: ApplicationFiled: October 9, 2023Publication date: February 1, 2024Applicant: Danmarks Tekniske UniversitetInventors: Onur DURUCAN, Michael Stenbaek SCHMIDT, Tomas RINDZEVICIUS, Anja BOISEN
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Publication number: 20240000708Abstract: The present invention relates to a drug delivery platform. In particular, it relates to a foil-based drug delivery platform for delivery to the intestine.Type: ApplicationFiled: March 31, 2021Publication date: January 4, 2024Inventors: Anja Boisen, Lasse Hølund Eklund Thamdrup, Jacob Rune Jørgensen, Thomas Rades, Anette Müllertz, Mahdi Ghavami, Khorshid Kam Guyan
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Patent number: 11815440Abstract: The invention relates to a method for preparing a substrate (105a) comprising a sample reception area (110) and a sensing area (111). The method comprises the steps of: 1) applying a sample on the sample reception area; 2) rotating the substrate around a predetermined axis; 3) during rotation, at least part of the liquid travels from the sample reception area to the sensing area due to capillary forces acting between the liquid and the substrate; and 4) removing the wave of particles and liquid formed at one end of the substrate. The sensing area is closer to the predetermined axis than the sample reception area. The sample comprises a liquid part and particles suspended therein.Type: GrantFiled: May 1, 2017Date of Patent: November 14, 2023Assignee: Danmarks Tekniske UniversitetInventors: Onur Durucan, Michael Stenbaek Schmidt, Tomas Rindzevicius, Anja Boisen
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Patent number: 11788967Abstract: An apparatus for carrying out Raman spectroscopy on a sample includes a light source for providing a beam of excitation radiation, and an optical system including a spectrograph. The spectrograph includes a grating that divides a beam of scattered light into a spectrum of spatially separated wavelength components and to direct a portion of the spectrum to a detector. The spectrograph includes: 1) a first lens system for focusing the portion of the spectrum onto the detector and 2) a second lens system-configured to provide a focal plane with focal point in the optical path for focusing the beam of excitation radiation and/or the beam of scattered radiation at the focal point. The apparatus including a reference sample arranged in the focal plane, in particular at the focal point, for obtaining a reference spectrum from the reference sample.Type: GrantFiled: January 23, 2019Date of Patent: October 17, 2023Assignee: DANMARKS TEKNISKE UNIVERSITETInventors: Oleksii Ilchenko, Tomas Rindzevicius, Anja Boisen, Roman Slipets
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Publication number: 20230210994Abstract: The present invention relates to the in vitro use of a group of cell-penetrating conjugate systems or a formulation incorporating the same for transporting e.g. therapeutically active agents, such as chemotherapeutics, insulin and immunosuppressants across the cellular membranes of mammalian cells, including human cells. The invention also relates to an in vitro methods of transporting physiologically active agents, such as therapeutics, across cell-membranes by using the cell-penetrating conjugate systems according to the present invention as well as the cell-penetrating conjugate systems for use in treatment of cancer, diabetes and for use in immunotherapy.Type: ApplicationFiled: April 6, 2020Publication date: July 6, 2023Inventors: Sarvesh Kumar Srivastava, Gael Clergeaud Veiga, Anja Boisen
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Publication number: 20230181172Abstract: The present disclosure relates to an ingestible device for sampling of the gastrointestinal tract. In particular, the device comprises an oral delivery capsule comprising a container having on the inside a hydrogel pre-polymer. The hydrogel prepolymer is capable of polymerising in situ, such as within the gastrointestinal tract, thereby collecting a sample of the gastrointestinal lumen by absorbing the lumen and its contents into the formed hydrogel.Type: ApplicationFiled: May 27, 2021Publication date: June 15, 2023Applicant: Danmarks Tekniske UniversitetInventors: Sarvesh Kumar SRIVASTAVA, Anja BOISEN
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Publication number: 20230003576Abstract: An apparatus for carrying out polarization resolved Raman spectroscopy on a sample (11), in particular a crystalline or polycrystalline sample, the apparatus comprises: at least one light source (13, 87, 93, 95, 97), in particular at least one laser, for providing excitation radiation to a surface of the sample (11), an optical system which is configured to simultaneously collect at least one on-axis Raman beam (21, 109) and at least one off-axis Raman beam (23, 111) from Raman light scattered by the sample (11) in response to exposing the surface to the excitation radiation, the at least one on-axis Raman beam (21, 109) being scattered from the sample (11) in a direction that is aligned with an optical axis of an objective (41) of the optical system for collecting the at least one on-axis Raman beam (21, 109), the at least one off-axis Raman beam being scattered from the sample in a direction that is inclined with regard to an optical axis of an objective (41) of the optical system for collecting the at lType: ApplicationFiled: December 4, 2020Publication date: January 5, 2023Inventors: Oleksii ILCHENKO, Anja BOISEN, Yurii PILHUN, Andrii KUTSYK, Florian BACHMANN
