Patents by Inventor Anke Rattenholl

Anke Rattenholl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for obtaining active pro-NGF and beta-NGF
    Patent number: 8501439
    Abstract: The invention relates to a method for producing biologically active ?-NGF from the proform proNGF. After expressing the proform of the ?-NGF in a prokaryotic host cell, the recombinant protein is isolated in the form of insoluble inactive aggregates (inclusion bodies). After the solubilization thereof in a strong denaturing agent and the subsequent conversion thereof into the natural conformation, which is determined by the disulfide bridges present in the natural ?-NGF, biologically active ?-NGF is obtained by subsequently splitting-off the prosequence.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: August 6, 2013
    Assignee: Scil Proteins GmbH
    Inventors: Anke Rattenholl, Adelbert Grossmann, Elisabeth Schwarz, Rainer Rudolph
  • Pharmaceutical preparations comprising human proNGF
    Patent number: 8318671
    Abstract: The invention relates to a method for producing biologically active ?-NGF from the proform proNGF. After expressing the proform of the ?-NGF in a prokaryotic host cell, the recombinant protein is isolated in the form of insoluble inactive aggregates (inclusion bodies). After the solubilization thereof in a strong denaturing agent and the subsequent conversion thereof into the natural conformation, which is determined by the disulfide bridges present in the natural ?-NGF, biologically active ?-NGF is obtained by subsequently splitting-off the prosequence.
    Type: Grant
    Filed: October 11, 1999
    Date of Patent: November 27, 2012
    Assignee: Scil Proteins GmbH
    Inventors: Anke Rattenholl, Adelbert Grossmann, Elisabeth Schwarz, Rainer Rudolph
  • METHOD FOR OBTAINING ACTIVE BETA-NGF
    Publication number: 20100203589
    Abstract: The invention relates to a method for producing biologically active ?-NGF from the proform proNGF. After expressing the proform of the ?-NGF in a prokaryotic host cell, the recombinant protein is isolated in the form of insoluble inactive aggregates (inclusion bodies). After the solubilization thereof in a strong denaturing agent and the subsequent conversion thereof into the natural conformation, which is determined by the disulfide bridges present in the natural ?-NGF, biologically active ?-NGF is obtained by subsequently splitting-off the prosequence.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Inventors: Anke Rattenholl, Adelbert Grossmann, Elisabeth Schwarz, Rainer Rudolph