Patents by Inventor Anke Geick

Anke Geick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Nav1.8 GENE
    Publication number: 20090258934
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 15, 2009
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Dinah Sah, Maria Frank-Kamenetsky, Anke Geick, Philipp Hadwiger, Ingo Roehl, Pamela Tan, Hans-Peter Vornlocher
  • Compositions and methods for inhibiting expression of Nav1.8 gene
    Patent number: 7582745
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: September 1, 2009
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Dinah Sah, Maria Frank-Kamenetsky, Anke Geick, Philipp Hadwiger, Ingo Roehl, Pamela Tan, Hans-Peter Vornlocher
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE HAMP GENE
    Publication number: 20090209478
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the HAMP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HAMP gene expression and the expression of the HAMP gene using the pharmaceutical composition.
    Type: Application
    Filed: September 21, 2007
    Publication date: August 20, 2009
    Inventors: Tomoko Nakayama, Anke Geick, Pamela Tan, Herbert Y. Lin
  • COMPLEX FOR TRANSFERRING AN ANIONIC SUBSTANCE INTO A CELL
    Publication number: 20090176710
    Abstract: The present invention relates to compositions and methods for the delivery of an anionic substance using complexes, comprising the anionic substance and a peptide. These complexes are useful for delivering said anionic substance into a cell, particularly in therapeutic applications.
    Type: Application
    Filed: September 21, 2007
    Publication date: July 9, 2009
    Inventors: Phillipp Hadwiger, Anke Geick
  • RNAi Inhibition of Alpha-ENaC Expression
    Publication number: 20090156529
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Application
    Filed: June 16, 2008
    Publication date: June 18, 2009
    Inventors: Gino VAN HEEKE, Emma HICKMAN, Henry Luke DANAHAY, Pamela TAN, Anke GEICK, Hans-Peter VORNLOCHER
  • Compositions and methods for inhibiting expression of anti-apoptotic genes
    Patent number: 7473525
    Abstract: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising a complementary RNA strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially identical to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: January 6, 2009
    Assignee: Alnylam Europe AG
    Inventors: Roland Kreutzer, Stefan Limmer, Hans-Peter Vornlocher, Philipp Hadwiger, Anke Geick, Matthias Ocker, Christoph Herold, Detlef Schuppan
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE
    Publication number: 20070281899
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.
    Type: Application
    Filed: March 30, 2007
    Publication date: December 6, 2007
    Inventors: David Bumcrot, Pamela Tan, Hans-Peter Vornlocher, Anke Geick
  • RNAI INHIBITION OF INFLUENZA VIRUS REPLICATION
    Publication number: 20070197460
    Abstract: The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.
    Type: Application
    Filed: November 1, 2006
    Publication date: August 23, 2007
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Antonin Fougerolles, Tatiana Novobrantseva, Pamela Tan, Anke Geick, Rachel Meyers
  • Compositions and methods for inhibiting expression of Nav1.8 gene
    Publication number: 20070105806
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
    Type: Application
    Filed: November 3, 2006
    Publication date: May 10, 2007
    Inventors: Dinah Sah, Maria Frank-Kamenetsky, Anke Geick, Philipp Hadwiger, Ingo Roehl, Pamela Tan, Hans-Peter Vornlocher
  • RNAi modulation of the Rho-A gene and uses thereof
    Publication number: 20070042984
    Abstract: The invention relates to compositions and methods for modulating the expression of the RhoA gene, and more particularly to the downregulation of RhoA by chemically modified oligonucleotides.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 22, 2007
    Inventors: Juergen Soutschek, Pamela Tan, Anke Geick
  • RNAi modulation of the Rho-A gene in research models
    Publication number: 20070044161
    Abstract: The invention relates to compositions and methods for modulating the expression of the RhoA gene, and more particularly to the downregulation of RhoA by chemically modified oligonucleotides.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 22, 2007
    Inventors: Juergen Soutschek, Pamela Tan, Anke Geick, Stephane Budel
  • Compositions and methods for treating pancreatic cancer
    Publication number: 20040121348
    Abstract: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a K-ras oncogene, comprising a complementary RNA strand which is substantially identical to at least a part of a K-ras gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a K-ras oncogene using the pharmaceutical composition; and methods for inhibiting the expression of a K-ras oncogene in a cell.
    Type: Application
    Filed: March 7, 2003
    Publication date: June 24, 2004
    Applicant: Ribopharma AG
    Inventors: Roland Kreutzer, Stefan Limmer, Hans-Peter Vornlocher, Anke Geick, Matthias Ocker, Christoph Herold, Detlef Schuppan
  • Compositions and methods for inhibiting expression of anti-apoptotic genes
    Publication number: 20040001811
    Abstract: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising a complementary RNA strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially identical to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.
    Type: Application
    Filed: March 7, 2003
    Publication date: January 1, 2004
    Applicant: Ribopharma AG
    Inventors: Roland Kreutzer, Stefan Limmer, Hans-Peter Vornlocher, Philipp Hadwiger, Anke Geick, Matthias Ocker, Christoph Herold, Detlef Schuppan