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Patent number: 11397109Abstract: An apparatus for carrying out polarization resolved Raman spectroscopy on a sample (15), in particular a crystalline sample, comprises: at least one light source (11), in particular at least one laser, for providing excitation radiation to a sample (15), a spectrograph (31) for dividing light from the sample (15), in particular Raman scattered light from the sample (15), into at least one spectrum of spatially separated wavelength components and for directing at least a portion of the at least one spectrum to a detector (29), in particular a CCD detector, a polarization state control element (27) for the light from the sample (15), the polarization state control element (27) being arranged in a light path of at least one light beam (25) traveling from the sample (15) towards the detector (29), and the polarization state control element (27) comprising at least one polarization sensitive optical element (45, 47), in particular a Wollaston prism, the at least one polarization sensitive optical element beingType: GrantFiled: June 28, 2019Date of Patent: July 26, 2022Assignee: Danmarks Tekniske UniversitetInventors: Oleksii Ilchenko, Anja Boisen, Roman Slipets
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Publication number: 20220111384Abstract: A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.Type: ApplicationFiled: December 20, 2021Publication date: April 14, 2022Inventors: Anja Boisen, En-Te Hwu, Kinga Iudith Zor, Sriram Thoppe Ranjendran, Laura Serioli
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Publication number: 20220008923Abstract: A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.Type: ApplicationFiled: October 24, 2019Publication date: January 13, 2022Inventors: Anja Boisen, En-Te Hwu, Kinga Iudith Zor, Sriram Thoppe Ranjendran, Laura Serioli
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Publication number: 20210270669Abstract: An apparatus for carrying out polarization resolved Raman spectroscopy on a sample (15), in particular a crystalline sample, comprises: at least one light source (11), in particular at least one laser, for providing excitation radiation to a sample (15), a spectrograph (31) for dividing light from the sample (15), in particular Raman scattered light from the sample (15), into at least one spectrum of spatially separated wavelength components and for directing at least a portion of the at least one spectrum to a detector (29), in particular a CCD detector, a polarization state control element (27) for the light from the sample (15), the polarization state control element (27) being arranged in a light path of at least one light beam (25) traveling from the sample (15) towards the detector (29), and the polarization state control element (27) comprising at least one polarization sensitive optical element (45, 47), in particular a Wollaston prism, the at least one polarization sensitive optical element beingType: ApplicationFiled: June 28, 2019Publication date: September 2, 2021Inventors: Oleksii ILCHENKO, Anja BOISEN, Roman SLIPETS
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Publication number: 20210072158Abstract: An apparatus for carrying out Raman spectroscopy on a sample includes a light source for providing a beam of excitation radiation, and an optical system including a spectrograph. The spectrograph includes a grating that divides a beam of scattered light into a spectrum of spatially separated wavelength components and to direct a portion of the spectrum to a detector. The spectrograph includes: 1) a first lens system for focusing the portion of the spectrum onto the detector and 2) a second lens system-configured to provide a focal plane with focal point in the optical path for focusing the beam of excitation radiation and/or the beam of scattered radiation at the focal point. The apparatus including a reference sample arranged in the focal plane, in particular at the focal point, for obtaining a reference spectrum from the reference sample.Type: ApplicationFiled: January 23, 2019Publication date: March 11, 2021Applicant: DANMARKS TEKNISKE UNIVERSITETInventors: Oleksii ILCHENKO, Tomas RINDZEVICIUS, Anja BOISEN, Roman SLIPETS
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Publication number: 20190145875Abstract: The invention relates to a method for preparing a substrate (105a) comprising a sample reception area (110) and a sensing area (111). The method comprises the steps of: 1) applying a sample on the sample reception area; 2) rotating the substrate around a predetermined axis; 3) during rotation, at least part of the liquid travels from the sample reception area to the sensing area due to capillary forces acting between the liquid and the substrate; and 4) removing the wave of particles and liquid formed at one end of the substrate. The sensing area is closer to the predetermined axis than the sample reception area. The sample comprises a liquid part and particles suspended therein.Type: ApplicationFiled: May 1, 2017Publication date: May 16, 2019Applicant: Danmarks Tekniske UniversitetInventors: Onur DURUCAN, Michael Stenbaek SCHMIDT, Tomas RINDZEVICIUS, Anja BOISEN
