Patents by Inventor Ankur Garg
Ankur Garg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8229561Abstract: Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response. If capture is not detected, the system may deliver additional atrial pacing pulses to reduce atrial retrograde conduction. A backup pace may be delivered to prevent the atrial retrograde conduction if an atrial evoked response is not detected during a cardiac cycle. Alternatively, retrograde management may involve delaying a next scheduled pace may be until expiration of an atrial effective refractory period.Type: GrantFiled: December 15, 2004Date of Patent: July 24, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Geng Zhang, Ankur Garg
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Patent number: 8190256Abstract: Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis, for example.Type: GrantFiled: July 23, 2009Date of Patent: May 29, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Jesse W. Hartley, Kent Lee, Quan Ni, Michael A. Querimit, Kenneth L. Baker, Ankur Garg, Kenneth L. Tobacman, Corey J. Miklos
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Patent number: 7957803Abstract: Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.Type: GrantFiled: August 13, 2009Date of Patent: June 7, 2011Assignee: Cardiac Pacemakers, Inc.Inventors: Geng Zhang, Ankur Garg, Douglas R. Daum
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Publication number: 20110092585Abstract: The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscosa along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.Type: ApplicationFiled: September 1, 2010Publication date: April 21, 2011Applicants: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Anirban Pal, Sunil Kumar Chattopadhyay, Mahendra Pandurang Darokar, Rajendra Prasad Patel, Anil Kumar Gupta, Arvind Singh Negi, Tanpreet Kaur, Sudeep Tandon, Atul Prakash Kahol, Ankur Garg
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Patent number: 7801610Abstract: Methods and systems for classifying cardiac responses to pacing stimulation and managing retrograde conduction and pacemaker mediated tachyarrhythmia are described. An atrial pacing pulse and a ventricular pacing pulse are delivered during a paced cardiac cycle. A post ventricular atrial refractory period (PVARP) is timed following the ventricular pacing pulse. The system determines if the atrial pacing pulse captures the atrium. An atrial depolarization occurring after the paced cardiac cycle is sensed. Retrograde management is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization occurred during the PVARP. Pacemaker mediated tachyarrhythmia (PMT) is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization did not occur during the PVARP.Type: GrantFiled: November 17, 2006Date of Patent: September 21, 2010Assignee: Cardiac Pacemakers, Inc.Inventors: Derek D. Bohn, Ankur Garg, Eric K. Enrooth
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Patent number: 7767798Abstract: The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.Type: GrantFiled: March 2, 2006Date of Patent: August 3, 2010Assignee: Council of Scientific & Industrial ResearchInventors: Suman Preet Singh Khanuja, Santosh Kumar Srivastava, Ankur Garg, Merajuddin Khan, Mahendra Pandurang Dardokar, Anirban Pal
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Publication number: 20100114226Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.Type: ApplicationFiled: January 13, 2010Publication date: May 6, 2010Inventors: Imad Libbus, Qingsheng Zhu, Scott Vanderlinde, Andrew P. Kramer, Ankur Garg, Kristofer J. James
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Patent number: 7660628Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.Type: GrantFiled: March 23, 2005Date of Patent: February 9, 2010Assignee: Cardiac Pacemakers, Inc.Inventors: Imad Libbus, Qingsheng Zhu, Scott Vanderlinde, Andrew P. Kramer, Ankur Garg, Kristofer J. James
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Publication number: 20090306737Abstract: Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.Type: ApplicationFiled: August 13, 2009Publication date: December 10, 2009Inventors: Geng Zhang, Ankur Garg, Douglas R. Daum
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Publication number: 20090281589Abstract: Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis, for example.Type: ApplicationFiled: July 23, 2009Publication date: November 12, 2009Inventors: Jesse W. Hartley, Kent Lee, Quan Ni, Michael A. Querimit, Kenneth L. Baker, Ankur Garg, Kenneth L. Tobacman, Corey J. Miklos
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Patent number: 7587240Abstract: Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient'heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.Type: GrantFiled: December 15, 2004Date of Patent: September 8, 2009Assignee: Cardiac Pacemakers, Inc.Inventors: Geng Zhang, Ankur Garg, Douglas R. Daum
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Patent number: 7579491Abstract: The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.Type: GrantFiled: October 10, 2006Date of Patent: August 25, 2009Assignee: Council of Scientific and Industrial ResearchInventors: Sunil Kumar Chattopadhyay, Sachin Srivastava, Arvind Singh Negi, Ranganathan Santha Kumar Tirupadiripuliyur, Ankur Garg, Suman Preet Singh Khanuja
