Patents by Inventor Anjali J. Kalyani

Anjali J. Kalyani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lineage-Restricted Neuronal Precursors
    Publication number: 20130017179
    Abstract: A cell population has been identified and isolated that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This mammalian CNS neuron-restricted cell expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem cells (NEP cells) and spinal glial progenitors derived from embryonic day 10.5 spinal cord. Methods for isolating these cells and uses thereof are also disclosed.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 17, 2013
    Applicant: University of Utah Research Foundation
    Inventors: Mahendra S. Rao, Margot Mayer-Proschel, Anjali J. Kalyani
  • Lineage-Restricted Neuronal Precursors
    Publication number: 20090087851
    Abstract: A self-renewing restricted stem cell population has been identified in developing (embryonic day 13.5) spinal cords that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This neuronal-restricted precursor (NRP) expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem cells (NEP cells) and spinal glial progenitors derived from embryonic day 10.5 spinal cord. NRP cells self renew over multiple passages in the presence of fibroblast growth factor (FGF) and neurotrophin 3 (NT-3) and express a characteristic subset of neuronal epitopes. When cultured in the presence of RA and the absence of FGF, NRP cells differentiate into GABAergic, glutaminergic, and cholinergic immunoreactive neurons. NRP cells can also be generated from multipotent NEP cells cultured from embryonic day 10.5 neural tubes.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 2, 2009
    Inventors: Mahendra S. Rao, Margot Mayer-Proschel, Anjali J. Kalyani
  • Lineage-restricted neuronal precursors and methods of isolation
    Patent number: 6787353
    Abstract: A self-renewing restricted stem cell population has been identified in developing (embryonic day 13.5) spinal cords that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This neuronal-restricted precursor (NRP) expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem cells (NEP cells) and spinal glial progenitors derived from embryonic day 10.5 spinal cord. NRP cells self renew over multiple passages in the presence of fibroblast growth factor (FGF) and neurotrophin 3 (NT-3) and express a characteristic subset of neuronal epitopes. When cultured in the presence of RA and the absence of FGF, NRP cells differentiate into GABAergic, glutaminergic, and cholinergic immunoreactive neurons. NRP cells can also be generated from multipotent NEP cells cultured from embryonic day 10.5 neural tubes.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: September 7, 2004
    Assignee: University of Utah Research Foundation
    Inventors: Mahendra S. Rao, Margot Mayer-Proschel, Anjali J. Kalyani