Abstract: A compression system for applying compression to a limb of a user comprising a sleeve for substantially covering a portion of the limb of a user, the sleeve being provided with a plurality of fastening bands in series between upper and lower edges of the sleeve and a lateral side region being configured and arranged such that it is trimmable. The system further comprising a secondary closure element, said closure element releasably attachable to the lateral side region. The closure element further being provided with either a single elongate pair of flaps or a plurality of pairs of flaps, each including an exterior flap overlying an interior flap, where opposing inner surfaces of the interior and exterior flaps comprise mechanical fastening elements adapted to releasably engage the inner and outer surfaces, respectively, of at least the lateral side region of the sleeve.

Abstract: The present invention provides a pressure sensitive skin adhesive comprising: (a) a copolymer of one or more alkyl(meth)acrylates containing 4 to 12 carbon atoms in the alkyl group and one or more hydrophilic monomers; (b) a mixture of penetration enhancers comprising: (i) an alkyl ester of an aliphatic monocarboxylic acid containing 1 to 5 carbon atoms in the alkyl group (ii) an alkyl pyrrolidone and (iii) an alkane polyol (c) a therapeutically effective amount of diclofenac or a pharmaceutically acceptable salt thereof. Further provided is a transdermal drug delivery device containing the pressure sensitive skin adhesive.