Abstract: The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions.

Abstract: The present inventions relates to the preparation of 3,3,5-trimethylcyclohexylidene bisphenol. Especially, the present invention relates to the preparation of 3,3,5-trimethylcyclohexylidene bisphenol from 3,3,5-trimethylcyclohexanone and phenol in the presence of a gaseous acidic catalyst. The preparation comprises a first drying step and a second drying step wherein in the second drying step the temperature is increased in comparison to first drying step or in the second drying step the pressure is lowered in comparison to first drying step, or in second drying step both the temperature is increased and the pressure is lowered in comparison to the first drying step (d1).

Abstract: The present inventions relates to the preparation of 3,3,5-trimethylcyclohexylidene bisphenol. Especially, the present invention relates to the preparation of 3,3,5-trimethylcyclohexylidene bisphenol from 3,3,5-trimethylcyclohexanone and phenol in the presence of a gaseous acidic catalyst. The preparation comprises a first drying step and a second drying step wherein in the second drying step the temperature is increased in comparison to first drying step or in the second drying step the pressure is lowered in comparison to first drying step, or in second drying step both the temperature is increased and the pressure is lowered in comparison to the first drying step (d1).

Abstract: A device for coating seeds with a liquid dressing solution, including a housing delimiting a chamber for accommodating the seeds, a rotating system for mixing the seeds and the dressing solution, an air duct for feeding hot air into the chamber and a separating unit which is permeable to the hot air and separates the air duct from the chamber. According to this invention, the separating unit includes at least one perforated metal sheet that has an inner face facing towards the chamber, an outer face facing towards the air duct and a plurality of projections, wherein a projection rises obliquely in the direction of the outer face and forms an opening inlet, which is inclined to the metal sheet plane, on the outer face. This invention further relates to a method in which the device is used.

Abstract: A device for coating seeds with a liquid dressing solution, including a housing delimiting a chamber for accommodating the seeds, a rotating system for mixing the seeds and the dressing solution, an air duct for feeding hot air into the chamber and a separating unit which is permeable to the hot air and separates the air duct from the chamber. According to this invention, the separating unit includes at least one perforated metal sheet that has an inner face facing towards the chamber, an outer face facing towards the air duct and a plurality of projections, wherein a projection rises obliquely in the direction of the outer face and forms an opening inlet, which is inclined to the metal sheet plane, on the outer face. This invention further relates to a method in which the device is used.

Abstract: The invention relates to a nontoxic polysiloxane material and ripened polysiloxane material which has been formed using one or more different polysiloxane materials. According to the invention, such a ripened polysiloxane material can be spun, for example, into bioabsorbable and/or bioactive fibers and then be further processed into fibrous nonwoven webs.