Abstract: The present disclosure relates to polynucleotides encoding tethered interleukin-12 (IL-12) polypeptides comprising an IL-12 polypeptide and a membrane domain. The present disclosure also relates to vectors comprising the polynucleotides; host cells comprising the polynucleotides or vectors, polypeptides encoded by the polynucleotides; compositions comprising the polynucleotides, vectors, host cells, or polypeptides and a delivery agent; and uses thereof, including treatment of cancer.

Abstract: The present invention relates to the treatment of ocular diseases in a human subject In particular, the invention relates to an intracameral administration of a sustained release biodegradable intracameral implant.

Abstract: Example systems and methods provide input suggestions to a user to improve user experience on user devices. The input suggestions can be fill information from another app on device to the present app being used by user, information for performing a search (without the user having to copy-paste data or entering the data manually), responses to a message/notification received by the user, information/content/data to be shared between apps (without switching between apps), and emojis/GIFs that can be used by the user. The method includes analyzing one or more content of one or more screen displayed on device, generating at least one of a logical tree structure and a data mashup model of the one or more analyzed content for each screen, and providing a recommendation to a user. The recommendation can be a connected action or an input suggestion.

Abstract: A 2D/3D conversion interface component is configured to override the video processing capabilities associated with a conventional 2D display, re-formatting an incoming 3D video stream into a version compatible with a 2D display while preserving the 3D-type of presentation. An incoming “side-by-side” (SBS) 3D video stream is re-formatted into a “frame sequential” (serialized) format that appears as a conventional video stream input to the 2D display. The interface component also generates as an output a timing signal (synchronized with the converted frames) that is transmitted to a 3D viewing device (e.g., glasses). Therefore, as along as the 3D viewing device remains synchronized with the sequence of frames shown on the 2D display, the user will actually be viewing an interactive 3D video.

Abstract: The disclosure features methods for treating cancer, including solid tumors and disseminated cancers such as myeloid malignancies, using one or more mRNAs encoding an OX40L polypeptide, an IL-12 polypeptide, an IL-15 polypeptide, and combinations thereof.

Abstract: A needle-free connector assembly is provided that includes a main housing coupled to an indicator housing. A plunger is coupled to a bellows disposed in the main housing. An inlet port is disposed at an upstream end of the indicator housing and an outlet port is disposed at a downstream end of the main housing, with a valve disposed within the indicator housing and adjacent the inlet port. A switch member is slidingly disposed in the main housing, wherein the needle-free connector assembly provides both flow regulation and pressure indication when the switch member is in a downstream position and only pressure indication when the switch member is in an upstream position. Infusion sets and methods of operating a needle-free connector are also provided.

Abstract: A shared-nothing database system is provided in which parallelism and workload balancing are increased by assigning the rows of each table to “slices”, and storing multiple copies (“duplicas”) of each slice across the persistent storage of multiple nodes of the shared-nothing database system. When the data for a table is distributed among the nodes of a shared-nothing system in this manner, requests to read data from a particular row of the table may be handled by any node that stores a duplica of the slice to which the row is assigned. For each slice, a single duplica of the slice is designated as the “primary duplica”. All DML operations (e.g. inserts, deletes, updates, etc.) that target a particular row of the table are performed by the node that has the primary duplica of the slice to which the particular row is assigned. The changes made by the DML operations are then propagated from the primary duplica to the other duplicas (“secondary duplicas”) of the same slice.

Abstract: This disclosure involves stitching event data using identity mappings. An event analytics system generates and stores an event dataset including first event data for a first set of events associated with a user. The first event data includes timestamps and a device identifier. The system identifies second event data for a second event associated with the user. The second event data includes a timestamp, the device identifier, and a user identifier. The system appends the second event data to the event dataset. Based on the second event data, the system generates and stores an identity mapping that maps the device identifier to the user identifier. Asynchronously to generating and storing the event dataset, based on the identity mapping and a predetermined look-back window, the system updates the first event data to include the user identifier.

Abstract: A system is described that can include a first database, a simulator, and a second database. The first database can store data indicating operation of at least one module within a computing device of an autonomous vehicle. The simulator can receive the stored data from the first database. The simulator can generate, based on the received data, a simulation of the operation of the at least one module. The simulator can identify at least one portion of the simulation that indicates a deviation between the collected data and the simulated operation of the autonomous vehicle. The simulator can analyze the at least one portion of the simulation to generate metrics for the at least one portion of the simulation. The metrics can be used to avoid another deviation between the collected data and the simulated operation of the autonomous vehicle. The second database can store the metrics.

Abstract: Systems and methods forecast inbound telecommunications, and more particularly, analyze real-time and historical call center data, and apply a forecasting model to the data in order to predict inbound call volume. These systems and methods employ tools that manipulate call center data and generate visual representations of metrics pertaining to forecasting call center data via a dashboard.