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Patent number: 7577479Abstract: Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis.Type: GrantFiled: March 17, 2005Date of Patent: August 18, 2009Assignee: Cardiac Pacemakers, Inc.Inventors: Jesse W. Hartley, Kent Lee, Quan Ni, Michael A. Querimit, Kenneth L. Baker, Ankur Garg, Kenneth I. Tobacman, Corey J. Miklos
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Publication number: 20090105777Abstract: A remote external interface for an implantable cardiac function management device is configured to be communicatively coupled to the implantable cardiac function management device via a network to a local external interface and via telemetry between the local external interface and the implantable cardiac function management device. The remote external interface includes a communication circuit and a processor circuit. The communication circuit is configured to communicate with the implantable cardiac function management device. The processor circuit is configured to perform an analysis of physiologic data received from the implantable cardiac function management device in response to operation of the implantable cardiac function management device using a plurality of therapy control parameter sets. The processor circuit can be further configured to select a particular therapy control parameter set using the analysis.Type: ApplicationFiled: October 10, 2008Publication date: April 23, 2009Inventors: Yanting Dong, Xuan Wei, Ankur Garg, Quan Ni
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Patent number: 7403817Abstract: A cardiac pacemaker programmed to pace in a demand mode with hysteresis is further programmed to recognize and correct a pacemaker mediated bradycardia. Such a pacemaker mediated bradycardia is the result of an idioventricular rhythm that occurs while hysteresis is operative and which inhibits the pacemaker from further pacing.Type: GrantFiled: February 14, 2003Date of Patent: July 22, 2008Assignee: Cardiac Pacemakers, Inc.Inventors: David L. Perschbacher, Ankur Garg, James O. Gilkerson
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Publication number: 20080119902Abstract: Methods and systems for classifying cardiac responses to pacing stimulation and managing retrograde conduction and pacemaker mediated tachyarrhythmia are described. An atrial pacing pulse and a ventricular pacing pulse are delivered during a paced cardiac cycle. A post ventricular atrial refractory period (PVARP) is timed following the ventricular pacing pulse. The system determines if the atrial pacing pulse captures the atrium. An atrial depolarization occurring after the paced cardiac cycle is sensed. Retrograde management is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization occurred during the PVARP. Pacemaker mediated tachyarrhythmia (PMT) is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization did not occur during the PVARP.Type: ApplicationFiled: November 17, 2006Publication date: May 22, 2008Inventors: Derek D. Bohn, Ankur Garg, Eric K. Enrooth
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Publication number: 20080119905Abstract: Methods and systems for performing capture threshold tests are described. During an initialization procedure a capture detection interval and capture detection threshold are determined based on peak values of cardiac signals sensed following the supracapture threshold initialization pulses. Following initialization, a plurality of pacing pulses to the atrium are delivered and the peak values of the cardiac signals sensed following each of the plurality of pacing pulses are determined. The peak values are compared to the pacing artifact threshold and the capture detection threshold. A timing of each of the peak values is compared to the capture detection interval. For each pacing pulse, discrimination between a captured response, a noncaptured response, and a fusion response is based on the peak value and timing comparisons.Type: ApplicationFiled: November 17, 2006Publication date: May 22, 2008Inventors: Derek D. Bohn, Ankur Garg, Eric K. Enrooth
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Publication number: 20080039641Abstract: The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.Type: ApplicationFiled: October 10, 2006Publication date: February 14, 2008Applicant: Council of Scientific and Industrial ResearchInventors: Sunil Chattopadhyay, Sachin Srivastava, Arvind Negi, Ranganathan Tirupadiripuliyur, Ankur Garg, Suman Khanuja
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Publication number: 20070258989Abstract: The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.Type: ApplicationFiled: December 5, 2006Publication date: November 8, 2007Applicants: Council of Scientific and Industrial Research, Department of BiotechnologyInventors: Suman Khanuja, Anirban Pal, Sunil Chattopadhyay, Mahendra Darokar, Rajendra Patel, Anil Gupta, Arvind Negi, Tanpreet Kaur, Sudeep Tandon, Atul Kahol, Ankur Garg
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Publication number: 20070123474Abstract: The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.Type: ApplicationFiled: March 2, 2006Publication date: May 31, 2007Inventors: Suman Khanuja, Santosh Srivastava, Ankur Garg, Merajuddin Khan, Mahendra Dardokar, Anirban Pal