Abstract: Variable temperature analytical instruments are provided that can include: a mobile component comprising a cold source; a substantially fixed analysis component; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a mobile analysis component; a substantially fixed component comprising a cold source; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a cold source in thermal communication with an analysis component; and at least one pressure barrier defining a plurality of discrete masses maintained at different temperatures between the cold source and the analysis component.

Abstract: Variable temperature analytical assemblies are provided and/or methods for changing temperatures of a mass are provided. Low thermal conductance components and/or assemblies are also provided. Methods for thermally isolating a mass from a support structure are also provided.

Abstract: Instrumental analysis systems are provided that can include: an analytical attachment axially aligned with a sample upon a sample stage; structure supporting both the attachment and the sample stage; and at least one band affixed to the analytical attachment and aligned symmetrically about the axis of the attachment. Methods for analyzing samples are provided. The methods can include: providing at least one band supported by a structure; firmly affixing an analytical attachment to the band, and axially aligning the attachment with a sample; and providing a temperature gradient between the band and the sample while maintaining axial alignment of the objective and the sample.

Abstract: Variable temperature analytical instruments are provided that can include: a mobile component comprising a cold source; a substantially fixed analysis component; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a mobile analysis component; a substantially fixed component comprising a cold source; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a cold source in thermal communication with an analysis component; and at least one pressure barrier defining a plurality of discrete masses maintained at different temperatures between the cold source and the analysis component.

Abstract: Variable temperature analytical instruments are provided that can include: a mobile component comprising a cold source; a substantially fixed analysis component; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a mobile analysis component; a substantially fixed component comprising a cold source; and an interface configured to couple the mobile component with the analysis component.

Abstract: Variable temperature analytical instrument heat exchanger components are provided that can include a conduit in thermal communication with at least one thermally discrete mass, the discrete mass being configured as a cold source to be coupled to a member to facilitate the transfer of thermal energy. Variable temperature analytical instrument components are also provided that can include: a first mass to be maintained at a first temperature; a first conduit in fluid communication with the first mass; and a second mass thermally connected to the first conduit, the second mass having a different temperature than the first mass. Methods for varying the temperature within variable temperature analytical instruments are also provided. The methods can include thermally coupling at least a portion of an exhaust fluid conduit with a first mass and using the first mass as a cold source.

Abstract: Variable temperature analytical instrument components are provided that can include: a conduit configured to extend between two chambers having different pressures; and a first mass about a section of the conduit, wherein the first mass is maintained at a first temperature. Variable temperature analytical instruments are provided that can include: a sample chamber configured to be operably coupled to a heat or cold source via one or more conduits; an interface component configured to engage the one or more conduits with the sample chamber, the interface comprising a conduit configured to extend between two chambers having different pressures; and a first mass about a section of the conduit, wherein the first mass is maintained at a first temperature. Methods for maintaining temperatures within a variable temperature analytical instrument are also provided.

Abstract: Instrumental analysis systems are provided that can include: an analytical attachment axially aligned with a sample upon a sample stage; structure supporting both the attachment and the sample stage; and at least one band affixed to the analytical attachment and aligned symmetrically about the axis of the attachment. Methods for analyzing samples are provided. The methods can include: providing at least one band supported by a structure; firmly affixing an analytical attachment to the band, and axially aligning the attachment with a sample; and providing a temperature gradient between the band and the sample while maintaining axial alignment of the objective and the sample.

Abstract: Variable temperature analytical instruments are provided that can include: at least one heat or cold source configured to generate a temperature; and discrete instrument portions individually thermally coupled to the at least one source. Methods for maintaining temperatures within variable temperature analytical instruments are also provided. The methods can include providing a plurality of thermal coupling between a plurality of discrete heat or cold sources to a plurality of discrete portions of the instrument.

Abstract: Variable temperature analytical instruments and components are provided that can include: first and second conduits both configured to receive fluid from a cryofluid source and provide same to an analysis component; and a housing about the conduits wherein the housing is configured to maintain a vacuum about the conduits. Methods for maintaining temperatures within variable temperature analytical instruments are also provided. The methods can include dynamically providing fluid from a cryofluid source through at least one of two conduits housed within a vacuum, to an analysis component.

Abstract: Cryogenic analytical systems are provided that can include: a cryogenic fluid source; one or more analysis components; at least one cryogenic thermal conduit operably coupled between the cryogenic fluid source and the one or more analysis components; and a pressure control component operably engaged with the cryofluid source. Methods for performing cryogenic analysis are provided. The methods can include adjusting the pressure of cryofluid within a cryogenic fluid source to configure one or more analysis components with a cryogenic temperature. Methods for configuring a cryogenic analytical system to perform cryogenic analysis are also provided. The methods can include: increasing the pressure within a cryogenic fluid source to rapidly cool one or more analysis components to a first temperature; and decreasing the pressure within the cryogenic fluid source to reduce the first temperature of the one or more analysis components.