Abstract: An example method includes: executing, by application analysis software executing in the virtualized computing system, process discovery agents on the VMs; receiving, at the application analysis software from the process discovery agents, process metadata describing processes executing on the VMs; generating signatures for the processes based on the process metadata; determining components of an application based on the signatures; determining components of an application based on the signatures; identifying, for a first component of the components, a component-specific metadata collector; executing, by the application analysis software, the component-specific metadata collector on a first VM of the VMs; and receiving, at the application analysis software from the component-specific metadata collector, custom metadata further describing a first process of the processes associated with the first component.

Abstract: A method includes acquiring a design layout of a standard cell, extracting feature information of one or more vias in the standard cell from the design layout, performing a circuit simulation to obtain first simulation outputs of the standard cell for input patterns by applying a first abnormal resistance value as a parasitic resistance value of a first via among the one or more vias, the first abnormal resistance value being different from a nominal parasitic resistance value of the first via, determining whether the first simulation outputs match corresponding expected outputs of the standard cell for the input patterns, and in response to one or more simulation outputs among the first simulation outputs not matching the corresponding expected outputs, recording one or more defect types for the first via having the first abnormal resistance value along with corresponding input patterns and corresponding simulation outputs.

Abstract: Techniques are described for selective extraction of color attributes from digital images that overcome the challenges experienced in conventional systems for color extraction. In an implementation, a user applies a region selector to a source image to select a portion of the source image for color attribute extraction. A graphics editing system identifies a selected region of the source image as well as visual objects of the source image included as part of the selected region. The graphics editing system iterates through the selected visual objects and extracts color attributes from the visual objects, such as color values, patterns, gradients, gradient stops, opacity, color area, and so forth. The graphics editing system then generates a color palette that includes the extracted color attributes, and the color palette is able to be utilized for various image editing tasks, such as digital image creation and transformation.

Abstract: A method of testing an integrated circuit on a test circuit board includes performing, by a processor, a simulation of a first heat distribution throughout an integrated circuit design, manufacturing the integrated circuit according to the integrated circuit design, and simultaneously performing a burn-in test of the integrated circuit and an automated test of the integrated circuit. The burn-in test has a minimum burn-in temperature of the integrated circuit and a burn-in heat distribution across the integrated circuit. The integrated circuit design corresponds to the integrated circuit. The integrated circuit is coupled to the test circuit board. The integrated circuit includes a set of circuit blocks and a first set of heaters.

Abstract: Memory on Package (MOP) apparatus with reverse CAMM (Compression Attached Memory Module) and compression mount technology (CMT) connector(s). The MOP includes a first (MOP) substrate to which one or more CPUs, SoC, and XPUs that is operatively coupled to one or more CAMMs with a CMT connector(s) disposed between an array of CMT contact pads on the CAMM substrate and an array of CMT contact pad on the substrate. The one or more CAMMs are include multiple memory chips or packages such as LP DDR chips or DDR (S)DRAM chips/packages mounted to an underside of the CAMM substrate via signal coupling means such as a ball grid array (BGA), where the CAMM orientation is inverted such that the memory chips/packages are disposed downward, resulting in a reduced Z-height of the MOP. A MOP may include two CAMMs with a respective CMT connector disposed between the CAMM substrates and the MOP substrate.

Abstract: A system connects a board to a substrate through an interposer board having compressible connectors through the interposer board. The connectors through the interposer board are compression-based connector pins that extends above and below the interposer board to make electrical contact between the board and the substrate. The system can include a plate to secure the board to the substrate and compress the compression-based connectors of the interposer board.

Abstract: In a method for deriving existential rules from knowledge graph data, a processor represents a knowledge graph using a geometric embedding. A processor transforms the geometric embedding to a syllogism logic representation using a geometric relationship. And a processor derives existential rules using standard transformation rules present in the syllogism logic representation.

Abstract: Methods of treating an eye for an ocular condition such as placing a composite depot comprising a xerogel with embedded degradable particles into an anterior chamber of an eye to deliver a therapeutic agent. The xerogel is a hydrogel after exposure to intraocular fluid and is degradable. The degradable particles comprise the therapeutic agent and hydrolytically degrade in the anterior chamber to provide a controlled release of the therapeutic agent into the eye. Materials and processes for making depots are provided as well as alternative methods of their use.

Abstract: In some implementations, a system may receive a submission associated with an innovation associated with an entity. The system may analyze, using a first machine learning model, the submission to identify a classification associated with the innovation. The system may analyze, using a second machine learning model in association with the classification, content of the submission to identify a characteristic of the innovation. The system may determine, using a third machine learning model and based on the characteristic, a ranking of the innovation relative to individual innovations in the subset of innovations. The system may determine, using a fourth machine learning model, an impact score associated with the innovation. The system may perform, based on the impact score satisfying a threshold, an action associated with a project involving the innovation.

Abstract: Various embodiments include a parallel processing computer system that enables parallel instances of a program to synchronize at disparate addresses in memory. When the parallel program instances need to exchange data, the program instances synchronize based on a mask that identifies the program instances that are synchronizing. As each program instance reaches the point of synchronization, the program instance blocks and waits for all other program instances to reach the point of synchronization. When all program instances have reached the point of synchronization, at least one program instance executes a synchronous operation to exchange data. The program instances then continue execution at respective and disparate return addresses.