Abstract: The present invention is in the field of delivering an active substance to the oral cavity and relates to mucoadhesive active composition and corresponding mucoadhesive dosage form, which can deliver an active substance within the oral cavity, especially an orodispersible tablet for delivering probiotic substance. The present invention also relates to a method of producing the said composition and a method of processing the composition into a mucoadhesive dosage form, especially an orodispersible tablet. The present invention moreover relates to a system and a method for testing the mucoadhesion of a dosage form.

Abstract: The present invention is in the field of delivering an active substance to the oral cavity and relates to mucoadhesive active composition and corresponding mucoadhesive dosage form, which can deliver an active substance within the oral cavity, especially an orodispersible tablet for delivering probiotic substance. The present invention also relates to a method of producing the said composition and a method of processing the composition into a mucoadhesive dosage form, especially an orodispersible tablet. The present invention moreover relates to a system and a method for testing the mucoadhesion of a dosage form.

Abstract: The present invention is in the field of delivering an active substance to the oral cavity and relates to mucoadhesive active composition and corresponding mucoadhesive dosage form, which can deliver an active substance within the oral cavity, especially an orodispersible tablet for delivering probiotic substance. The present invention also relates to a method of producing the said composition and a method of processing the composition into a mucoadhesive dosage form, especially an orodispersible tablet. The present invention moreover relates to a system and a method for testing the mucoadhesion of a dosage form.

Abstract: The present invention relates to a disposable absorbent article, e.g. a diaper, having a backsheet, an absorbent core and a topsheet, said absorbent article having a length L, said topsheet having an opening and primary elasticated areas and secondary elasticated areas, the latter being curved or angled, having an overall curvature with a radius of from 0.3 L to 3.2 L, wherein the average transverse distance between a primary elasticated area and a secondary elasticated area of a crotch side portion is preferably at least 15 mm.

Abstract: A disposable absorbent article with a backsheet and a first topsheet, is capable of being at least partially in contact with the wearer's skin when in use. The first topsheet being a fibrous three-dimensional web, having bonded regions where the fibers are bonded to another, and unbonded regions, where the fibers are unbonded to one another. The fibers extend from at least one unbonded region into at least two bonded regions, typically in the form of loops. The bonded regions form the support structure for the unbonded regions, and the surface area of the unbonded regions is at least 2 mm2. The topsheet has a thickness (caliper) of between 0.1 and 5 mm.

Abstract: The present invention relates to methods and products for improved production of the lantibiotic mersacidin. There is provided a method of producing a mersacidin variant which comprises introducing into a cell which is a ?MrsA host cell an expression vector encoding said variant, and recovering said variant from the cell culture. Preferred variants include the novel variants of Table 1, e.g. mersacidin F3W, said mersacidin F3W optionally having a further one or more variations, e.g. mersacidin F3W G8A. Also provided is a Bacillus cell which is a SigH deficient strain of Bacillus sp. HIL Y-85,54728 (NCIMB Accession Number NCIMB 41211); this cell may also be used in the production of mersacidin and its variants. Further aspects of the invention include a DNA cassette which comprises a nucleotide sequence encoding the mersacidin mrsA propeptide, and a method to transform a Bacillus HIL host cell with plasmid, which method includes the step of electroporation.

Abstract: The present invention relates to a disposable absorbent article, e.g. a diaper, having a backsheet, an absorbent core and a topsheet, said absorbent article having a length L, said topsheet having an opening and primary elasticated areas and secondary elasticated areas, the latter being curved or angled, having an overall curvature with a radius of from 0.3 L to 3.2L, wherein the average transverse distance between a primary elasticated area and a secondary elasticated area of a crotch side portion is preferably at least 15 mm.

Abstract: The present invention relates to a disposable absorbent article, e.g. a diaper, having a backsheet, an absorbent core and a topsheet, said absorbent article having a length L, said topsheet having an opening and primary elasticated areas and secondary elasticated areas, the latter being curved or angled, having an overall curvature with a radius of from 0.3 L to 3.2L, wherein the average transverse distance between a primary elasticated area and a secondary elasticated area of a crotch side portion is preferably at least 15 mm.

Abstract: The present invention relates to methods and products for improved production of the lantibiotic mersacidin. There is provided a method of producing a mersacidin variant which comprises introducing into a cell which is a ?MrsA host cell an expression vector encoding said variant, and recovering said variant from the cell culture. Preferred variants include the novel variants of Table 1, e.g. mersacidin F3W, said mersacidin F3W optionally having a further one or more variations, e.g. mersacidin F3W G8A. Also provided is a Bacillus cell which is a SigH deficient strain of Bacillus sp. HIL Y-85,54728 (NCIMB Accession Number NCIMB 41211); this cell may also be used in the production of mersacidin and its variants. Further aspects of the invention include a DNA cassette which comprises a nucleotide sequence encoding the mersacidin mrsA propeptide, and a method to transform a Bacillus HIL host cell with plasmid, which method includes the step of electroporation.

Abstract: The present invention relates to a disposable absorbent article, e.g. a diaper, having a backsheet, an absorbent core and a topsheet, said absorbent article having a length L, said topsheet having an opening and primary elasticated areas and secondary elasticated areas, the latter being curved or angled, having an overall curvature with a radius of from 0.3 L to 3.2L, wherein the average transverse distance between a primary elasticated area and a secondary elasticated area of a crotch side portion is preferably at least 15 mm.