Abstract: Cryogenic analysis systems are provided that can include: a cryogenic fluid source component; an analysis component; and a thermal connection assembly operably engaged with both the cryogenic fluid source component and the analysis component to provide disengagement or engagement of the cryogenic fluid source component to/from the analysis component while maintaining the cooling status of the cryogenic fluid source component. Methods for performing sample analysis under cryogenic conditions are provided, the methods comprising: providing an analysis component; providing a cryogenic fluid source component having cryogenic fluid in a cold state; operably engaging the analysis component and the cryogenic fluid source component; preparing a sample for analysis within the analysis component; and while maintaining the cryogenic fluid in the cold state, disengaging the cryogenic fluid source component from the analysis component.

Abstract: Instrumental analysis systems are provided that can include: an analytical attachment axially aligned with a sample upon a sample stage; structure supporting both the attachment and the sample stage; and at least one band affixed to the analytical attachment and aligned symmetrically about the axis of the attachment. Methods for analyzing samples are provided. The methods can include: providing at least one band supported by a structure; firmly affixing an analytical attachment to the band, and axially aligning the attachment with a sample; and providing a temperature gradient between the band and the sample while maintaining axial alignment of the objective and the sample.

Abstract: Cryocooler assemblies are provided that can include: a coldhead operatively engaged with a chamber configured to retain cryofluid; and a first thermally conductive mass thermally engaged with the cryofluid. Methods for providing one or more cold sources from a cryocooler are also provided. The methods can include operatively engaging at least the cryofluid of the cryocooler with one or more thermally conductive masses.

Abstract: Cryocooler assemblies are provided that can include: a first mass configured to generate mechanical responses; a second mass operably engaged with the first mass; and an assembly between the first and second mass, the assembly configured to allow movement of the first mass in relation to the second mass. Methods for isolating mechanical responses within a cryocooler assembly are provided. The methods can include: generating a mechanical response about a first mass within a cryocooler assembly; suspending the first mass in relation to a second mass of the assembly; and operatively engaging the second mass as a cold source for the cryocooler assembly.

Abstract: Variable temperature analytical instruments and components are provided that can include: first and second conduits both configured to receive fluid from a cryofluid source and provide same to an analysis component; and a housing about the conduits wherein the housing is configured to maintain a vacuum about the conduits. Methods for maintaining temperatures within variable temperature analytical instruments are also provided. The methods can include dynamically providing fluid from a cryofluid source through at least one of two conduits housed within a vacuum, to an analysis component.

Abstract: Variable temperature analytical instruments are provided that can include: at least one heat or cold source configured to generate a temperature; and discrete instrument portions individually thermally coupled to the at least one source. Methods for maintaining temperatures within variable temperature analytical instruments are also provided. The methods can include providing a plurality of thermal coupling between a plurality of discrete heat or cold sources to a plurality of discrete portions of the instrument.

Abstract: Variable temperature analytical instrument heat exchanger components are provided that can include a conduit in thermal communication with at least one thermally discrete mass, the discrete mass being configured as a cold source to be coupled to a member to facilitate the transfer of thermal energy. Variable temperature analytical instrument components are also provided that can include: a first mass to be maintained at a first temperature; a first conduit in fluid communication with the first mass; and a second mass thermally connected to the first conduit, the second mass having a different temperature than the first mass. Methods for varying the temperature within variable temperature analytical instruments are also provided. The methods can include thermally coupling at least a portion of an exhaust fluid conduit with a first mass and using the first mass as a cold source.

Abstract: Variable temperature analytical instrument components are provided that can include: a conduit configured to extend between two chambers having different pressures; and a first mass about a section of the conduit, wherein the first mass is maintained at a first temperature. Variable temperature analytical instruments are provided that can include: a sample chamber configured to be operably coupled to a heat or cold source via one or more conduits; an interface component configured to engage the one or more conduits with the sample chamber, the interface comprising a conduit configured to extend between two chambers having different pressures; and a first mass about a section of the conduit, wherein the first mass is maintained at a first temperature. Methods for maintaining temperatures within a variable temperature analytical instrument are also provided.

Abstract: Variable temperature analytical instruments are provided that can include: a mobile component comprising a cold source; a substantially fixed analysis component; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a mobile analysis component; a substantially fixed component comprising a cold source; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a cold source in thermal communication with an analysis component; and at least one pressure barrier defining a plurality of discrete masses maintained at different temperatures between the cold source and the analysis component.