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Patent number: 9784735Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.Type: GrantFiled: March 24, 2014Date of Patent: October 10, 2017Assignee: Danmarks Tekniske UniversitetInventors: Marco Donolato, Filippo Bosco, Mikkel Fougt Hansen, Anja Boisen, En-Te Hwu
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Patent number: 9705017Abstract: The present invention relates to a plasma texturing method for silicon based solar cells and the nanostructured silicon solar cells produced thereof. The silicon based solar cell comprises a silicon substrate having in at least part of its surface conical shaped nanostructures having an average height between 200 and 450 nm and a pitch between 100 and 200 nm, thereby achieving low reflectance and minimizing surface charge recombination.Type: GrantFiled: September 26, 2014Date of Patent: July 11, 2017Assignee: Danmarks Tekniske UniversitetInventors: Rasmus Schmidt Davidsen, Ole Hansen, Anja Boisen, Michael Stenbæk Schmidt
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Patent number: 9671392Abstract: The present invention relates to a multisensor array for detection of analytes in the gas phase or in the liquid phase, comprising at least two different chemo-selective compounds represented by the general formula (I) wherein the hetero atoms X1-X4 and the substituents R1-R4 are defined in the specification and the dashed bonds represent independently of each other either a single bond or a double bond. Said chemo-selective compounds are capable of individually changing physicochemical properties when exposed to analytes or analyte mixtures and these changes can be detected by a transducer or an array of transducers. The present invention does also relate to the use of at least two different chemo-selective compounds in a sensor array, a method for preparation of such sensor arrays and the use of said sensor arrays. Furthermore the present invention relates to methods for detecting and identifying analytes or mixtures thereof in the gas phase or in the liquid phase.Type: GrantFiled: March 31, 2011Date of Patent: June 6, 2017Assignee: Danmarks Tekniske UniversitetInventors: Jan Oskar Jeppsen, Natalie Kostesha, Carsten Johnsen, Kent Albin Nielsen, Anja Boisen, Mogens Havsteen Jakobsen
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Publication number: 20160377609Abstract: The present invention relates to an apparatus for detecting compounds, the apparatus having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices.Type: ApplicationFiled: November 17, 2015Publication date: December 29, 2016Inventors: Anja Boisen, Filippo Giacomo Bosco, En-Te Hwu
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Publication number: 20160240703Abstract: The present invention relates to a plasma texturing method for silicon based solar cells and the nanostructured silicon solar cells produced thereof. The silicon based solar cell comprises a silicon substrate having in at least part of its surface conical shaped nanostructures having an average height between 200 and 450 nm and a pitch between 100 and 200 nm, thereby achieving low reflectance and minimizing surface charge recombination.Type: ApplicationFiled: September 26, 2014Publication date: August 18, 2016Inventors: Rasmus Schmidt Davidsen, Ole Hansen, Anja Boisen, Michael Stenbæk Schmidt
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Publication number: 20160206513Abstract: The present invention relates to mass production of micro-containers containing an active ingredient and methods for manufacturing micro-containers containing an active ingredient.Type: ApplicationFiled: September 1, 2014Publication date: July 21, 2016Inventors: Johan NAGSTRUP, Stephan Sylvest KELLER, Anja BOISEN, Ritika Singh PETERSEN
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Patent number: 9395343Abstract: The present invention relates to methods and devices for determining the weight of small particles, typically being nano-sized particles by use of resonating fibers in the form of elongate members being driven into resonance by an actuator or e.g. thermal noise/fluctuation. The frequency shift in resonance frequency due to depositing of nano-sized particles is correlated with the mass deposited on the elongate member and the vibration frequency of the elongate member is determined by a detector. The read-out from the detector is transformed into a mass deposited on the elongate member. Particles are deposited by letting a fluid with the particles flow past the elongate member.Type: GrantFiled: November 2, 2012Date of Patent: July 19, 2016Assignee: Danmarks Tekniske UniversitetInventors: Silvan Schmid, Anja Boisen