Patents by Inventor Anka Veltcheva Evstatieva

Anka Veltcheva Evstatieva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-imino-methyl rifamycin SV
    Patent number: 6476036
    Abstract: Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamycin SV was synthesized. The compound shows high activity against Gram-positive and Gram-negative microorganims, Mycobacterium tuberculosis (including atypical and rifampicin resistant) and may be used in the medical practice. The sodium salt has formula (II). The process for preparation of the sodium salt consists of reacting equimolar quantities of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamycin SV and sodium ascorbate with addition of 30% methanol solution of sodium methylate, followed by filtration and removement of the solvent by distillation under reduced pressure. The compound can also be obtained from the sodium salt of 3-formil rifamycin SV, which is reacting with N1-amino-N4-cinnamypiperazin in medium of inert solvent at room temperature.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: November 5, 2002
    Inventors: Roumiana Gueorguieva Konstantinova, Kiril Asenov Ninov, Velitchka Ilieva Dimova, Anka Veltcheva Evstatieva